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Research Interests:
Sepsis
- Tolerance signaling mechanisms of the innate and adaptive immune system
- Genetic and Inflammatory markers of Apoptosis
- Disparities in Sepsis: Biological and Socio-economic factors
Clinical Chemistry
- Intra-individual variation of chemistry analytes in the Pediatric population
- Laboratory Automation
Selected Publications:
Peck OM, Fan Tempel G, Teti G, Haluska P, Cook J. Staphylococcus aureus and Lipopolysaccharide Induce Homologous Tolerance but Heterologous Priming: Role of Interferon- . Shock 21:254-260, 2004.
Peck OM, Williams D, Breuel K, Kalbfleisch J, Fan H, Tempel G, Teti G, J, Cook JA. Differential Regulation of cytokine and chemokine production in lipopolysaccharide induced tolerance and priming. Cytokine 26: 202-208, 2004.
Fan H, Peck OM, Tempel G, Halushka PV, and James A. Cook. "Toll-like receptor 4 (TLR4) coupled Gi protein signaling pathways regulate extracellular signal-regulated kinase (ERK1/2) phosphorylation and AP-1 activation independent of NF B activation." Shock 22: 57-62, 2004.
Fan H, Peck OM, Tempel G, Halushka PV, and James A. Cook. Lipopolysaccharide and Gram-positive Bacteria Induced Cellular Inflammatory Responses: Role of Heterotrimeric G i Proteins. Am J Physiol Cell Physiol 289:C293-301, 2005.
Peck OM, Fan H, Tempel G, Teti G, Halushka PV, and James A. Cook. The Phosphatidylinositol 3 kinase Pathway Regulates Tolerance To Lipopolysaccharide and Priming Responses To Staphylococcus aureus and Lipopolysaccharide. Shock 26:31-36, 2006.
Palmer O, Grenache DG, Gronowski A. Review of the NACB Laboratory Medicine Practice Guidelines for Point of Care Reproductive Testing. Point of Care: The Journal of Near-Patient Testing & Technology 6:265-272, 2007.
Peck Palmer O, Jacqueline Unsinger, Katherine C. Chang, Christopher Davis, Jonathan McDunn, Richard S. Hotchkiss. Deletion of MyD88 Markedly Attenuates Sepsis-Induced T and B Lymphocyte Apoptosis But Worsens Survival. J Leukoc Biol 83:1009-1018, 2008.
Schwulst S, Munser J, Peck Palmer O, Unsinger J, Chang KC, McDunn J, Hotchkiss RS. "BIM siRNA Decreases Lymphocyte Apoptosis and Improves Survival in Sepsis" Shock 2008 Jan 9. [Epub ahead of print] PMID: 18197142.
Peck Palmer O, Unsinger J, Chang KC, McDunn J, Hotchkiss RS. Modulation of Bcl-2 Family Blocks Sepsis-Induced Depletion of Dendritic Cells and Macrophages Shock (Accepted).
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