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Research Interests:
Dr. Luo's research is in the area of genome and gene expression study of maligancies, especially in understanding how prostate cancers obtain invasive and metastatic capability. Dr. Luo's laboratoy in the past has primarily focused on the isolation and characterization of genes whose expressions have been inactivated in prostate cancers. His laboratory has isolated and characterized several candidate genes that might be important for tumor invasion. Ongoing studies in his laboratory focus on defining the roles of these genes in regulating the signaling pathways in normal and cancerous cells. In addition, his laboratory is actively searching new candidate genes that are overexpressed or deleted in tumors, using Affymetrix Chip Array and Differential Subtraction Chain technologies. His group is exploring the possibility of using these genes as diagnostic or prognostic markers for prostate cancers.
In addition, Dr. Luo also serves as Director for the newly established Gene Array Laboratory.
Selected Publications:
- Yan P. Yu, Guoying Yu, George Tseng, Kathleen Cieply, Joel Nelson, Marie Defrances, Reza Zarnegar, George Michalopoulos and Jian-Hua Luo (2007). Glutathione Peroxidase 3, Deleted or Methylated In Prostate Cancer, Suppresses Prostate Cancer Growth and Metastasis. Cancer Research, in press.
- Baoguo Ren, Yan P. Yu, George C. Tseng, Chuanyue Wu, Ka Chen, Uma N. Rao, Joel Nelson, George K. Michalopoulos and Jian-Hua Luo (2007). Analysis of Integrin ¦Á7 Mutations in Prostate Cancer, Liver Cancer, Glioblastoma Multiforme, and Leiomyosarcoma. Journal of National Cancer Institute, 99, 868-880.
- Craig, F.E., Johnson, L.R., Harvey, S.A.K., Nalesnik, M.A., Luo, J.H., Bhattacharya, S.D., and Swerdlow, S.H. (2007). Gene Expression Profiling of Epstain-Bar Virus-Positive and Negative Monomorphic B-Cell Post-transplant Lymphoproliferative Disorders. Diagnostic Molecular Pathology, in press
- Shirish Paranjpe, William C. Bowen, Aaron W. Bell, Kari Nejak-Bowen, Jian-Hua Luo and George K. Michalopoulos (2007). Cell cycle effects caused by inhibition of HGF and its receptor c-met in regenerating rat livers by RNA interference. Hepatology 45, 1471-1477.
- Chiosea S, Jelezcova E, Chandran U, Luo J, Mantha G, Sobol RW, Dacic S. (2007). Overexpression of Dicer in precursor lesions of lung adenocarcinoma. Cancer Res. 67(5):2345-50.
- Yingjian Li, Junwei Yang, Jian-Hua Luo, Shoukat Dedhar and Youhua Liu (2007). Tubular epithelial cells dedifferentiation is driven by helix-loop-helix transcriptional inhibitor Id1. Journal of American Society of Nephrology 18, 449-60.
- Jian-Hua Luo, Baoguo Ren, Sergei Keryanov, George C. Tseng, Uma N.M. Rao, Satdarshan P. Monga, Steven Strom, Anthony J. Demetris, Michael Nalesnik, Yan P. Yu, Sarangarajan Ranganathan and George K. Michalopoulos (2006). Transcriptomic and Genomic analysis of Human Hepatocellular Carcinomas and Hepatoblastomas. Hepatology 44, 1012-1024.
- Yan Ping Yu and Jian-Hua Luo (2006). Myopodin Mediated Suppression of Prostate Cancer Cell Migration Involves Interaction with Zyxin. Cancer Research, 66, 7414-7419.
- Yan Ping Yu, George C. Tseng and Jian-Hua Luo (2006). Inactivation of Myopodin Expression Is Associated with Prostate Cancer Relapse. Urology 68, 578-82.
- Guoying Yu, George C. Tseng, Yan Ping Yu, Tim Gavel, Joel Nelson, Alan Wells, George Michalopoulos, Demetrius Kokkinakis and Jian-Hua Luo (2006). CSR1 Suppresses Tumor Growth and Metastasis of Prostate Cancer. American Journal of Pathology 168, 597-607.
- Baoguo Ren, Guoying Yu, George C. Tseng, Kathleen Cieply, Timothy Gavel, Joel Nelson, George Michalopoulos, Yan Ping Yu and Jian-Hua Luo (2006). MCM7 Amplification and Overexpression Are Associated with Prostate Cancer Progression. Oncogene 25, 1090-1098.
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