Clayton A. Wiley, MD, PhD
PERF Professor of Pathology

Dr. Wiley
Dr. Wiley is Director of the Division of Neuropathology. In addition to clinical sign out, Dr. Wiley directs the Neuropathology fellowship program and runs an NIH funded research program studying neuroinflammation and viral encephalitis in particular.

Office Location:
S701.4 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
Contact Information:
Office Telephone: 412-624-0764
Fax: 412-624-5610
Email Address: wileyca@upmc.edu

Education

  • MD - University of California, San Diego, 1981
  • PhD - University of California, San Diego, 1981

Certification

Board certified in AP and NP 1985

Specialties

Neuropathology

Awards and Honors

Fellow American Association for Advancement of Science

Clinical Expertise

Dr. Wiley is board certified in Neuropathology with specific expertise in infectious disease.

Research Interests

Dr. Wiley's research concentrates on the pathogenesis of neurodegenerative disorders and in particular on viral and trauma induced nervous system diseases. Viruses damage the nervous system either by direct infection of neural cells or by secondary effects of an immune response. In recent years his studies have focused on central nervous system lentiviral, arboviral, enteroviral and influenzal infections and have pioneered the use of molecular and imaging techniques to quantitatively assess viral burden and neuroinflammation. This same technology is now being applied to quantify neurological damage and the immune response to brain trauma. In addition to human studies of AIDS and Alzheimer’s dementia, Dr. Wiley’s lab uses H5N1 and H1N1 infected mice, ferrets and non-human primates to model viral encephalitis. Using MRI, PET and laser confocal microscopy they are investigating the evolution of the innate immune response, extracellular matrix degradation and macrophage trafficking in mediating neurological disease. Recent studies have focused on the role of immunization to modulate infectious (West Nile Virus, Influenza, Rift Valley Fever Virus, Human Parechovirus) and non-infectious (Alzheimer’s) neurological disease. Through extensive collaborations with neuroscientists throughout the Pittsburgh community, Dr. Wiley leads a team studying the interactions between aging and lentiviral infection on physiology and pathology of the nervous system.

NIH Research

View Dr. Wiley's NIH RePORT on nih.gov

Selected Publications

View Dr. Wiley's publications on PubMed

  • Wiley CA, Bonneh-Barkay D, Dixon CE, Lesniak A, Wang G, Bissel SJ and Kochanek PM: Role for mammalian chitinase 3-like protein 1 in traumatic brain injury. Neuropathology (2015) 35:95-106. PMID: 25377763.
  • Mardekian SK, Fortuna D, Nix A, Bhatti T, Wiley CA, Flanders A, Urtecho, J, Sloane, J, Ahmad, J and Curtis, M. T. Severe Human Parechovirus Type 3 Myocarditis and Encephalitis in an Adolescent with Hypogammaglobulinemia. International Journal of Infectious Diseases 2015. doi: 10.1016/j.ijid.2015.05.008. PMID: 25975649.
  • Bissel SJ, Auer R, Chiang C-H, Kofler J, Murdoch GH, Nix WA, Painter M, Richer M, Startelet H and Wiley CA: Human Parechovirus 3 Meningitis and Fatal Leukoencephalopathy. J Neuropathology and Experimental Neurology (2015) PMID: 26115191.
  • CH Chiang, CT Chu & CA Wiley. (2015) A 67 year old man with multiple sclerosis and new onset cerebellar lesions. (progressive multifocal leucoencephalopathy with superimposed immune reconstitution inflammatory syndrome). Electronically published March 15, 2015. Brain Pathol, 25:507-508, PMID: 26095593.
  • Bissel SJ, Kofler J, Nyaundi J, Mickey-Corb M, Wisniewski SR, Wiley CA. Cerebral Spinal Fluid Biomarkers of Primate Lentiviral Encephalitis. J Neuroimmune Pharmacol (2016) 11(2):332-347. PMCID: in process
  • Wiley, C. A, Bissel, S. J., Lesniak, A., Dixon, C. E., Franks, J., Stolz, D. B., Sun, M., Wang, G., Switzer III, R. C., Kochanek, P. M. and Murdoch, G. H. Ultrastructure of diaschisis lesions following traumatic brain injury. J Neurotrauma 2016 In Press. PMID: 26914973.