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Research Interests:
Dr. Bell's research interest lie in understanding the role of transcription factors in control and regulation of liver growth, regeneration and differentiation. His studies focus on how growth factors, extra-cellular matrix, or chemicals alter the transcriptional program and affect cellular differentiation and fate. Of particular interest are the liver-enriched transcription factors especially Hepatic Nuclear Factor-4, a key liver transcription factor required for liver development and function.
Selected Publications:
Kolher, C, Bell, AW, Bowen, WC, Monga, SP, Michalopoulos, GK. Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Hepatology 39(4), 1056-65 2004.
Bell, A. W. and Michalopoulos, G. K. Phenobarbital Induces Expression of HNF4 and Hepatic Differentiation Markers via a CAR independent Mechanism. (2004)
Wang X, DeFrances MC, Dai Y, Pediaditakis P, Johnson C, Bell A, Michalopoulos GK, Zarnegar R. A mechanism of cell survival: sequestration of Fas by the HGF receptor Met. Mol Cell. Feb;9(2):411-21 (2002).
Monga SP, Mars WM, Pediaditakis P, Bell A, Mule K, Bowen WC, Wang X, Zarnegar R, Michalopoulos GK. Hepatocyte Growth Factor Induces Wnt-independent Nuclear Translocation of beta-Catenin after Met-beta-Catenin Dissociation in Hepatocytes. Cancer Res. ;62(7):2064-71 (2002).
Bell, A. W., Chen, Q., DeFrances, M. C., Michalopolous, G. K., Zarnegar, R. The five amino acid-deleted isoform of hepatocyte growth factor promotes carcinogenesis in transgenic mice. Oncogene 18, 887-895 (1999).
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