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Research Interests:
Dr. Ozolek's scientific interests center on image analysis for the detection of specific tissue types and classification of challenging diagnostic dilemmas in surgical pathology. He has extensive collaborations with Drs. Kovacevic and Rohde at the Center for Bioimage Informatics at Carnegie Mellon University to develop algorithms and computational approaches for automating tissue recognition and correlation of histology and high-resolution magnetic resonance images in teratomas derived from human and non-human primate stem cells, and to developing computational morphometric technology for applications in cell biology and medicine. His clinical and diagnostic research interests focus on the role of stem cells and migrational abnormalities of neural crest in the pathogenesis of branchial cleft cysts, other developmental abnormalities, and tumors in the head and neck of children. Other interests include strong collaborations with the laboratories of Dr. Benjamin Shneider investigating the role of c-fos in ileal injury and bile acid transport and Dr. David Hackam in the Department of Pediatric Surgery that has resulted in several publications and grant submissions on the role of Toll-like receptors in the pathogenesis of necrotizing enterocolitis.
Selected Publications:
View
Dr. Ozolek's publications on PubMed.
Richardson WM, Sodhi CP, Russo A, Siggers RH, Afrazi A, Gribar SC, Neal MD, Dai S, Prindle T Jr, Branca M, Ma C, Ozolek J, Hackam DJ. Nucleotide-Binding Oligomerization Domain-2 Inhibits Toll-Like Receptor-4 Signaling in the Intestinal Epithelium. Gastroenterology. 2010 Sep;139(3):904-917.e6. Epub 2010 May 24.
Castro CA, Ben-Yehudah A, Ozolek JA, Mills PH, Redinger CJ, Mich-Basso JD, McFarland DA, Oliver SL, Ahrens ET, Schatten G. Semiquantitative histopathology and 3D magnetic resonance microscopy as collaborative platforms for tissue identification and comparison within teratomas derived from pedigreed primate embryonic stem cells. Stem Cell Res 2010;3:201-11.
Mindikoglu AL, King D, Magder LS, Ozolek JA, Mazariegos GV, Shneider BL. Valproic Acid-Associated Acute Liver Failure in Children: Case Report and Analysis of Liver Transplantation Outcomes in the United States. J Pediatr. 2010 Dec 15.
Houshmand G, Hosseinzadeh K, Ozolek J. Prenatal magnetic resonance imaging (MRI) findings of a foregut duplication cyst of the tongue: Value of real-time MRI evaluation of the fetal swallowing mechanism. J Ultrasound Med. 2011;30:843-50.
Wei Wang, Yilin Mo, John A. Ozolek, Gustavo Kunde Rohde. Characterizing morphology differences from image data using a modified fisher criterion. Proceedings of the IEEE International Symposium on Biomedical Imaging (ISBI 2011).
Cheng Chen, John Ozolek, Wei Wang, Gustavo Rohde. A pixel classification system for segmenting biomedical images using intensity neighborhoods and dimension reduction. Proceedings of the IEEE International Symposium on Biomedical Imaging (ISBI 2011).
Cheng Chen, John A. Ozolek, Wei Wang, and Gustavo K. Rohde. A general system for automatic biomedical image segmentation using intensity neighborhoods. International Journal of Biomedical Imaging Volume 2011 (2011), Article ID 606857, 12 pages doi:10.1155/2011/606857.
Chai RL, Ozolek JA, Branstetter BF, Mehta DK, Simons JP. Congenital choristomas of the oral cavity in children. Laryngoscope. 2011 Aug 8. doi: 10.1002/lary.21758. [Epub ahead of print].
M.L. Massar, R.Bhagavatula, J.A. Ozolek, C.A. Castro, M. Fickus, J. Kovacevic. A domain-knowledge inspired mathematical framework for the description and classification of H&E stained histopathology images. Proceedings SPIE Wavelets & Sparsity XIV, San Diego, CA, August 2011.
John A. Ozolek and Carlos A. Castro. Teratomas derived from embryonic stem cells as models for embryonic development, disease, and tumorigenesis. In Embryonic Stem Cells: Basic Biology to Bioengineering. Michael S. Kallos ed. pp 231-262. ISBN 978-953-307-278-4.
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