Tim D. Oury, M.D., Ph.D. Dr. Oury is a member of the Division of Molecular Diagnostics. More information about this division is available here. To see members of Dr. Oury's lab click here. Dr. Oury is co-director of a program designed to transition physician scientist trainees into academic faculty professorships. For more information, please see the Pathologist Investigator Residency Training Program website at http://www.pathology.pitt.edu/PIRT. This combined Residency-Post-doctoral Research Fellowship or combined Residency-PhD program is designed to develop Academic Pathologists to become independent Principal Investigators and to play a leading role in combined research and diagnostic careers. Office Location: Seventh Floor, Scaife Hall 3550 Terrace Street Pittsburgh, PA 15261 Contact Information: Office Phone: (412) 648-9659 Fax: (412) 383-9594 E-mail: tdoury@pitt.edu Research Interests: Research in Dr. Oury's lab is centered on understanding the molecular mechanisms involved in pulmonary fibrosis and acute interstitial lung disease. The laboratory is investigating the role of extracellular oxidants in mediating physiologic and pathologic responses. The enzyme extracellular superoxide dismutase (EC-SOD) has been found to protect against pulmonary fibrosis and prevents inflammatory responses in the lung. The laboratory is investigating mechanisms by which EC-SOD mediates these responses (See Figure). Dr. Oury's laboratory is also investigating the role of the receptor for advanced glycation endproducts (RAGE) in mediating inflammatory and fibrotic responses in the lung. RAGE has been found to mediate pathologic responses in many disease models including diabetes and cancer. We have found that RAGE is highly expressed in the lung compared to other tissues and may mediate responses to many pulmonary injuries. The major research projects available in my laboratory include: Investigating the role of EC-SOD in pulmonary fibrosis. Investigate the interaction of oxidants and proteinases in interstitial lung injury. Investigate the role of RAGE in pulmonary fibrosis. Mechanisms in Neurodegeneration and Learning and Memory. To see members of Dr. Oury's lab click here. For more information on research opportunities see: http://path.upmc.edu/cmp/fac18.htm Research rotation Oxidative mechanisms in pulmonary disease click here Research rotation studying receptor for advanced glycation end products (RAGE) in pulmonary and neurodegenerative diseases click here Selected Publications: View Dr. Oury's Curriculum Vitae. View Dr. Oury's publications on PubMed. Fattman CL, Tan RJ, Tobolewski JM, Oury TD. (2006) Increased sensitivity to asbestos-induced lung injury in mice lacking extracellular superoxide dismutase. Free Rad Biol Med. Tan RJ, Fattman CL, Niehouse LM, Tobolewski JM, Hanford LE, Monzon FA, Li Q, Parks WC, Oury TD. (2006) Matrix Metalloproteinases Promote Inflammation and Fibrosis in Asbestos-induced Lung Injury in Mice. Am. J. Resp. Cell Molec. Biol. 35: 289-97. Gao F, Kinnula VL, Myllärniemi M, Oury TD. (2008) Extracellular superoxide dismutase in pulmonary fibrosis. Antioxid Redox Signa. 10: 343-54. Kliment, CR, Tobolewski, JM, Manni, ML, Tan, RJ, Enghild, JJ, Oury, TD. (2008) Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung. Antioxid Redox Signa. 10: 261-68. Englert JD, Hanford LE, Kaminski N, Tan RJ, Fattman CL, Tobolewski JM, Richards TJ, Loutaev I, Nawroth PP, Kasper M, Bierhaus A, Oury TD. (2008) A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis. Am. J. Pathol. 172: 583-91. Gao F. Koenitzer JR, Tobolewski JM, Jiang D, Liang J, Noble PW, Oury TD. (2008) Extracellular superoxide dismutase inhibits inflammation by preventing oxidative fragmentation of hyaluronan. J. Biol. Chem. 283: 6058-66. Kliment CR, Engert JM, Gochuico B, Yu G, Kaminski N, Rosas I, Oury TD. (2009) Oxidative Stress Alters Syndecan-1 Distribution in the Lung During Pulmonary Fibrosis. J. Biol. Chem. In Press.