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CLINICAL EXPERTISE:
- Pediatric Tumors: I have been involved in Children's Oncology group for several years and have been part of the Ewings sarcoma study as well as current hepatoblastoma reviewer for pathology. I am also the Institutional PI for Pathology for COG. I am part of a panel of International Pediatric Liver tumor Classification and member of the COG Liver tumor Subcommittee.
- Pediatric Liver and small bowel transplant pathology and pathology of Post-transplant complications including posttransplant lymphoproliferative diseases and smooth muscle tumors.
- Pediatric GI diseases specifically inflammatory bowel disease (part of CHP IBD division), intractable diarrheas of infancy and Hirschsprung's disease
- Pediatric Medical Renal Diseases
- Pediatric infectious diseases
RESEARCH EXPERTISE:
- Hepatoblastomas and other pediatric liver tumors: I have been involved in the study of pediatric liver tumors with emphasis on Wnt signaling pathway and application of immunohistochemical techniques to differentiate various pediatric liver tumors and subtypes of hepatoblastomas. Collaboration with Dr. SP Monga. Part COG funded (NIH)
- Immunohistochemical study of non-neoplastic liver disease: I have been studying the Wnt signalling pathway as well as utility of glypican 3 in pediatric liver diseases. Collaboration with Dr. Monga
- Inflammatory bowel disease: Co-investigator with Dr. O. Finn on MUC1 in inflammatory bowel disease grant. Also collaborated with CMU and dr. Finn's lab to study MRI diagnosis of IBD in rat models
- Pediatric Small bowel transplant: Cellular mechanisms of small bowel transplant rejection. Collaboration with Dr. R. Sindhi.
- Pediatric tumors including germ cell tumors, Wilms tumors and soft tissue tumors. Application of immunohistochemical markers
- Posttransplant tumors including Hodgkin's-like PTLD and Hodgkin's lymphoma and smooth muscle tumors.
PUBLICATIONS:
Sivagnanam M, Schaible T, Szigeti R, Byrd RH, Finegold MJ, Ranganathan S, Gopalakrishna GS, Tatevian N, Kellermayer R. Further evidence for EpCAM as the gene for congenital tufting enteropathy. Am J Med Genet A. 2010 Jan;152A(1):222-4.
Nayyar N, Mazariegos G, Ranganathan S, Soltys K, Bond G, Jaffe R, Sun Q, Nucci A, Kosmach B, Squires R, Abu-Elmagd K, Sindhi R. Pediatric small bowel transplantation. Semin Pediatr Surg. 2010 Feb;19(1):68-77.
Beatty PL, Narayanan S, Gariépy J, Ranganathan S, Finn OJ. Vaccine against MUC1 Antigen Expressed in Inflammatory Bowel Disease and Cancer Lessens Colonic Inflammation and Prevents Progression to Colitis-Associated Colon Cancer. Cancer Prev Res (Phila Pa). 2010 APR, 3(4): 438-46. Epub 2010, MAR23
PMID: 20332301
Girnita DM, Ohmann EL, Brooks MM, Webber SA, Burckart GJ, Ferrell RE, Ranganathan S, Chinnock R, Canter C, Addonizio L, Bernstein D, Kirklin JK, Naftel DC, Zeevi A. Gene polymorphisms impact the risk of rejection with hemodynamic compromise: a multicenter study. Transplantation. 2011 Jun 27;91(12):1326-32. PMID: 21659963.
Vaideeswar P, Bavdekar SB, Biswas P, Sarangarajan R, Bhosale A. Viral ventilator-associated pneumonia: uncovering tip of the iceberg. Indian J Pathol Microbiol. 2011 Apr-Jun, 54(2):339-343.
Ashokkumar C, Ningappa M, Ranganathan S, Higgs BW, Sun Q, Schmitt L, Snyder S, Dobberstein J, Branca M, Jaffe R, Zeevi A, Squires R, Alissa F, Shneider B, Soltys K, Bond G, Abu-Elmagd K, Humar A, Mazariegos G, Hakonarson H, Sindhi R. Increased Expression of Peripheral Blood Leukocyte Genes Implicate CD14(+) Tissue Macrophages in Cellular Intestine Allograft Rejection. Am J Pathol. 2011 Aug [Epub ahead of print] PMID: 21854741.
Li H, Wolfe A, Septer S, Edwards G, Zhong X, Bashar Abdulkarim A, Ranganathan S, Apte U. Deregulation of Hippo kinase signalling in Human hepatic malignancies. Liver Int. 2011 Oct 20. doi: 10.1111/j.1478-3231.2011.02646.x. [Epub ahead of print] PMID:22098159 .
Sindhi R, Ashokkumar C, Higgs BW, Gilbert PB, Sun Q, Ranganathan S, Jaffe R, Snyder S, Ningappa M, Soltys KA, Bond GJ, Mazariegos GV, Abu-Elmagd K, Zeevi A. Allospecific CD154?+?T-cytotoxic memory cells as potential surrogate for rejection risk in pediatric intestine transplantation. Pediatr Transplant. 2011 Nov 29. doi: 10.1111/j.1399-3046.2011.01617.x. [Epub ahead of print]. PMID:22122074.
Kadayakkara DK, Ranganathan S, Young WB, Ahrens ET. Assaying macrophage activity in a murine model of inflammatory bowel disease using fluorine-19 MRI. Lab Invest. 2012 Feb 13. doi:10.1038/labinvest.2012.7. (Epub ahead of print)
Beatty P, Ranganathan S, Finn OJ. Prevention of colitis-associated colon cancer using a vaccine to target abnormal expression of the MUC1 tumor antigen. Oncoimmunology. 2012: 1(3) May/June, 1-8.
Furr A, Ranganathan S, Finn OJ. Aberrant Expression of MUC1 in pediatric inflammatory bowel disease. Pediatr Dev Pathol. 2010 Jan 13(1):24-31. PMID: 19025220
Luo JH, Ren B, Keryanov S, Tseng GC, Rao UNM, Monga SP, Strom S, Demetris AJ, Nalesnik M, Yu YP, Ranganathan S, Michalopoulos GK. Transcriptomic and Genomic analysis of hepatocellular carcinomas and hepatoblastomas. Hepatology 2006; 44: 1012-1024.
Ranganathan S, Tan X, Monga SP. Beta-catenin and Met deregulation in childhood hepatoblastomas. Pediatr Dev Pathol 2005; 8(4): 435-447.
Ranganathan S, Webber S, Ahuja S, Jaffe R. Hodgkin's-like posttransplant lymphoproliferative disorder in children: Does it differ from posttransplant Hodgkin's lymphoma? Pediatr Dev Pathol. 2004; 7 (4): 348-360
Sarangarajan R, Hill DA, Humphrey PA, Hitchcock MG, Dehner LP, Pfeifer JD. Primitive neuroectodermal tumors of the biliary and gastrointestinal tracts: clinicopathologic and molecular diagnostic study of two cases. Pediatr Dev Pathol 2001; 4: 185-191.
Sarangarajan R, Dehner LP. Cranial and extracranial fasciitis of childhood: a clinicopathologic and immunohistochemical study. Hum Pathol. 1999; 30: 87-92.
Sarangarajan R., Ranganathan A, Belmonte AH, Tchertkoff V. Strongyloides stercoralis infection in AIDS. A review. AIDS Patient Care and STDs. 1997; 11:6, 407-414.
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