Miguel Reyes-Múgica, MD
Marjory K. Harmer Endowed Chair in Pediatric Pathology
Dr. Reyes-Múgica is the Chief of the Division of Pediatric Pathology.
Department of Pathology
Children's Hospital of Pittsburgh
One Children's Hospital Drive
4401 Penn Avenue
Pittsburgh PA 15224
Office Telephone: 412-692-5650
Michelle Vinski - Administrative Coordinator
- MD - National Autonomous University of Mexico (UNAM), México City, México, 1982
In the clinical-pathological area, we continue working with Dr. Luis De La Torre, who I helped to bring from México to launch and direct the brand new Colorectal Center at Children's Hospital of Pittsburgh. Dr. De La Torre is a recognized authority in the field of Hirschsprung disease from the surgical viewpoint, and we are working with him to improve diagnosis and understanding on this common pediatric condition. Our efforts are directed towards a more uniform and reproducible diagnostic approach.
My main interests include the study of biological features of a group of disorders knows as "neurocristopathies". In particular, the biology of congenital nevi, and the improvement of diagnostic approaches to the complex neural crest malformation called Hirschsprung disease.
In our laboratory we concentrate in pediatric melanocytic proliferations, in particular Giant Congenital Melanocytic Nevi and a relatively rare associated entity called neurocutaneous melanocytosis (NCM). Patients with this condition are born with large pigmented nevi and later develop meningeal/brain melanocytic proliferations. Little is known about the biology of these lesions and how they compare with other, more conventional melanocytic proliferations, such as malignant melanoma. Our past efforts have centered on studying genes associated with familial melanoma, which apparently are not involved in this condition. Now we are working in collaboration with a number of clinical and surgical researchers, and with the support group Nevus Outreach, Inc., we have established a tissue repository for samples samples derived from patients afflicted with these conditions. In addition, a recent gift from a generous family was received to support our tissue repository, which has now been renamed as "The Gavin Bailey Tissue Repository for Neural Crest Disorders". At the time of this report, we have accumulated samples from approximately 130 patients afflicted with Giant Melanocytic Nevi, including 21 patients with NCM. In collaboration with Dr. Marina Nikiforova, from the Molecular Pathology Laboratory, we have interrogated our samples in regard to their NRAS, BRAF (and other target genes) status. Our results showing BRAF mutations in NCM patients, as well as a particular phenotype associated with BRAF mutations in Giant Nevi, were presented at the joint SPP/PPS meeting in Birmingham, UK, in September 2014, and published in Januray of 2015. An Editorial comment on these studies appeared in Dermatology Times. This advanced genetic and morphological characterization of NCM lesions, will improve our understanding of their biology, allowing us to discover potential targets for therapy. We have also found that not only mutations, but amplification of mutated NRAS appears to play a significant role in melanomagenesis in the context of NCM. This observation has been accepted for publication in Melanoma Research. We have ongoing collaborations with Ruth Halaban from Yale, and are working with Dr. Harper Price from Phoenix Children's Hospital to accrue more tissues from her patients. Dr. Stewart Cramer, an expert in the field of nevogenesis, and are working with a group of pediatric and adult nevi, establishing comparisons in terms of their immunophenotype and maturation patterns.
An additional field of interest is the pathology of pediatric testicular lesions. We continue working with the groups of Pediatric Endocrinology and Pediatric Urological Surgery in order to analyze patients with Disorders of Sex Development, trying to expand their characterization. This work is also in collaboration with Dr. Katja Gwin, from Southwestern University. In this context, I have recently published 20 out of 25 chapters (peer-reviewed articles) for a supplement dedicated to Pediatric Testicular Pathology, sponsored by the Society for Pediatric Pathology, the bound volume will be published in 2016, but each chapter/article will be finished (as of this writing only 5 remain in review) by the end of 2015.
Lastly, I continue collaborative work with the ELGAN (Extremely Low Gestational Age Neonate) group, and also work on other areas of General Pediatric Pathology, specifically, tumor pathology.
- Pediatric and Developmental Pathology, Editor-in-Chief
- Society for Pediatric Pathology
- United States and Canadian Academy of Pathology
- Asociación Mexicana de Patólogos
- Sociedad Latinoamericana de Patologia Pediatrica (SLAPPE)
- Sociedad Latinoamericana de Patologia (SLAP)
- College of American Pathologists
- Latin American Pathology Foundation, Ex-President
Selected PublicationsView Dr. Reyes-Múgica's publications on PubMed
- Andrews R, Baumhardt H, Martin B, Belachew D, Reyes-Múgica M. Oral Manifestations of Hyperparathyroidism Secondary to Familial Hypophosphatemic Rickets. Pediatr Dentistry 2014;36(5):422-424.
- Picarsic J, Reyes-Múgica M. Phenotype And Immunophenotype Of The Most Common Pediatric Tumors. Appl Immunohistochem Mol Morphol Appl Immunohistochem Mol Morphol. 2015 May-Jun;23(5):313-26. doi: 10.1097/PAI.0000000000000068.
- Salgado CM, Basu D, Nikiforova M, Bauer BS, Johnson D, Rundell V, Grunwaldt LJ, Reyes-Múgica M. BRAF Mutations Are Also Associated With Neurocutaneous Melanocytosis and Large/Giant Congenital Melanocytic Nevi. Pediatr Dev Pathol. 20 2015 Jan-Feb;18(1):1-9.
- Salgado CM, Basu D, Nikiforova M, Hamilton RL, Gehris R, Jakacki R, Panigrahy A, Yatsenko S, Reyes-Múgica M. Amplification of Mutated NRAS Leading to Congenital melanoma. Melanoma Research (in press).
- Dangle, P, Correa A, Tennyson L, Gayed B, Reyes-Múgica M, Ost M. Testicular Rhabdomyosarcoma. Urol Clin North Am (in press).
- Feingold B, Salgado CM, Reyes-Múgica M, Drant S, Miller SA, Kellman P, Schelbert EB, Wong TC. Myocardial Fibrosis Quantified by Cardiovascular Magnetic Resonance is Associated with Histology and Graft Function after Pediatric Heart Transplantation (in revision).
- Basu D, Salgado CM, Bauer BS, Johnson D, Rundell V, Nikiforova M, Khakoo Y, Grunwaldt LJ, Panigrahy A, Reyes-Múgica M. Nevospheres From Neurocutaneous Melanocytosis Cells Show Reduced Viability When Treated With Specific Inhibitors Of NRAS Signaling Pathway. J Neurooncology (in revision).
- Zambrano EV, DeStefano D, Reyes-Múgica M. Pediatric Germ Cell Tumors. Pathology and Biology of Cell Tumors. Nogales F, Jimémez R. Springer (submitted).
- Chou P, Gattuso P, Reddy VB, Reyes-Múgica M, Editors. Diagnostic Pediatric Cytopathology and Histopathologic Correlation. Cambridge University Press. Scheduled for January 2015. In press.