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Research Interests:
There are two main areas of research in Dr. Strom's laboratory, and both involve the liver. The first examines the role of growth factors and growth factor receptor systems in the development and progression of cancer. Recent results indicate that the expression of new growth factor pathways and the communication between existing growth factor pathways are two mechanisms by which growth control regulation is lost in cancerdevelopment. In other studies we have determined that the regulation of the expression of the cytochrome P450 genes in human liver is strikingly different from that observed in animal models. We have recently identified ethanol as a potent inducer of the CYP3Afamily of human genes. The induction of CYP3A by ethanol is most likely the basis for adverse effects of ethanol consumption on acetaminophen toxicity in humans. Currentstudies involving the examination of the promotor sequences of the human P450 genes have identified several regions of the DNA, to which protein binding can be demonstrated, which are thought to control gene expression.
Selected Publications:
Tian, H., Ou, J., Aaron, J, Strom, S, Venkataramanan, R., Pharmacokinetics of Tacrolimus and mycophenolic acid are altered, but recover at different times during hepatic regeneration. Drug Metabolism and Dispos. 33:329-335, 2005.
Fang, H-L, Strom, S.C, Cai, H., Kocarek, T.A., and Runge-Morris, M. (2005) Regulation of human hepatic hydroxysteroid sulfotransferase expression by the peroxisome proliferators activated receptor alpha transcription factor. Molecular Pharmacology 67:1257-1267.
Gross-Steinmeyer, K, Stapleton, P.L., Liu, F., Bammler, T.K., Buhler, D.R., Safe, S.H., Strom, S.C., and Eaton, D.L. (2004) Phytochemical-induced changes in gene expression of carcinogen-metabolzing enzymes in cultured human hepatocytes. Xenobiotica, 34:619-632.
Ambrosino, G., Varotto, S. Strom, S.C., Guariso, G., Franchin, E., Miotto, D., Caenazzo, L., Basso, S., Carraro, P., Valenti, M.L., D’Amico, D., Zancan, L D’ Antiga, L.D..(2005) Isolated hepatocyte transplantation for Crigler-Najjar Syndrome, Type 1. Cell Transplantation 14: 151-157.
Feng, Y., Zhang, S., Poloyac, S., Strom, S.C., Venkataramanan, R. (2005) Determination of 13-O-demethyl tacrolimu in human liver microsomal incubatates using liquid chromatography-mass spectrophotometric assay (LC-MS) J. Chromatogr B. Analyt. Technol. Biomed Life Sci. 5: (821) 31-37.
Miki, T. Lehmann, T, Cai, H, Stolz, D.B., Strom, S.C. (2005) Stem cell characteristics of amniotic epithelial cells. Stem Cells, (In Press).
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