John G. Lunz III, PhD
Assistant Professor of Pathology
Dr. Lunz is a member of the Division of Transplantation Pathology and the Assistant Director of the Tissue Typing Laboratory.
5712A South Tower
200 Lothrop Street
Pittsburgh, PA 15213
Office Telephone: 412-647-0462
Lab Telephone: 412-624-6605
- BS - Allegheny College, Meadville, Pennsylvania, 1996
- PhD - University of Pittsburgh School of Medicine, 2007
Clinical ExpertiseMy clinical area of specialty is in Histocompatibility and Immunogenetics. Towards this end, I am currently the Assistant Director of the UPMC Tissue Typing laboratory. The role of the Tissue Typing lab is to supporting all of the solid organ and bone marrow transplant programs at UPMC, Children’s Hospital of Pittsburgh and the Veteran's Administration Hospital in Pittsburgh by testing patients for HLA antibodies both before transplant to facilitate identification of acceptable immunological risk for candidates. Additionally, we also perform HLA antigen typing for donors and recipients to assist clinicians in matching potential bone marrow and solid organ pairings.
Research InterestsMy research interests lie within liver pathophysiology, specifically examining how the gut bacteria colonizing the intestines influence liver immunology. My investigations utilize mouse models either lacking gut flora (germ free mice) or mice with gut bacteria depleted by antibiotics. We are interested in understanding how perturbations in the gut flora can affect the ability of the liver and liver immune cells to respond to injury or stimulation.
A second area of research ties in with my clinical involvement, studying how allograft recipients with HLA antibodies respond to treatments aimed at lowering antibodies, to facilitate transplantation or treat antibody-mediated rejection. I am also interested in better understanding how novel antibody detection methods can better help facilitate transplantation and predict the risk of antibody-mediated rejection.
SpecialtiesHistocompatibility and Immunogenetics, Liver Pathobiology
Selected PublicationsView Dr. Lunz's publications on PubMed
Zeevi A and Lunz J. HLA Antibody profiling in thoracic transplantation undergoing desensitization therapy (In Press) Current Opinion in Organ Transplantation.
Adeyi O, Alexander G, Baiocchi L, Balasubramanian M, Batal I, O C BC, Bhan A, Bridges N, Bucuvalas J, Charlotte F, Colvin B, Czaja A, Demetris A, Devera M, S EM, Feng S, Ferrell L, Fiel Maria I, Fontes P, Fung J, Haga H, Hart J, Honsova E, Hubscher S, Wesam I, Itoh T, Jhala N, Jungmann P, Khettry U, Koshiba T, Lassman C, Lerut J, Ligato S, Lunz J, Mazariegos G, McCaughan G, A MS, I MM, Misdraji J, Mohanakumar T, Molne J, Musat A, Nalesnik M, Nasser I, Neil D, Neuberger J, Pappo O, Petrovic L, Randhawa P, P RF, Rubin E, Ruiz P, Sagol O, Sanchez F, Sasatomi E, Schiano T, Sebagh M, Shaked A, Sharkey Francis E, Shimizu T, Sis B, Smith M, Sonzogni A, Tchao N, Thung S, Tisone G, Tsamandas A, Wernerson A, Wu T, Yilmaz F; The Banff Working Group on Liver Allograft Pathology. Importance of liver biopsy findings in immunosuppression management: Biopsy monitoring and working criteria for patients with operational tolerance (OT). (2012) Liver Transpl. 2012 May 29. doi: 10.1002/lt.23481.
Mizuguchi Y, Specht S, Lunz JG 3rd, Isse K, Corbitt N, Takizawa T, Demetris AJ. Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics. (2012) PLoS One. 2012;7(2):e32449. Epub 2012 Feb 22.
J. Lunz, K. M. Ruppert, M. M. Cajaiba, K. Isse, C. A. Bentlejewski, M. Minervini, M. A. Nalesnika, P. Randhawa, E. Rubin, E. Sasatomi, M. E. de Vera, P. Fontes, A. Humar, A. Zeevi and A. J. Demetris, (2012) Re-examination of the Lymphocytotoxic Crossmatch in Liver Transplantation: Can C4d Stains Help in Monitoring? American Journal of Transplantation, Jan; 12(1):171-82.
Batal I, Azzi J, El-Haddad N, Riella LV, Lunz JG 3rd, Zeevi A, Sasatomi E, Basu A, Tan H, Shapiro R, Randhawa P. (2012) Immunohistochemical markers of tissue injury in biopsies with transplant glomerulitis. Human Pathology,Jan; 43(1) 69-80.
Batal I, Lunz JG 3rd, Aggarwal N, Zeevi A et al (2010) A critical apprasial of methods to grade transplant glomerulitis in renal allograft biopsies. American Journal of Transplantation Nov; 10(11):2442-52.
Isse K, Grama K, Abbott IM, Lesniak A, Lunz JG, Lee WM, Specht S, Corbitt N, Mizuguchi Y, Roysam B, Demetris AJ (2010). Adding value to liver (and allograft) biopsy evaluation using a combination of multiplex quantum dot immunostaining, high-resolution whole-slide digital imaging, and automated image analysis. Clinics in Liver Disease, Nov 2010; 14(4): 669-686.
Batal I, Zeevi A, Lunz JG, Aggarwal N, Shapiro R, Randhawa P, Girnita A. Antihuman Leukocyte Antigen-Specific Antibody Strenght Determined by Complement-Dependent or Solid-Phase Assays Can Predict Positive Donor-Specific Crossmatches. (2010) Archives of Pathology and Laboratory Medicine 2010; 134(10) 1534-40.
Isse K, Specht SM, Lunz JG, 3rd, Kang LI, Mizuguchi Y, Demetris AJ. Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans. (2010) Hepatology 2010; 51 (3): 869.
Shapiro R, Basu A, Zeevi A, Lunz J, Mapara, M, Randhawa, P, Morgan, C, Tan, HP, Sharma, V. Bortezomib rescue in refractory acute humoral rejection--report of a case. (2009) Clinical Transplants 2009: 431.
Zeevi, A., Lunz J.G. 3rd, Shapiro, R., Randhawa, P., Mazariegos, G., Webber, S., Girnita A. (2009). The Emerging Role of Donor-Specific Anti-HLA Antibody Determination for Clinical Management after Solid Organ Transplantation. Human Immunology. 2009 Aug; 70(8):645-650.
Demetris, A.J., Specht, S., Nozaki, I., Lunz, J.G., Beer-Stolz, D., Murase, N. Wu, T. (2008). Small Proline Rich Proteins Function as SH3 Domain Ligands, Increase Resistance to Injury and are Associated with Epithelial-Mesenchymal Transition in Biliary Epithelial Cells. Journal of Hepatology. 2008, Feb; 48(2):276-288.
Lunz, J.G. Specht, S. Murase, N. Isse, K., Demetris, A.J. (2007) Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic IL-6/ STAT3 activity. Hepatology. 2007 Dec; 46(6):1946-1959.
Lunz JG 3rd, Tsuji H, Nozaki I, Murase N, Demetris AJ. (2005) An inhibitor of cyclin-dependent kinase, stress-induced p21Waf-1/Cip-1, mediates hepatocyte mito-inhibition during the evolution of cirrhosis. Hepatology. 2005 Jun;41(6):1262-71.
Lunz JG 3rd, Contrucci S, Ruppert K, Murase N, Fung JJ, Starzl TE, Demetris AJ. (2001). Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs. Am J Pathol. 2001 Apr;158(4):1379-90.