Zoltan Nagy Oltvai, MD
Associate Professor of Pathology

Dr. Oltvai is a staff pathologist in the Division of Clinical Microbiology. He is also a faculty member of the Interdisciplinary Biomedical Science Graduate Program, the Medical Scientist Training Program, the Cellular and Molecular Pathology Graduate Training Program, and the Joint CMU-Pitt PhD Program in Computational Biology.

Office Location:
Rm. S701 Scaife Hall
3550 Terrace St.
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-383-7408
Lab Telephone: 412-648-8519
Fax: 412-383-9594
Email: oltvai@pitt.edu


  • MD - Semmelweiss Medical University, Budapest

Clinical Expertise

Molecular Diagnostics (hereditary diseases, infectious diseases, hematologic malignancies)

Research Interests

Dr. Oltvai's research interest is in the area of systems biology of cell metabolism, including the metabolism of prokaryotic and mammalian cells, including tumor cells.


Clinical Pathology, 1998 (The American Board of Pathology)


Molecular Diagnostics, Pathology Informatics

Selected Publications

View Dr. Oltvai's publications on PubMed

Shen, Y., Liu, J., Estiu, G., Isin, B., Ahn, Y-Y., Lee, D-S., Barabasi, A.-L., Kapatral, V., Wiest, O., and Oltvai, Z.N., Blueprint for antimicrobial hit discovery targeting metabolic networks. Proc. Natl. Acad. Sci. U.S.A. 107, 1082-87 (2010)

Vazquez, A., Liu, J., Zhou, Y., and Oltvai, Z.N. Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited. BMC Systems Biol., 4, 58 (2010)

Vazquez, A., and Oltvai, Z.N. Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology. PLoS ONE 6 (e19538), 1-9 (2011)

Vazquez, A., Markert, E.K., and Oltvai, Z.N. Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. PLoS ONE, 6 (e25881), 1-10 (2011)

Isin, B., Estiu, G., Wiest, O., and Oltvai, Z.N., (2012) Identifying ligand binding conformations of the β2-adrenergic receptor by using its agonists as computational probes. PLoS ONE, 7 (e50186), 1-12

Tedeschi, P.M., Markert, E.K., Gounder, M., Lin, H., Dvorzhinski, D., Dolfi, S.C., Chan, L.L., Qiu, J., DiPaola, R.S., Hirshfield, K.M., Boros, L.G., Bertino, J.R., Oltvai, Z.N. and Vazquez, A. (2013) Contribution of serine, folate and glycine metabolism to the ATP, NADPH, and purine requirements of cancer cells. Cell Death Dis., 4, e877

Dolfi, S.C., Chan, L.L., Qiu, J., Tedeschi, P.M., Bertino, J.R., Hirshfield K.M., Oltvai, Z.N. and Vazquez, A., (2013) The metabolic demands of cancer cells are coupled to their size and protein synthesis rates. Cancer & Metab.,1:20

Zhou, Y., Vazquez, A., Wise, A., Warita, T., Warita, K., Bar-Joseph, Z., and Oltvai, Z.N. (2013) Carbon catabolite repression correlates with the maintenance of near invariant molecular crowding and optimal biomass production in proliferating E. coli cells. BMC Systems Biol. 7:138