George K. Michalopoulos, M.D., Ph.D. Dr. George K. Michalopoulos received his medical doctoral degree at Athens University School of Medicine in 1969. A residency in Anatomic Pathology and a Ph.D. in Oncology was obtained at the Wisconsin Medical Center in Madison in 1977. Dr. Michalopoulos moved to Duke University as Assistant Professor in 1977 and stayed at Duke University until 1991. He then moved to Pittsburgh as Professor and Chairman of the Department of Pathology in April, 1991 and he continues to serve in that role. He also served as Associate Vice Chancellor for Health Sciences and Interim Dean of the School of Medicine from November, 1995, until November, 1998. Office Location: Department of Pathology University of Pittsburgh School of Medicine S-410 S-BST Pittsburgh, PA 15261 Contact Information: Office Phone: (412) 648-1040 FAX: (412) 648-9846 Email Address: michalopoulosgk@upmc.edu Research Interests: Growth Factors and Receptors in Hepatocytes Growth Regulation of Human Hepatocytes Hepatic Carcinogenesis Selected Publications: View Dr. Michalopoulos' publications on PubMed Donthamsetty S, Bhave VS, Kliment CS, Bowen WC, Mars WM, Bell AW, Stewart RE, Orr A, Wu C, Michalopoulos GK. Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene. Hepatology. 2011 Feb;53(2):587-95. doi: 10.1002/hep.24040. Epub 2011 Jan 6. Limaye PB, Bowen WC, Orr A, Apte UM, and Michalopoulos GK. Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation. Comp. Hepatol. 2010, Dec; doi: 10.1186/1476-5926-9-9. PMCID: PMC3014870. Michalopoulos GK. Liver Regeneration after Partial Hepatectomy : Critical Analysis of Mechanistic Dilemmas. Am J Pathol. 2010 January; 176(1): 2-13. doi: 10.2353/ajpath.2010.090675. PMCID: PMC2797862. Bae MH, Bissonette GB, Mars WB, Michalopoulos GK, Achim CL, Depireux DA, and Powell EM. Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility Exp Neurol. PMC 2011 January 1. PMCID: PMC2812579. Liu B, Bell AW, Paranjpe S, Bowen WC, Khillan JS, Luo JH, Mars WM, Michalopoulos GK. Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice. Hepatology. 2010, Sep;52(3):1060-7. PubMed PMID: 20812357; PubMed Central PMCID: PMC2936713. Han C, Bowen WC, Li G, Demetris AJ, Michalopoulos GK, Wu T. Cytosolicphospholipase A2alpha and peroxisome proliferator-activated receptor gammasignaling pathway counteracts transforming growth factor beta-mediated inhibitionof primary and transformed hepatocyte growth. Hepatology. 2010 Aug;52(2):644-55. PubMed PMID: 20683962. Zhu ZH, Yu YP, Zheng ZL, Song Y, Xiang GS, Nelson J, Michalopoulos G, Luo JH. Integrin alpha 7 interacts with high temperature requirement A2 (HtrA2) to induceprostate cancer cell death. Am J Pathol. 2010 Sep;177(3):1176-86. Epub 2010 Jul22. PubMed PMID: 20651226; PubMed Central PMCID: PMC2928952.