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Research Interests:
Dr. Reyes-Múgica has been involved in studies of childhood tumors and defects of neural crest cell migration. We have studied neuroblastoma, a neural crest derived neoplasm with heterogeneous biology and clinical behavior, in which the therapeutic advances have developed with difficulty. We also study another neural crest disorder called neurocutaneous melanosis. Patients with this condition are born with large pigmented nevi (moles) and later develop meningeal/brain melanocytic proliferations. As a member of the Scientific Advisory Board of Nevus Outreach, Inc., a consultation service for conditions related to Giant Melanocytic Nevi and Neurocutaneous Melanosis is offered. A third condition within our interests is Hirschsprung disease (congenital megacolon), in which neural crest-derived ganglion cells are not present in the colonic nervous system, leading to chronic constipation. Studies to improve our diagnostic ability are being conducted.
Selected Publications:
View Dr. Reyes-Múgica's publications on PubMed
Cajaiba MM, Benjamin D, Halaban R,Reyes-Mugica M. Metastatic Peritoneal Neurocutaneous Melanocytosis. Am J Surg Pathol 2008 Jan;32(1):156-161
Gwin K, Cajaiba M, Caminoa-Lizarralde A, Picazo M, Nistal M, Reyes-Mugica M. EXPANDING THE CLINICAL SPECTRUM OF FRASIER SYNDROME. Pediatr Dev Pathol. 2007 Mar 22;:1 [Epub ahead of print]
Cheng E, Trombetta SE, Kovacs D, Beech RD, Ariyan S, Reyes-Mugica M, McNiff JM, Narayan D, Kluger HM, Picardo M, Halaban R. Rab33A: Characterization, Expression, and Suppression by Epigenetic Modification. J Invest Dermatol. 2006 Jun 29; [Epub ahead of print] PMID: 16810302
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