Steven D. Shapiro, MD
Senior Vice President and Chief Medical and Scientific Officer, UPMC
Professor of Medicine
Dr. Shapiro is a Professor in the Department of Medicine at the University of Pittsburgh and a member of the Cellular and Molecular Pathology Graduate Training Program.
Office of the CMSO, UPMC
U.S. Steel Tower
600 Grant Street, Suite 6250
Pittsburgh, PA 15219
Office Telephone: 412-605-3995
Lab Location: BST W1258
Lab Telephone: 412-624-2075
- BA - University of Chicago, 1978
- MD - University of Chicago, Pritzker School of Medicine, 1983
Research InterestsDr. Shapiro's scientific career has focused on understanding the biological functions of matrix degrading proteinases in general and COPD in particular.
His laboratory developed a model of cigarette smoke-induced emphysema in mice and generated mice deficient in candidate proteinases by gene targeting to directly determine the contribution of individual proteinases to COPD. Applying these mutant mice to this model, he determined that MMP-12 and to a lesser degree neutrophil elastase are required for the development of emphysema as well as macrophage recruitment in COPD. This finding has changed the paradigm regarding COPD pathogenesis.
His laboratory has also generated "knockout" mice to determine other biological and pathological functions of proteinases. For example, they found that neutrophil elastase plays an important role in fighting Gram negative bacterial infections by degrading outer wall Omp proteins. MMP-12 also appears to have unique host defense properties, being the only directly antimicrobial MMP and the one MMP that limits, rather than promotes, tumor progression.
Current directions include continuing to determine the biological and pathological function of proteinases. With respect to COPD the goals are to understand the process of repair and to utilize stem cells and bioengineered extracellular matrix to improve lung function. Use of a multidisciplinary approach to COPD is a major focus that we hope will lead to disease modifying therapy.
Dr. Shapiro has maintained his clinical interests while pursuing his research and still is involved in clinical care and teaching.
Awards and Honors
- 1990 - 1993 - Edward Livingston Trudeau Scholar Award, American Lung Association
- 1994 - 1997 - Career Investigator Award, American Lung Association
- 1997 - Present - American Society of Clinical Investigation - Speaker, 1st Annual New Member Plenary Session
- 2002 - Present - American Association of Physicians (Speaker, Plenary Session)
- 2003 - 2006 - Inter-Urban Club Member
- 2004 - American Thoracic Society Scientific Achievement Award
- 2004 - Alton Ochsner Award Relating Tobacco and Health
- 2006 - Present - Inter-Urban Club Emeritus Member
Selected PublicationsView Dr. Shapiro's publications on PubMed
Minematsu N, Blumental-Perry A, Shapiro SD. Cigarette Smoke Inhibits Engulfment of Apoptotic Cells by Macrophages through Inhibition of Actin Rearrangement. American journal of respiratory cell and molecular biology. 2011 Apr; 44 (4):474-82. PMID: 20525804.
Foreman MG, Kong X, DeMeo DL, Pillai SG, Hersh CP, Bakke P, Gulsvik A, Lomas DA, Litonjua AA, Shapiro SD, Tal-Singer R, Silverman EK. Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease. American journal of respiratory cell and molecular biology. 2011 Mar; 44 (3):316-22. PPMID: 20448057.
Yoshida T, Mett I, Bhunia AK, Bowman J, Perez M, Zhang L, Gandjeva A, Zhen L, Chukwueke U, Mao T, Richter A, Brown E, Ashush H, Notkin N, Gelfand A, Thimmulappa RK, Rangasamy T, Sussan T, Cosgrove G, Mouded M, Shapiro SD, Petrache I, Biswal S, Feinstein E, Tuder RM. Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nature medicine. 2010 Jul; 16 (7):767-73. PMID: 20473305.
Leme AS, Berndt A, Williams LK, Tsaih SW, Szatkiewicz JP, Verdugo R, Paigen B, Shapiro SD. A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci. Molecular genetics and genomics : MGG. 2010 Apr; 283 (4):317-26. PMCID: PMC2885868. PMID: 20143096.
Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, Stolz DB, Land SR, Marconcini LA, Kliment CR, Jenkins KM, Beaulieu KA, Mouded M, Frank SJ, Wong KK, Shapiro SD. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nature medicine. 2010 Feb; 16 (2):219-23. PMCID: PMC2821801. PMID: 20081861.
Cackowski FC, Anderson JL, Patrene KD, Choksi RJ, Shapiro SD, Windle JJ, Blair HC, Roodman GD. Osteoclasts are important for bone angiogenesis. Blood. 2010 Jan 7; 115 (1):140-9. PMID: 19887675.
Khatwa UA, Kleibrink BE, Shapiro SD, Subramaniam M. MMP-8 promotes polymorphonuclear cell migration through collagen barriers in obliterative bronchiolitis. Journal of leukocyte biology. 2010 Jan; 87 (1):69-77. PMCID: PMC2801621. PMID: 19801498.