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Research Interests:
Despite improved immunosuppression protocols, most transplant recipients face a variety of complications. Early post-transplant is important to discriminate between infection and rejection. Drug toxicity, chronic rejection and malignancies are long-term complications. Dr. Zeevi's research interests are focused in the area of immunologic monitoring of solid organ transplant recipients. Various cellular assays are performed to determine the host immune status/ pre- and post-transplant, evaluation of T helper cell function, characterization of graft infiltrating lymphocytes and the cytokine profile associated with various clinical conditions. The impact of cytokine gene polymorphism in solid organ transplantation and the predictive value for individualized immunosuppressive protocols.
Dr. Zeevi is also interested in characterization of the immune response to various pathogens in non-transplant and immunocompromised solid organ transplant recipients. In addition, our laboratory is involved in studies on the role of cell migration and chimerism in solid organ transplant acceptance and tolerance induction. Another area of research is mechanisms of action of new immunosuppressive drugs, their in vitro potency when used alone or in combination with other immunosuppressive drugs.
Selected Publications:
View Dr., Zeevi's publications on PubMed.
Di Filippo S, Girnita A, Webber SA, Tsao S, Boyle GJ, Miller SA, Gandhi SK, Zeevi A. Impact of ELISA-Detected Anti-HLA Antibodies on Pediatric Cardiac Allograft Outcome. Hum Immunol. 2005 May;66(5):513-8. Epub 2005 Feb 26.
Macedo C, Donnenberg A, Popescu I, Reyes J, Abu-Elmagd K, Shapiro R, Zeevi A, Fung JJ, Storkus WJ, Metes D. EBV-specific memory CD8(+) T cell phenotype and function in stable solid organ transplant patients. Transpl Immunol. 2005 Jun;14(2):109-16.
Chen A, Li HS, Hebda PA, Zeevi A, Swarts JD. Gene expression profiles of early pneumococcal otitis media in the rat. Int J Pediatr Otorhinolaryngol. 2005 May 24; [Epub ahead of print]
Adeyi OA, Girnita AL, Howe J, Marrari M, Awadalla Y, Askar M, Martell J, Zeevi A, Shapiro R, Nalesnik M, Randhawa P, Demetris AJ, Duquesnoy RJ. Serum analysis after transplant nephrectomy reveals restricted antibody specificity patterns against structurally defined HLA class I mismatches.
Transpl Immunol. 2005 Mar;14(1):53-62.
Zheng HX, Zeevi A, McCurry K, Schuetz E, Webber S, Ristich J, Zhang J, Iacono A, Dauber J, McDade K, Zaldonis D, Lamba J, Burckart GJ.
The impact of pharmacogenomic factors on acute persistent rejection in adult lung transplant patients. Transpl Immunol. 2005 Mar;14(1):37-42.
Shapiro R, Basu A, Tan H, Gray E, Kahn A, Randhawa P, Murase N, Zeevi A, Girnita A, Metes D, Ness R, Bass DC, Demetris AJ, Fung JJ, Marcos A, Starzl TE. Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with Thymoglobulin or Campath. J Am Coll Surg. 2005 Apr;200(4):505-15;
Sindhi R, Manavalan JS, Magill A, Suciu-Foca N, Zeevi A. Reduced immunosuppression in pediatric liver-intestine transplant recipients with CD8+CD28- T-suppressor cells. Hum Immunol. 2005 Mar;66(3):252-7.
Zheng H, Schuetz E, Zeevi A, Zhang J, McCurry K, Webber S, Iacono A, Lamba J, Burckart GJ. Sequential analysis of tacrolimus dosing in adult lung transplant patients with ABCB1 haplotypes. J Clin Pharmacol. 2005 Apr;45(4):404-10.
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