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Research Interests:
Dr Rosendorff's research focusses on Epstein-Barr virus (EBV) -host interactions. His laboratory seeks to define ways in which viral proteins modify the unfolded protein, PKR, and autophagy pathways to allow continued cell proliferation in the setting of viral latency, as well as the host signalling pathways required for EBV reactivation. His lab employees genetic, proteomic and cell biology approaches in understanding EBV pathophysiology. A secondary research focus is transgene induction of B-cell leukemogenesis in hematopoetic stem cell models.
Selected Publications:
View
Dr. Rosendorff 's publications on PubMed.
Rosendorff A, Illanes D, David G, Lin J, Kieff E, Johannsen E. EBNA3C coactivation with EBNA2 requires a SUMO homology domain. J Virol. 2004 Jan;78(1):367-77.
Rosendorff A, Sakakibara S, Lu S, Kieff E, Xuan Y, DiBacco A, Shi Y, Shi Y, Gill G NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5308-13. Epub 2006 Mar 27.
Portal D, Rosendorff A, Kieff E. Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19278-83. Epub 2006 Dec 11.
Garrido JL, Rosendorff A, EBNA3C interacts with Gadd34 and counteracts the unfolded protein response, (submitted)
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