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Research Interests:
Dr. Herberman's major research interests are to characterize the effector cells for natural antitumor immunity and explore their role in the development and metastatic spread of cancer. Particular emphasis is directed towards the characterization of natural killer (NK) cells, the regulation of their activity, their in vivo distribution, and the mechanism for their cytotoxic activity. A second area of investigation is the preclinical evaluation of biological response modifiers, in terms of the mechanisms for their immuno-modulatory activities and their therapeutic efficacy against cancer.
Selected Publications:
View Dr. Herberman's publications on PubMed
Gorelik E, Landsittel DP, Marrangoni AM, Modugno F, Velikokhatnaya L, Winans MT, Bigbee WL, Herberman RB, Lokshin AE. Multiplexed immunobead-based cytokine profiling for early detection of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):981-7.
Herberman RB. Translation of scientific insights to benefit patients with cancer. Cancer Biol Ther. 2004 Aug;3(8):778-81.
Herberman RB. Cancer immunotherapy with natural killer cells. Semin Oncol. 2002 Jun;29(3 Suppl 7):27-30. Review.
Basse PH, Whiteside TL, Herberman RB. Cancer immunotherapy with interleukin-2-activated natural killer cells. Mol Biotechnol. 2002 Jun;21(2):161-70.
Basse PH, Whiteside TL, Chambers W, Herberman RB. Therapeutic activity of NK cells against tumors. Int Rev Immunol. 2001 Jun;20(3-4):439-501. Review.
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