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Research Interests:
Dr. Zarnegar's research interests lie in understanding the cellular and molecular biology of a polypeptide growth factor called Hepatocyte Growth Factor (HGF). The focus of his lab is to dissect the regulatory regions of the HGF and Met (the HGF receptor) genes. He also investigates the physiological function of HGF in normal and neoplastic tissues. He utilizes techniques such as transgenic mice, gene targeting, and other molecular biology techniques.
Selected Publications:
Wang, X. Defrances, M.C., Dai, Y. Bell, A., Michalopoulos G.K. and R. Zarnegar (2002). A novel mechanism of cell survival: sequestration of the death receptor Fas by direct physical association with the tyrosine kinase receptor Met. Molecular Cell 9:411-422.
Jiang, J-G, Johnson, C., and R. Zarnegar (2001). PPAR-gamma-mediated transcriptional upregulation of the HGF gene promoter via a novel composite cis-acting element. J. Biol. Chem. 276:25049-25056.
Seol, D-W., Chen, Q., and R. Zarnegar (2000). Transcriptional activation of the met protooncogene by its ligand HGF is mediated through AP1. Oncogene 19:1132-1137.
Jiang, J-G., Gao B., and R. Zarnegar (2000). The concerted regulatory functions of the transcription factors NF1 and USF family on a composite element in the promoter of the HGF gene. Oncogene 19:2786-2790.
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