Jan Pilch, MD
Assistant Professor of Urology
Dr. Pilch is a member of the Cellular and Molecular Pathology Graduate Training Program.
UPMC Shadyside, Suite G33
5200 Centre Avenue
Pittsburgh, PA 15232
Office Telephone: 412-623-3917
Lab Telephone: 412-623-3926
- MD - University of Giessen, Germany, 1997
Research InterestsMy work is devoted to understanding cell adhesion and extracellular matrix biology as it relates to blood clotting, angiogenesis and tumor metastasis. Building on recent work from my laboratory regarding the prometastatic function of fibrin-fibronectin complexes, I am interested in elucidating the role of clotted plasma and tumor cell integrin ανβ3 for kidney cancer metastasis.
The second project in my laboratory focuses on the molecular analysis of the tumor homing peptide CLT1 that we identified by screening a phage library on clotted plasma. CLT1 binds to fibronectin as well as CLIC family proteins that are specifically expressed on the surface of angiogenic endothelium and tumor cells. Currently, these interactions are being translated into theranostic nanoplatforms for targeting tumor angiogenesis in general and bladder cancer in particular.
Awards and HonorsFellowship of the German Research Council
Selected PublicationsView Dr. Pilch's publications on PubMed
- J. Pilch, R. Habermann, B. Felding-Habermann: Unique ability of integrin ανβ3 to support tumor cell arrest under dynamic flow conditions. J.Biol.Chem.277(24): 21930-21938, 2002.
- M.E. Akerman*, J. Pilch*, D. Peters, E. Ruoslahti: Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature. Proc Natl Acad Sci U S A, 102(6): 2040-2045, 2005.
*M.E. Akerman and J. Pilch contributed equally
- J. Pilch, D.M. Brown, M. Komatsu, T.A.H. Jarvinen, M. Yang, D. Peters, R.M. Hoffman, E. Ruoslahti: Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds. Proc Natl Acad Sci U S A, 103(8): 2800-2804, 2006.
- Gunjan Malik, Lynn M. Knowles, Rajiv Dhir, Shuping Xu, Shuting Yang, Erkki Ruoslahti and Jan Pilch. Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion. Cancer Research, 70(11):4327-34, 2010.
- J. Liu, L.E. Pascal, S. Isharwal, D. Metzger, R. Ramos Garcia, J. Pilch, S. Kasper, K. Williams, P.H. Basse, J.B. Nelson, P. Chambon, Z. Wang. Regenerated luminal epithelial cells are derived from pre-existing luminal epithelial cells in adult mouse prostate during androgen manipulation. Mol Endocrinol. (11):1849-57, 2011.
- Lynn M. Knowles, Gunjan Malik, Brian L. Hood, Thomas P. Conrads, Jan Pilch. CLT1 targets angiogenic endothelium through CLIC1 and fibronectin. Angiogenesis. 2012;15(1):115-29.
- Bishoy A. Gayed , Katherine J. O’Malley, Jan Pilch and Zhou Wang. Digoxin Inhibits Blood Vessel Density and HIF-1α Expression in Castration-Resistant C4-2 Xenograft Prostate Tumors. Clin Transl Sci. 2012 Feb;5(1):39-42.