Sally E. Wenzel, MD
Professor of Medicine
Dr. Wenzel is the Director of the University of Pittsburgh Asthma Institute and a member of the Cellular and Molecular Pathology Graduate Training Program.
3459 Fifth Avenue
Pittsburgh PA 15221
Office Telephone: 412-692-2139
- MD - 1981, University of Florida
Clinical ExpertiseDr. Wenzel is considered a global expert in severe asthma. She has pioneered the concept of asthma phenotypes, including the progression to molecular phenotyping. Dr. Wenzel and Dr. Samuel Yousem were the 1st to identify a new disease, termed asthmatic granulomatosis, which has features of asthma and autoimmue-like disease.
Research InterestsDr. Wenzel's research interest derives from her clinical experience. She often follows a bedside to bench approach, regarding biomarkers and relation to asthma phenotypes and treatment. Additionally, she is currently involved in multiple "omics" projects, including gene expression profiling in human airway cell from a range of asthmatics and controls. She is directly involved in better understanding the impact of Type-2 inflammation on human airway epithelial cells and is able to match cultured/esxperimental cells with fresh cells, obtained directly from asthmatic patients. She utilizes these cells to model immune processes in asthma in vitro. She has also been interested in the convergence of additional immune pathways with Type-2 inflammation, particularly that related to Type-1 inflammation.
CertificationsInternal Medicine, Pulmonary Medicine
Awards and Honors
- 2005 - ATS – Elizabeth A. Rich MD Award
- 2005 - Colorado ALA President's Award
- 2010 - American Thoracic Society Recognition Award for Scientific Accomplishment
- 2011 - John E. Salvaggio Memorial Lectureship, AAAAI
- Best Doctors in America 2001 – Present
Selected PublicationsView Dr. Wenzel's publications on PubMed
- Wenzel S, Ford L, Pearlman D, Spector S, Sher L, Skobieranda F, Wang L, Kirkesseli S, Rocklin R, Bock B, Hamilton J, Ming JE, Radin A, Stahl N, Yancopoulos GD, Graham N, Pirozzi G. Dupilumab in Persistent Asthma with Elevated Eosinophil Levels. N Engl J Med 2013 368(26): 2455-2466. PMID:23688323
- Wenzel SE. Asthma phenotypes: Evolution from clinical to molecular approaches. Nat Med. 2012 May 4; 18(5):716-25. PMID: 22561835
- Modena BD, Tedrow JR, Milosevic J, Bleecker ER, Meyers DA, Wu W, Bar-Joseph Z, Erzurum SC, Gaston BM, Busse WW, Jarjour NN, Kaminski N, Wenzel SE. Gene Expression in Relation to Exhaled NO Identifies Novel Asthma Phenotypes with Unique Biomolecular Pathways. Am J Respir Crit Care Med. 2014 Dec 15;190(12):1363-72. PMID: 25338189, PMCID: PMC4294630
- Albano GD, Zhao J, Etling EB, Park SY, Hu H, Trudeau JB, Profita M, Wenzel SE. IL-13 desensitizes ?2 adrenergic receptors in human airway epithelial cells through a 15-Lipoxygenase: G-protein receptor kinase 2 mechanism. JCAI 2015 May;135(5):1144-1153 . PMCID: PMC4426258
- Zhao J, O'Donnell VB, Balzar S, St Croix CM, Trudeau JB, Wenzel SE. 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. Proc Natl Acad Sci USA. 2011 Aug 23;108-(34):14246-51. PMID: 21831839PMCID: PMC3161579