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Research Interests:
Dr. Ding's research focuses on the regulation of autophagy, apoptosis and necrosis in liver injury. He is also interested in investigating the role of autophagy in the cancer cells and its potential application in cancer therapy via inhibition of autophagy.
Selected Publications:
Ding, W.X, Ni, H.M., Defrancesca, D., Stolz, D.B., and Yin, X.M (2004) Bid-Induced Oxygen Radicals Promote Mitochondrial Dysfunction, Caspase Activation and Hepatocyte Apoptosis. HEPATOLOGY 40:403-413.
Chen X, Ding, W.X. Ni, H.M., Gao, W., Shi, Y.H., Gambotto, A.A., Fan, J., Beg, A.A. and Yin, X.M. (2007) Bid-independent Mitochondria Activation in TNF{alpha}-induced Apoptosis and Liver Injury. Mol Cell Biol. 27(2):541-53.
Ding, W.X. Ni, H.M., Gao, W., Hou, Y.F., Melan, M.A., Chen X, Stolz, D.B., Shao, Z.M., and Yin, X.M. (2007) Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J Biol Chem. 282(7):4702-10.
Ding, W.X., Ni, H.M, Chen, X., Yu, J., Zhang, L., and Yin, X.M. (2007) A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells. Mol Cancer Ther. 6(3):1062-9. * Cover story.
Ding, W.X. Ni, H.M., Gao, W., Yoshimori, T., Stolz, D.B., Ron, D., and Yin, X.M. (2007) Linking of Autophagy to Ubiquitin-Proteasome System Is Important for the Regulation of Endoplasmic Reticulum Stress and Cell Viability. Am J Pathol. 171(2):513-24.
Ding, W.X*. Ni, H.M.,and Yin, X.M. (2007) Absence of bax switched MG132-induced apoptosis to non-apoptotic cell death that is suppressed by transcriptional and translational inhibitors. Apoptosis. * correspondence author.
Ding, W.X., and Yin, X.M. Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome. Autophagy. 2007 Oct 19;4(2) [Epub ahead of print].
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