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Research Interests:
Dr. Felgar's research interests relate to the classification and pathobiology of hematopoietic and lymphoid malignancies and the application of normal immunobiology as it may relate to hematopoietic tumors, with a particular interest in T and NK cell malignancy and myelodysplasia. He has expertise in both flow cytometry and immunohistochemistry.
Selected Publications:
Huggins J, Pellegrin T, Felgar RE, Wei C, Brown M, Zheng B, Milner EC, Bernstein SH, Sanz I, Zand MS. CpG DNA activation and plasma cell differentiation of CD27- na?ve human B cells. 2007. Blood 109:1611-1619.
Ryan EP, Pollock SJ, Kaur K, Felgar RE, Bernstein SH, Chiorrazi N, Phipps R. Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells. 2006. Clinical Immunology, 120:76-90.
Winter JN. Weller EA, Horning, SJ, Krajewska M, Variakojis D, Habermann TM, Fisher RI, Kurtin PJ, Macon WR, Chhanabhai M, Felgar RE, Hsi ED, Medeiros LJ, Weick JK, Reed JC, Gascoyne RD. Prognostic significance of bcl-6 protein expression in DLBCL treated with CHOP or R-CHOP: a prospective correlative study. 2006. Blood, 107:4207-4213.
Zand MS, Vo T, Pellegrin T, Felgar R, Liesveld JL, Ifthikharuddin JJ, Abboud CN, Sanz I, Huggins J. Apoptosis and complement mediated lysis of myeloma cells by polyclonal rabbit anti-thymocyte globulin. 2005. Blood, 107:2895-28903.
Vargas RL, Fallone E, Felgar RE, Friedberg JW, Arbini AA, Andersen AA, Rothberg PG. Is there an association between ocular adnexal lymphoma and infection with Chlamydia psittaci? The University of Rochester experience. 2005. Leukemia Research, 30:547-551.
Felgar RE, Salhany KE, Macon WR, Pietra GG, and Kinney MC. The expression of TIA-1+ cytolytic type granules and other cytolytic lymphocyte-associated markers in CD30+ anaplastic large cell lymphomas (ALCL): Correlation with morphology, immunophenotype, ultrastructure, and clinical features. Human Pathology 30:228-236, 1999.
Salhany KE, Macon WR, Choi JK, Elenitsas R, Lessin SR, Felgar RE, Wilson DM, Przybylski GK, Lister J, Wasik MA, and Swerdlow SH. Subcutaneous panniculitis-like T-cell lymphoma: Clinicopathologic, immunophenotypic, and genotypic analysis of and subtypes. American Journal of Surgical Pathology 22:881-893, 1998.
Felgar RE, Macon WR, Kinney MC, Roberts S, Pasha T, and Salhany KE. TIA-1 expression in lymphoid neoplasms: Identification of subsets with cytotoxic T lymphocyte or natural killer cell differentiation. American Journal of Pathology 150:1893-1900, 1997.
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