Jie Han, PhD
Dr. Han is a member of the University of Pittsburgh Cancer Institute.
Hillman Cancer Center
5117 Centre Avenue
Pittsburgh, PA 15213-1863
Office Telephone: 412-623-1410
Research ExpertiseI plan to study the ability of p53 transcriptional mutants to induce Bim dependent apoptosis. This information is needed for a new submission of a manuscript on regulation of p53 by Mcl-1.
In addition, I plan to continue to work ona new TRAIL-mediated autophagic model that we recently developed. At the same time I'll try to get data on cross-regulation of apoptosis and autophagy, so that I'll be able to submit an ACS application next year.
Selected PublicationsView Dr. Han's publications on PubMed
Hou W, Han J, Lu C, Goldstein LA, Rabinowich H. Autophagic degradation of active caspase-8: a crosstalk mechanism between autophagy and apoptosis. Autophagy. 2010; 6:891-900.
Han J, Goldstein LA, Hou W, Gastman BR, Rabinowich H. Regulation of mitochondrial apoptotic events by p53-mediated disruption of complexes between antiapoptotic Bcl-2 members and Bim. J Biol Chem. 2010; 285:22473-22483.
Han J, Goldstein LA, Hou W, Froelich CJ, Watkins SC, Rabinowich H. Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage. J Biol Chem. 2010; 285:22461-22472.
Czystowska M, Han J, Szczepanski MJ, Szajnik M, Quadrini K, Brandwein H, Hadden JW, Signorelli K, Whiteside TL. IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death. Cell Death Differ. 2009; 16:708-718.