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Dr. Han is a member of the Division of Transplantation Pathology. More information about this division is available here.
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Office Location:
Biomedical Science Tower, E1514
200 Lothrop Street
Pittsburgh, PA 15213
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Contact Information:
Phone: (412) 648-1474
Fax: (412) 647-5237
E-mail: hanc@upmc.edu
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Research Interests:
Dr. Han's research is focused on understanding the role of prostaglandins and related signaling pathways in the pathogenesis of hepatobiliary carcinogenesis.
Selected Publications:
- Han C, Demetris AJ, Stolz DB, Xu LH, Lim K, and Wu T. Modulation of STAT3 activation by the cPLA2alpha and COX2 controlled PGE2 signaling pathway. J. Biol. Chem. 2006, 281(34): 24831-24846.
- Han C, Michalopoulos G and Wu T. Cross-talk between the COX-2-controlled PGE2/EP1 and the EGFR and Met signaling pathways in human hepatocellular carcinoma cell invasion. Journal of Cell Physiol. 2006, 207(1): 261-270.
- Han C and Wu T. Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt. J. Biol. Chem. 2005, 280 (25):24053-24063.
- Han C, Demetris AJ, Liu Y, Shelhamer JH and Wu T. TGF-beta activates cPLA2 alpha -mediated PGE2/EP1 and PPAR-gamma/Smad signaling pathways in human liver cancer cells: a novel mechanism for subversion of TGF-beta-induced mitoinhibition. J. Biol. Chem. 2004, 279 (43):44344-44354.
- Han C, Leng J, Demetris AJ, and Wu T. Cyclooxygenase-2 promotes human cholangiocarcinoma cell growth: evidence for cyclooxygenase-2 independent mechanism in celecoxib-mediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest. Cancer Res. 2004, 64:1369-1376.
- Wu T, Han C, Shelhamer JH. Involvement of p38 and p42/44 MAP kinases and protein kinase C in the interferon-gamma and interleukin-1alpha-induced phosphorylation of 85-kDa cytosolic phospholipase A2 in primary human bronchial epithelial cells. Cytokine 2004, 25(1):11-20.
- Leng J, Han C, Demetris AJ, Michalopoulos GK, and Wu T. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. Hepatology 2003, 38:756-768.
- Han C, Demetris, AJ, Michalopoulos GK, Zhan Q, Shelhamer JH, and Wu T. PPARgamma ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21WAF/Cip1 pathway. Hepatology 2003, 38:167-177
- Pawliczak R, Han C, Huang XL, Demetris AJ, Shelhamer JH and Wu T. 85-kDa cytosolic phospholipase A2 mediates peroxisome proliferator-activated receptor-gamma activation in human lung epithelial cells. J. Biol. Chem. 2002, 277(36):33153-33163.
- Wu T, Han C, Lunz JG, Michalopoulos G, Shelhamer JH, and Demetris AJ. Involvement of 85-kd cytosolic phospholipase A2 and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells. Hepatology 2002, 36:363-373.
- Han C, Demetris AJ, Michalopoulos G, Shelhamer JH and Wu T. 85-kDa Cytosolic phospholipase A2 plays a critical role in PPAR-mediated gene transcription in human hepatoma cells. Am. J. Physiol. (GI Liver Physiol). 2002, 282(4):G586-597
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