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Research Interests:
Dr. Yousem is a Professor of Pathology at the University of Pittsburgh Medical Center. He has a special interest in inflammatory lung disease and lung transplantation, which originated during his residency at Stanford University Medical Center under the guidance of Thomas V. Colby, M.D. and the late Charles B. Carrington, M.D. Following a surgical pathology fellowship and a junior staff position at Stanford, Dr.Yousem spent two years in the Division of Pulmonary and Mediastinal Pathology at the Armed Forces Institute of Pathology. In 1987 he joined the Pathology Department at the University of Pittsburgh Medical Center, and he now marries his responsibilities in pulmonary pathology with responsibilities as Director of Anatomic Pathology. He has a primary interest in interstitial and small airway inflammatory processes of the lung, and the histopathologic alterations of acute rejection and bronchiolitis obliterans in lung allografts. Most recently, with colleagues Sanja Dacic, Yuri Nikiforov, and Marina Nikiforova, he has embarked on multiple projects focused on utilizing molecular assays to develop histomolecular correlations on pulmonary neoplasia, and to identify molecular predictors of biologic behavior and therapeutic responsiveness. These interests have culminated in a large body of scientific publications and numerous invited lectureships and courses in national and international societies and forums. Dr. Yousem also manages the thoracic pathology fellowship - a one to two year intense learning experience in pulmonary pathology.
Selected Publications:
View Dr. Yousem's publications on PubMed.
Tochigi N, Dacic S, Nikiforova M, Cieply KM, Yousem SA. Adenosquamous carcinoma of the lung: a microdissection stud of KRAS and EGFR mutational and amplification status in a western patient population. Am J Clin Pathol 135(5): 783-9, 2011.
Yousem SA, Faber C. "Histopathology of aspiration pneumonia not associated with food or other particulate matter: a clinicopathologic study of 10 cases diagnosed on biopsy." Am J Surg Pathol 35(3): 426-431, 2011.
Yousem, Samuel A, Gibson, Kevin, Kaminski, Naftali, Oddis, Chester V, Ascherman, Dana P. The Pulmonary Histopathologic Manifestations of the anti-Jo-1 tRNA Synthetase Syndrome. Mod Pathol 23(6):874-880, 2010.
Achcar RD, Nikiforova MN, Dacic S, Yousem SA Micropapillary Lung Adenocarcinoma: EGFR, KRAS, and BRAF Mutational Profile. Am J Clin Pathol 131:694-700, 2009.
Achcar RD, Nikiforova MN, Dacic S, Nicholson AG, Yousem SA. Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma. Hum Pathol 40:854-860, 2009.
Konishi K, Gibson KF, Lindell KO, Richards TJ, Zhang Y, Dhir R, Bisceglia M, Gilbert S, Yousem SA, Song J-W, Kim DS, Kaminski N. Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2009 180:167-175, 2009.
Stewart S, Fishbein MC, Snell, GI, Berry GJ, Boehler A, Burke MM, Glanville A, Gould K, Magro C, Marboe CC, McNeil KD, Reed EF, Reinsmoen NL, Scott JP, Studer SM, Tazelaar HD, Wallwork JL, Westall G, Zamora MR, Zeevi A, Yousem SA. Revision of the 1996 working formation for the standardization of nomenclature in the diagnosis of lung rejection. J of Heart and Lung Transpl 26:1229-42, 2007.
Dacic S, Flanagan M, Cieply K, Ramalingam S, Luketich J, Belani C, Yousem SA. Significance of EGFR protein expression and gene amplification in non-small cell lung carcinoma. Am J Clin Pathol. 125(6):860-5, 2006.
Yousem SA. Respiratory bronchiolitis-associated interstitial lung disease with fibrosis is a lesion distinct from fibrotic nonspecific interstitial
pneumonia: a proposal. Mod Pathol 19:1474-79, 2006.
Iacono AT, Johnson BA, Grgurich WF, Youssef JG, Corcoran TE, Seiler DA, Dauber JH, Smaldone GC, Zeevi A, Yousem SA, Fung JJ, Burckart GJ, McCurry KR, Griffith BP. A randomized trial of inhaled cyclosporine in lung-transplant recipients. N Engl J Med 354:141-50, 2006.
Ionescu DN, Girnita AL, Zeevi A, Duquesnoy R, Pilewski J, Johnson B, Studer S, McCurry KR, Yousem SA. C4d deposition in lung allografts is associated
with circulating anti-HLA alloantibody. Transpl Immunol 15:63-8, 2005.
Dacic S, Finkelstein SD, Yousem SA. Clonal selection of adenocarcinoma of the lung as determined by loss of heterozygosity. Experimental and Molecular Pathology 78:135-9, 2005.
Girnita AL, Duquesnoy R, Yousem SA, Iacono AT, Corcoran TE, Buzoianu M, Johnson B, Spichty KJ, Dauber JH, Burckart G, Griffith BP, McCurry KR, Zeevi A. HLA-specific antibodies are risk factors for lymphocytic bronchiolitis and chronic lung allograft dysfunction. Am J Transplant 5:131-8, 2005.
Sasatomi E, Johnson LR, Aldeeb DN, Lomago DM, Thompson Jr JW, Swalsky PA, Luketich JD, Fernando HC, Finkelstein SD, Yousem SA. Genetic profile of cumulative mutational damage associated with early pulmonary adenocarcinoma: BAC vs. Stage I invasive adenocarcinoma. AJSP 28:1280-88, 2004.
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