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Research Interests:
Dr. Frye's research interest is looking into whether SIRT1 overexpression might play a role in prostate carcinoma. The lab of Dr. Reinberg at HHMI Rutgers recently reported that SIRT1 acts in a complex with Ezh2 within cancer cells, previous work has implicated Ezh2 in prostate carcinogenesis. Some of this work is being done in collaboration with Dr. Jian Zhang a prostate cancer researcher who recently joined the Pittsburgh VA Medical Center
Selected Publications:
Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 2004 Jun 16;23(12):2369-80.
van der Horst A, Tertoolen LG, de Vries-Smits LM, Frye RA, Medema RH, Burgering BM. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem. 2004 Jul 9;279(28):28873-9.
O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, Espinosa R, LeBeau MM, Earp SH and Liu ET. Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Bio 11:5016-5031, 1991.
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