|
Research Interests:
Dr Kuan's research interests are centering around the expression of various mucin genes in normal and malignant cells. He is also interested in the oncogenic pathways of colon adenoma-carcinoma sequence. His research projects include:
- Regulation of mucin gene expression in normal, preneoplastic and neoplastic cells and tissues.
- Use of mucin genes as markers for cancer progression and prognosis.
- Use of mucin genes as tissue-specific markers for tumor of unknown primary site.
- The chromosomal instability pathway of colon adenoma-carcinoma sequence.
- The microsatellite instability pathway of : colon hyperplastic polyp - serrated adenoma -carcinoma sequence.
Selected Publications:
Hassan A, Yerian LM, Kuan SF, Xiao SY, Hart J, Wang HL. Immunohistochemical evaluation of APC, beta-catenin, c-Myc, cyclin D1, p53 and RB protein expression in syndromic and sporadic fundic gland polyps. Hum Pathol 2004;35:328-334
Ho JJL, Han SW, Pan PL, Deng G, Kuan SF, Kim YS. Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells. Int J Oncol 2003;22:273-9.
Kim GE, Bae H-I, Park H-U, Kuan SF. Crawley SC, Ho JJL, Kim YS. Aberrant expression of MUC 5AC and MUC 6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas. Gastroenterology 2002;123:1052-60.
Kuan SF, Montag AG, Hart J, Krausz T, Recant W. Differential expression of mucin genes in mammary and extramammary Paget’s diseases. Am J Surg Path 2001;25:1469-77.
Te HS, Schiano TD, Kuan SF, Hanauer SB, Conjeevaram HS, Baker AL. Hepatic effects of long-term methotrexate use in the treatment of inflammatory bowel disease. Am J Gastroenterol 2000;95:3150-6.
Goldstein NS, Long A, Kuan SF, Hart J. Colon signet ring cell adenocarcinoma: immunohistochemical characterization and comparison with gastric and typical colon adenocarcinomas. Applied Immuno- histochemistry & Molecular Morphology 2000;8:183-8.
|
