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Research Interests:
Dr. Shurin's research interests are in determining the mechanisms of interaction between the tumors and the immune system. The main focus is the analysis of factors and mechanisms that affect differentiation, function and longevity of dendritic cells in the tumor microenvironment and in cancer patients. Based on these studies, novel immunotherapeutic approaches for cancer treatment are proposed.
Selected Publications:
View Dr. Shurin's publications on PubMed.
Shurin GV, Ferris R, Tourkova IL, Perez L, Lokshin A, Balkir L, Collins B, Chatta GS, Shurin MR. Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo. J Immunol. 2005 May 1;174(9):5490-8.
Shurin GV, Tourkova IL, Chatta GS, Schmidt G, Wei S, Djeu JY, Shurin MR. Small rho GTPases regulate antigen presentation in dendritic cells.
J Immunol. 2005 Mar 15;174(6):3394-400.
Whiteside TL, Stanson J, Shurin MR, Ferrone S. Antigen-processing machinery in human dendritic cells: up-regulation by maturation and down-regulation by tumor cells. J Immunol. 2004 Aug 1;173(3):1526-34.
Guruli G, Pflug BR, Pecher S, Makarenkova V, Shurin MR, Nelson JB. Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops. Blood. 2004 Oct 1;104(7):2107-15. Epub 2004 Jun 22.
Song EY, Shurin MR, Tourkova IL, Chatta G, Shurin GV. Human renal cell carcinoma inhibits dendritic cell maturation and functions.
Urologe A. 2004 Sep;43 Suppl 3:128-30
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