Dr. Chang is a member of the University of Pittsburgh Cancer Institute at the University of Pittsburgh. Office Location: Hillman Cancer Center Research Pavilion, Suite 1.8 5117 Centre Avenue Pittsburgh, PA 15213-1863 Contact Information: Office Phone: (412) 623-7721 Fax: (412) 623-7715 Email Address: yc70@pitt.edu Research Interests: We are investigating the epidemiology and biological properties of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8), a new human DNA tumor virus discovered in our laboratory. KSHV causes Kaposi's sarcoma, the most common AIDS-associated malignancy as well as two lymphoproliferative disorders: a form of nonHodgkin's B-cell primary effusion lymphoma and a subtype of Castleman's disease (MCD). Through extensive molecular piracy, the KSHV genome contains a wide array of genes which affect host cell proliferation pathways, apoptosis, cell cycle regulation and immune modulation. Tools used in our laboratory include molecular biology, protein biochemistry, and virologic methods. Selected Publications: Chatterjee M, Osborne J, Bestetti G, Chang Y, Moore PS. Viral Interleukin-6 Induced Cell Proliferation Results from Immune Evasion of Interferon Activity. Science 2002; 298:1432-1435. Moore PS, Chang Y. Kaposi's Sarcoma-Associated Herpesvirus Immunoevasion and Tumorgensis: Two Sides of the Same Coin? Ann Rev Microbiol. 2003;57:609-39. Laney AS, De Marco T, Peters JS, Malloy M, Teehankee C, Moore PS, Chang Y. Kaposi sarcoma-associated herpesvirus and primary and secondary pulmonary hypertension. Chest. 2005 ;127(3):762-7. Taylor JL, Bennett HN, Snyder BA, Moore PS, and Chang Y. Transcriptional analysis of the latent and inducible KSHV transcripts in the K4-K7 region. J Virol 2005; 79(24):15099-106. Corte-Real S, Collins C, Aires da Silva F, Simas JP, Barbas C, Chang Y, Moore P, Goncalves J. Intrabodies targeting the Kaposi's sarcoma-associated herpesvirus latency antigen inhibit viral persistence Blood 2005; 106(12):3797-802. Laney AS, Peters J., Manzi S., Kingsley L., Chang Y., Moore P.S. Diagnosis of Kaposi's sarcoma-associated herpesvirus infection (KSHV/HHV8) using a multiantigen detection algorithm J Clin Micro 2006 Oct;44(10):3734-41. Chang Y, Jaffe H, Moore PS. KSHV serology. Letter. N Engl J Med. 2007 Jan 4;356(1):88