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Research Interests:
Dr. Yazer's main research focus is in the area of blood group genetics, specifically the ABO blood group system. Using molecular techniques the nature of the alleles underlying weak A and B phenotypes can be elucidated and the resulting enzyme expressed in a bacterial model to facilitate studying its reaction kinetics. These studies provide insights into fundamental questions of glycobiology and enzyme kinetics. Dr. Yazer is also actively involved in studying the coagulation effects of xenotransplantation
Selected Publications:
Polakowski R, Yazer MH, Palcic MM. The Donor Cross-Specificity of Human Blood Group A- and B-Synthesizing Glycosyltransferases. Transfusion Medicine and Hemotherapy 2005;1:5-10.
Yazer MH, Clarke G, Podlosky L, Nahirniak S. The Effect of Prestorage Leukoreduction on the Rates of Febrile Non-Hemolytic Transfusion Reactions to PC and RBC. Transfusion 2004;44:10-5.
Yazer MH, Blajchman M, DiTomasso J, Denomme G. The ABO Sequence Analysis in a Family with Weak Expression of Group B. Transfusion 2004;44:1394-5.
Duck Cho, Soo-Hyun Kim, Mee-Jeong Jeon, Kyeong-Lan Choi, Seung-Jung Kee, Myung-Geun Shin, Jong-Hee Shin, Soon-Pal Suh, MH Yazer, Dong-Wook Ryang. The Serological and Genetic Basis of the cis-AB Blood Group in Korea. Vox Sanguinis 2004;87:41-43.
Duck Cho, Soo-Hyun Kim, Mee-Jeong Jeon, Kyeong-Lan Choi, Seung-Jung Kee, Myung-Geun Shin, Jong-Hee Shin, Soon-Pal Suh, Mark H. Yazer, Dong-Wook Ryang. A Novel Blood Group B Allele Arising from Nucleotide Substitution 547 G>A. Vox Sanguinis 2004;87:187-189.
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