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CLINICAL EXPERTISE:
Dr. Swerdlow's expertise is in hematopathology with an emphasis on lymph node and related tissue diagnostic hematopathology using a multiparameter approach that incorporates morphology, flow cytometric and immunohistochemical phenotype, cytogenetic, molecular and clinical data. He is also responsible for oversight of the Division's varied clinical activities that include general hematology laboratories, a flow cytometry laboratory and a variety of diagnostic services.
RESEARCH EXPERTISE:
Dr. Swerdlow's research efforts involve the use of a multiparameter approach to better define, diagnose and understand selected B-cell and some T/NK lymphomas and the post-transplant lymphoproliferative disorders. Areas of investigation include the following (some in collaboration with other investigators either at the University of Pittsburgh or elsewhere): multiparameter investigation of B-cell lymphomas with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma, SNP analyses of PTLD, "in situ" follicular lymphomas, T follicular helper cell antigen expression in T and B cell proliferations, plasmacytoid dendritic cells in reactive lymph nodes, gamma-delta intestinal T-cell lymphomas, and high throughput cytogenetic testing.
Selected Publications:
View Dr. Swerdlow's publications on PubMed.
Gradowski, J.F., Jaffe, E.S., Warnke, R., Pittaluga, S., Surti, U., Gole, L., Swerdlow, S.H. Follicular Lymphomas with Plasmacytic Differentiation Include Two Subtypes, Modern Pathology, 2010, 23(1):71-79.
Dufresne, S.D., Felgar, R.E., Sargent, R.L., Surti, U., Gollin, S.M., McPhail, E.D., Cook, J.R., Swerdlow, S.H. Defining the Borders of Splenic Marginal Zone Lymphoma: A Multiparameter Study, Human Pathology, 41:540-551, 2010.
Edinger, J.T., Kant, J.A., Swerdlow, S.H. Cutaneous marginal zone lymphomas have distinctive features and include two subsets, Am J Surg Pathol, 2010, 34(12)1830-1841.
Vernŕndez, V., Salamero, O., Espinet, B., Solé, F., Royo, C., Navarro, A., Camacho, F., Beŕ, S., Hartmann, E., Amador, V., Hernández, L., Agostinelli, C., Sargent, R.L., Rozman, M., Aymerich, M., Colomer, D., Villamor, N., Swerdlow, S.H., Pileri, S.A., Bosch, F., Piris, M.A., Montserrat, E., Ott, G., Rosenwald, A., López-Guillermo, A., Serrano, S., Jares, P., Campo, E. Indolent Mantle Cell Lymphoma Identified by Genomic and Gene Expression Profiling, Cancer Research, 2010, 70:1408-1418.
Hoffner, L., Parks, W.T., Swerdlow, S.H., Carson, J.C., Surti, U. Simultaneous detection of imprinted gene expression (p57KIP2) and molecular cytogenetics (FICTION) in the evaluation of molar pregnancies, J. Reprod Med, 2010 May-Jun; 55(5-6):219-28.
Craig, F.E., Ohori, N.P., Gorrill, T., and Swerdlow, S.H. Flow Cytometric Immunophenotyping of Cerebrospinal Fluid Specimens, American Journal of Clinical Pathology, 135:22-34, 2011.
Visco, C., Malik, J.T., Hoeller, S., Xu-Monette, Z.Y., Wiggins, M.L., Liu, J., Sanger, W.G., Chang, J., Ranheim, E.A., Swerdlow, S.H., Gradowski, J.D., Serrano, S., Gascoyne, R.D., Chan, W.C., Liu, Z., Campo, E., Wang, H-Y., Liu Q., Dave, S., Olsen, B., Tzankov, A., Young, K.H. Molecular Characteristics of Mantle Cell Lymphoma Presenting with Clonal Plasma Cell Component. Am J Surg Pathol, 35(2)177-189, 2011.
Gibson, S.E., Swerdlow, S.H., Felgar, R.E. Natural killer (NK) cell subsets and NK-like T-cell populations in benign and neoplastic B-cell proliferations vary based on clinicopathologic features, Human Pathology, 2011:42:679-87.
Gibson, S.E., Swerdlow, S.H., Ferry, J.A., Surti, U., Dal Cin, P., Harris, N.L., Hasserjian, R.P. Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis (MBL), Haematologica 2011;96(8):1144-1152.
Edinger, J.T., Lorenzo, C.R., Breneman, D.L., Swerdlow, S.H. Primary cutaneous marginal zone lymphoma with subclinical cutaneous involvement and biclonality, J Cut Pathol, 2011:38:724-730.
Gibson, S.E., Swerdlow, S.H., Craig, F.E., Surti, U., Cook, J.R., Nalesnik, M.A., Lowe, C., Wood, K.M., Ranganathan, S., and Bacon, .M. EBV-positive extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in the post-transplant setting: a distinct type of post-transplant lymphoproliferative disorder? Am J Surg Pathol, 2011:35(6):807-815.
Pongpruttipan, T., Sukpanichnant, S., Assanasen, T., Wannakrairot, P., Boonsakan, P., Kanoksil, W., Kayasut, K., Mitarnun, W., Khuhapinant, A., Bunworasate, U., Puavilai, T., Bedavanija, A., Garcia-Herrera, A., Campo, E., Cook, J., Choi, J., Swerdlow, S.H. Extranodal NK/T-cell Lymphomas, Nasal Type, includes cases of natural killer cell, αβ, γδ, and αβ/γδ T-cell Origin: a comprehensive clinicopathologic and phenotypic study. Am J Surg Pathol 3 February, 2012. DOI: 10.1097/PAS.obo13e31824433d8.
Gradowski, J.F., Sargent, R.L., Craig, F.E., Cieply, K., Fuhrer, K., Sherer, C., Swerdlow, S.H. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with Cyclin D1 Positive Proliferation Centers Do Not Have CCND1 Translocations or Gains and Lack SOX11 Expression. Am J Clin Pathology, (in press), 2012.
Aggarwal, N., Swerdlow, S.H., Kelly, L.M., Ogilvie, J.B., Sathanoori, M., Nikiforova, M.N., Nikiforov, Y.E. Thyroid carcinoma-associated genetic mutations also occur in thyroid lymphomas. Modern Pathology, (in press), 2012.
Reviews, invited published papers, proceedings of conferences and symposia, monographs, books and book chapters
Swerdlow, S.H., Pathology. In Dharnidharka, V.R., Green, M., Webber, S.A., (Eds.): Transplant Lymphoproliferative Disorders, Springer, 89-104, 2010
Swerdlow, S.H., Craig, F.E.: Iatrogenic immunodeficiency associated lymphoproliferative disorders. In: Jaffe, E.S., Harris, N.L., Vardiman, J.W., Campo, E., Arber, D.A. eds. Hematopathology, Harcourt Health Sciences, 2011, 854-866
Cousar, J.B., Macon, W.R., McCurley, T.L., Swerdlow, S.H. Lymph Nodes. In Mills, S.E., Carter, D., Greenson, J., Reuter, V., Stoler, M., (Eds.): Lymph Nodes, Sternberg's Diagnostic Surgical Pathology, 5th Edition, Wolter Kluwer/Lippincott Williams & Wilkins, 2010, pp. 681-744.
Campo, E., Swerdlow, S.H., Pileri, S., Stein, H., Harris, N.L., Jaffe, E.S. The 2008 WHO Classification of Lymphoid Neoplasms - Evolving Concepts and Practical Applications. BLOOD, 2011:117(19)5019-5032.
Lin, P., Molina, T.J., Cook, J. R., Swerdlow, S.H. Lymphoplasmacytic Lymphoma and Other Non-Marginal Zone Lymphomas With Plasmacytic Differentiation: A report of the 2009 Society for Hematopathology/European Association for Haematopathology Workshop, Am J Clin Pathol 2011;136:195-210.
Molina, T.J., Pei, L., Swerdlow, S.H., Cook, J.R. Marginal Zone Lymphomas With Plasmacytic Differentiation and Related Disorders: A report of the 2009 Society for Hematopathology/European Association for Haematopathology Workshop , Am J Clin Pathol 2011;136:211-225.
Garcia C., Swerdlow S.H. Hematopoietic Tumors of the Breast. In: Dabbs, D. (Ed.) Breast Pathology. Philadelphia: Elsevier; 2012:740-766.
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