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Research Interests:
Dr. Kuan is a gastrointestinal surgical pathologist. His research interests are centered around 3 main areas (1) regulation and expression of mucin genes in normal, preneoplastic and neoplastic cells and tissue in GI tract; (2) the molecular classification of colorectal and appendiceal cancers and (3) the serrated neoplastic pathway in colorectal cancer including microsatellite instable colon cancer and its precursors (SSA, TSA, mixed polyp).
Selected Publications:
Raval JS, Zeh HJ, Moser AJ, Lee KK, Sander MK, Navina SS, Kuan SF, Krasinskas AM. Pancreatic lymphoepithelial cysts express CEA and can contain mucous cells: potential pitfalls in the preoperative diagnosis. Modern Pathology 2010; 23:1467-76.
Moschos SJ, Jukic DM, Athanassiou C, Bhargava R, Dacic S, Wang X, Kuan SF, Fayewicz SL, Galambos S, Acquatondata M, Dhir R, Becker D. Expression analysis of Ubc9, the single small ubiguitin-like modifier (SUMO) E2 conjugating enzyme, in normal and malignant tissues. Human Pathology 2010; 41:1286-1298.
Bauer S, Parry JA, Muhlenberg T, Brown MF, Seneviratne D, Chatterjee P, Chin A, Rubin BP, Kuan SF, Fletcher JA, Duensing S, Duensing A. Proapoptotic activity of Bortezomib in gastrointestinal stromal tumor cells. Cancer Res 2010; 70:150-159
Qiu W, Carson-Walter EB, Kuan SF, Zhang L, Yu, J. PUMA suppresses intestinal tumorigenesis in mice. Cancer Res 2009; 69(12): 4999-5006
Raab SS, Crzybicki DM, Mahood LK, Parwani AV, Kuan SF, Rao UN. Effectiveness of random and focussed review of review in detecting surgical pathology error. Am J Clin Pathol 2008;130:905-12.
Liu Y, Perdreau SA, Chatterjee P, Wang L, Kuan SF, Duensing A. Imatinib mesylate induces quiescence in gastrointestinal stromal tumor cells through the CDH1-SKP2-p27Kip 1 signaling axis. Cancer Research 2008; 68(21):9015-23.
Owens SR, Chiosea S, Kuan SF. Selective expression of gastric mucin MUC6 in colonic sessile serrated adenoma but not in hyperplastic polyp aids in morphological diagnosis of serrated polyps. Modern Pathology 2008;21:660-9.
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