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Research Interests:
Dr. Katyal's research is in the area of pulmonary biology, especially how the lung develops in utero and regenerates after injury. Dr. Katyal's laboratoy in the past has primarily focused on the isolation and characterization of surfactant-associated proteins. His laboratory has isolated and characterized a human gene encoding the major pulmonary surfactant-associated protein, SP-A. Ongoing studies in his laboratory therefore focus on the regulation of human SP-A gene expression. These studies search for biological and therapeutic agents that regulate the production of SP-A in developing lungs. A second project is to identify growth factors that participate in lung development, and in repair process after lung injury. The group is currently investigating the role of a newly discovered growth factor, hepatocyte growth factor (HGF) in these processes.
Selected Publications:
Singh G, Katyal SL. Clara cell proteins. Ann N Y Acad Sci. 2000;923:43-58. Review.
Oshika E, Liu S, Singh G, Michalopoulos GK, Shinozuka H, Katyal SL. Antagonistic effects of dexamethasone and retinoic acid on rat lung morphogenesis. Pediatr Res. 1998 Mar;43(3):315-24.
Oshika E, Liu S, Ung LP, Singh G, Shinozuka H, Michalopoulos GK, Katyal SL. Glucocorticoid-induced effects on pattern formation and epithelial cell differentiation in early embryonic rat lungs. Pediatr Res. 1998 Mar;43(3):305-14.
Emura M, Ochiai A, Singh G, Katyal SL, Hirohashi S. In vitro reconstitution of human respiratory epithelium. In Vitro Cell Dev Biol Anim. 1997 Sep;33(8):602-5
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