Satdarshan (Paul) Singh Monga, MD
Professor of Pathology
Professor in Experimental Pathology
Dr. Monga is the Chair for Experimental Pathology, Vice Chair and Chief of Division of Experimental Pathology, Professor of Pathology (Division of Experimental Pathology), Professor of Medicine (Division of Gastroenterology, Hepatology & Nutrition), Assistant Dean for Medical Scientist Training Program, Director of Cellular Approaches to Tissue Engineering & Regeneration (CATER) Program.
200 Lothrop Street
Pittsburgh PA 15261
Office Telephone: 412-648-2354
- MD - Dayanand Medical College & Hospital, Ludhiana, India, 1993
- Postdoctoral Fellowship - Georgetown University, 1997
- Postdoctoral Fellowship - Temple University, 1999
Research ExpertiseDr. Monga Laboratory Website
Current research projects are aimed at elucidating the cellular and molecular basis of liver growth and development. Specifically my laboratory is focused on elucidating roles of signaling mechanisms such as Wnt/β-catenin, PDGFR and other receptor tyrosine kinases in prenatal and postnatal liver development, liver regeneration after partial hepatectomy or after toxic liver injury. The laboratory is focused on elucidating mechanisms to enhance liver regeneration using modulation of specific signaling pathway. In addition, studies in the lab are ongoing to elucidate mechanisms of repair through hepatic progenitors. Specifically, using models such as DDC injury and bile duct ligation, we are interested in understanding the relevance of specific signaling pathways that induce the ductular reaction and expansion to ultimately promote repair of the damaged liver. Similarly, the lab is also focused on studying pathways that may be exploited to retard hepatic injury or facilitate repair using various preclinical models such as Fas or LPS that mimic clinical diseases such as viral, autoimmune or alcoholic hepatitis. There is ample evidence generated in our lab that pathways such as Wnt/β-catenin signaling may be key regulators of hepatic metabolism as well as injury and thus their modulation can be exploited to benefit repair process due to their divergent effects. Current studies are thus also aimed at understanding the role of -catenin signaling in the metabolism of cholesterol, vitamin C, and bile acid in the liver. The last major interest of my laboratory is to understand the cellular and molecular basis of HCC for therapeutic and prognostic purposes through utilization of animal models of cancer and patient tissues. Again, we have identified key signaling mechanisms that are being characterized for their functions at multiple levels in HCC pathogenesis. Special emphasis is on targeting pathways such as Wnt/β-catenin, PDGFRα, EGFR and Met for treatment of HCC through use of existing and novel inhibitors, either alone or in combinations.
NIH ResearchView Dr. Monga's NIH RePORT on nih.gov
Selected PublicationsView Dr. Monga's publications on PubMed
- Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. Muc1 is Protective during Kidney Ischemia-Reperfusion Injury. Am J Physiol Renal Physiol. 2015 Apr 29:ajprenal.00066.2015.
- Jing Yang, Antonella Cussimano, Jappmann Monga, Morgan Preziosi, Filippo Pullara, Guillerma Calero, Richard Lang, Terry Yamaguchi, Kari Nichole Nejak-Bowen, Monga SP. Wnt5a inhibits hepatocyte proliferation and concludes β-catenin signaling in liver regeneration. American Journal of Pathology. 2015 (In Press).
- Delgado A, Okabe H, Preziosi M, Russell JO, Alvarado TF, Oertel M, Nejak-Bowen KN, Zhang Y, Monga SP. Complete response of Ctnnb1-mutated tumors to β-catenin suppression by locked nucleic antisense in mouse hepatocarcinogenesis model. Journal of Hepatology. J Hepatol. 2015 Feb;62(2):380-7. Accompanying Editorial.
- Bhushan B, Walesky C, Manley M, Gallagher T, Borude P, Edwards G, Monga SP, Apte U. Pro-Regenerative Signaling after Acetaminophen-Induced Acute Liver Injury in Mice Identified Using a Novel Incremental Dose Model. Am J Pathol. 2014 Sep 2. pii: S0002-9440(14)00437-4. doi: 10.1016/j.ajpath.2014.07.019.
- Hirohisa Okabe, Evan Delgado, Jung Min Lee, Jing Yang, Hiroki Kinoshita, Hiromitsu Hayashi, Allan Tsung, Jaideep Behari, Toru Beppu, Hideo Baba, Monga SP. Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma. PLOS ONE 2014 Jun 3;9(6):e98817.
- Junyan Tao, Diego F. Calvisi, Sarangarajan Ranganathan, Antonio Cigliano, Lili Zhou, Sucha Singh, Lijie Jiang, Biao Fan, Luigi Terracciano, Sorin Armeanu-Ebinger, Silvia Ribback, Frank Dombrowski, Matthias Evert, Xin Chen, Monga SP. Wnt/β-catenin and Yap pathways synergize to promote hepatoblastoma development in mice and men. Gastroenterology, 2014 May 14. pii: S0016-5085(14)00610-6.
- Evan Delgado, Jing Yang, Juhoon So, Stephanie Leimgruber, Michael Kahn, Tohru Ishitani, Donghun Shin, Gabriela Mustata Wilson, Monga SP. Identification and characterization of a novel small molecule inhibitor of beta-catenin signaling. American Journal of Pathology, 2014 May 9. (In Press).
- Jing Yang, Laura E. Mowry, Kari Nichole Nejak-Bowen, Hirohisa Okabe, Cassandra R. Diegel, Richard A. Lang, Bart O. Williams, Monga SP. Beta-catenin signaling in murine liver zonation and regeneration: A Wnt-Wnt situation. Hepatology 2014 Feb 20.
- Fanti M, Singh S, Ledda-Columbano GM, Columbano M, Monga SP. Triiodothyronine induces hepatocyte proliferation by protein kinase A-dependent β-catenin activation in rodents. Hepatology 2013, Oct. 07.
- Lee JM, Yang J, Newell PN, Singh S, Parwani A, Friedman SL, Nejak-Bowen KN, Monga SP. Beta-catenin signaling in hepatocellular cancer. Implications in inflammation, fibrosis and proliferation. Cancer Letters, 2013, Sep. 23.
- Delgado E, Bahal R, Yang J, Lee JM, Ly DH, Monga SP. β-Catenin Knockdown in Liver Tumor Cells by a Cell Permeable Gamma Guanidine-based Peptide Nucleic Acid. Curr Cancer Drug Targets. 2013 Oct;13(8):867-78
- Criscimanna A, Duan D, Rhodes JA, Fendrich V, Wickline ED, Hartman DJ, Monga SP, Lotze M, Gittes GK, Fong GH, Esni F. PanIN-specific regulation of Wnt signaling by HIF2. Cancer Res. 2013 Aug 1;73(15):4781-90.
- Nakamura I, Fernandez-Barrena MG, Ortiz-Ruiz MC, Almada LL, Hu C, Elsawa SF, Mills LD, Romecin PA, Gulaid KH, Moser CD, Han JJ, Vrabel A, Hanse EA, Akogyeram NA, Albrecht JH, Monga SP, Sanderson SO, Prieto J, Roberts LR, Fernandez-Zapico ME. Activation of the Transcription Factor GLI1 by WNT Signaling Underlies the Role of SULFATASE 2 as a Regulator of Tissue Regeneration. J Biol Chem. 2013 Jul 19;288(29):21389-98.
- Wickline E, Du Y, Stolz DB, Kahn M, Monga SP. β-Catenin at adherens junctions: Mechanism and biological implications in hepatocellular cancer after β-catenin knockdown. Neoplasia. 2013 Apr;15(4):421-34.
- Awuah P, Nejak-Bowen KN, Monga SP. Role and regulation of PDGFRα in liver development and regeneration. Am J Pathol. 2013 May;182(5):1648-58
- Pullara F, Guerrero-Santoro J, Calero M, Zhang Q, Peng Y, Spahr H, Kornberg GL, Cusimano A, Stevenson HP, Santamaria H, Reynolds SL, Brown IS, Monga SP, Houten BV, Rapic-Otrin V, Calero G, Levine AS. A general path for large-scale solubilization of cellular proteins: From membrane receptors to multiprotein complexes. Protein Expr Purif. 2013 Feb;87(2):111-9.
- Nejak-Bowen KN, Kikuchi A, Monga SP. β-Catenin-NF-κB interactions in murine hepatocytes: A complex to die for. Hepatology 2013 Feb;57(2):763-74.