Anthony J. Demetris, MD
Starzl Professor of Liver and Transplant Pathology


Dr. Demetris is the Director of the Division of Transplantation Pathology.

Office Location:
Division of Transplantation Pathology
Department of Pathology
UPMC-Montefiore, Room E-741
3459 5th Avenue
Pittsburgh, PA 15213

Contact Information:
Office Telephone: 412-647-2072
Lab Telephone: 412-624-6605
Fax: 412-647-2084
Email: demetrisaj@upmc.edu

Education

  • BS - 1978, Rensselaer Polytechnic Institute
  • MD - 1982, University of Pittsburgh

Clinical Expertise

  • Native and allograft liver, kidney, and heart pathology
  • Autoimune and inflammatory disorders, liver and biliary tract cancers

Research Interests

Dr. Demetris' interests include:
  • the immunobiology of tolerance induction and chronic rejection
  • the role of cytokines in growth control of biliary epithelium
  • digital pathology for enhancing transplantation pathology and research
Current translational and basic research projects include:
  • study and development of experimental animal and human protocols to understand mechanisms of spontaneous operational tolerance to solid organ allografts
  • the role of IL-6 in biliary epithelial cell biology and chronic liver disease
  • use of multiplexing and high resolution whole slide imaging in studying biological phenomena, including tolerance induction and biliary pathobiology

Certifications

  • Medical License - Commonwealth of Pennsylvania, Department of State, Bureau of Professional and Occupational Affairs - 1984
  • The American Board of Pathology, Combined Anatomical and Clinical Pathology - 1987

Awards and Honors

  • International Liver Transplantation Society, Distinguished Service Award 2012
  • PEW Scholar Program Candidate, University of Pittsburgh 1987
  • Resident Research Award, Pittsburgh Academy of Medicine 1984, 1985
  • Alpha Omega Alpha (Medical Honor Society) 1982

Selected Publications

View Dr.Demetris' publications on PubMed

Demetris AJ, Lunz, III JG, Randhawa P, Wu T, Nalesnik M, Thomson AW: Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective. Transpl Int. Jan 1;22(1Special Review Issue: Minimization of Immunosuppression):120-141, 2009.

Abu-Elmagd KM, Costa G, Bond GJ, Wu T, Murase N, Zeevi A, Simmons R, Soltys K, Sindhi R, Stein W, Demetris A, Mazariegos G: Evolution of the immunosuppressive strategies for the intestinal and multivisceral recipients with special reference to allograft immunity and achievement of partial tolerance. Transpl Int. Jan 1;22(1Special Review Issue: Minimization of Immunosuppression):96-109, 2009.

Ashokkumar C, Talukdar A, Sun Q, Higgs BW, Janosky J, Wilson P, Mazariegos G, Jaffe R, Demetris A, Dobberstein J, Soltys K, Bond G, Thomson AW, Zeevi A, Sindhi R: Allospecific CD154+ T Cells Associate with Rejection Risk After Pediatric Liver Transplantation. Am J Transplant. Jan;9(1):179-91, 2009.

Minervini MI, Ruppert K, Fontes P, Volpes R, Vizzini G, de Vera ME, Gruttadauria S, Miraglia R, Pipitone L, Marsh JW, Marcos A, Gridelli B, Demetris AJ: Liver biopsy findings from healthy potential living liver donors: Reasons for disqualification, silent diseases and correlation with liver injury tests. J Hepatol. Mar;50(3):501-10, 2009.

de Vera ME, Lopez-Solis R, Dvorchik I, Campos S, Morris W, Demetris AJ, Fontes P, Marsh JW: Liver transplantation using donation after cardiac death donors: long-term follow-up from a single center. Am J Transplant. Apr;9(4):773-81, 2009.

Sumpter TL, Lunz Iii JG, Castellaneta A, Matta B, Tokita D, Turnquist HR, Mazariegos GV, Demetris AJ, Thomson AW: Dendritic cell immunobiology in relation to liver transplant outcome. Front Biosci (Elite Ed). Jun 1;1:99-114, 2009.

Isse K, Specht SM, Lunz JG 3rd, Kang LI, Mizuguchi Y, Demetris AJ: Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans. Hepatology. Mar;51(3):869-80, 2010.

Kelly DM, Zhu X, Shiba H, Irefin S, Trenti L, Cocieru A, Diago T, Wang LF, Quintini C, Chen Z, Alster J, Nakagawa S, Miller C, Demetris A, Fung JJ: Adenosine restores the hepatic artery buffer response and improves survival in a porcine model of small-for-size syndrome. Liver Transpl. Nov;15(11):1448-57, 2009.

Demetris AJ: Evolution of hepatitis C virus in liver allografts. Liver Transpl. Nov;15 Suppl 2:S35-41, 2009.

Toso C, Isse K, Demetris AJ, Dinyari P, Koh A, Imes S, Kin T, Emamaullee J, Senior P, Shapiro AM: Histologic graft assessment after clinical islet transplantation. Transplantation. Dec 15;88(11):1286-93, 2009.

Sis B, Mengel M, Haas M, Colvin RB, Halloran PF, Racusen LC, Solez K, Baldwin WM 3rd, Bracamonte ER, Broecker V, Cosio F, Demetris AJ, Drachenberg C, Einecke G, Gloor J, Glotz D, Kraus E, Legendre C, Liapis H, Mannon RB, Nankivell BJ, Nickeleit V, Papadimitriou JC, Randhawa P, Regele H, Renaudin K, Rodriguez ER, Seron D, Seshan S, Suthanthiran M, Wasowska BA, Zachary A, Zeevi A: Banff '09 Meeting Report: Antibody Mediated Graft Deterioration and Implementation of Banff Working Groups. Am J Transplant. Mar;10(3):464-71, 2010.

Mavrakis A, Demetris A, Ochoa ER, Rabinovitz M: Hereditary Hemorrhagic Telangiectasia of the Liver Complicated by Ischemic Bile Duct Necrosis and Sepsis: Case Report and Review of the Literature. Dig Dis Sci. Jul;55(7):2113-7, 2010 Review

Matte-Martone C, Wang X, Anderson B, Jain D, Demetris AJ, McNiff J, Shlomchik MJ, Shlomchik WD: Recipient B Cells Are Not Required For GVHD Induction. Biol Blood Marrow Transplant. Sep;16(9):1222-1230, 2010.

Zecher D, Li Q, Oberbarnscheidt MH, Demetris AJ, Shlomchik WD, Rothstein DM, Lakkis FG: NK Cells Delay Allograft Rejection in Lymphopenic Hosts by Downregulating the Homeostatic Proliferation of CD8+ T Cells. J Immunol. Jun 15;184(12):6649-57, 2010.

Han C, Bowen WC, Li G, Demetris AJ, Michalopoulos GK, Wu T: Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transformed hepatocyte growth. Hepatology. Aug;52(2):644-55, 2010.

Sasaki K, Parwani AV, Demetris AJ, Sasatomi E: Heterotopic breast epithelial inclusion of the heart: report of a case. Am J Surg Pathol. Oct;34(10):1555-9, 2010.

Li H, Kaplan DH, Matte-Martone C, Tan HS, Venkatesan S, Johnson K, Demetris A, McNiff J, Shlomchik M, Shlomchik WD: Langerhans cells are not required for graft-versus-host disease. Blood. Jan 13:117(2)697-707, 2011.

Isse K, Grama K, Abbott IM, Lesniak A, Lunz JG, Lee WM, Specht S, Corbitt N, Mizuguchi Y, Roysam B, Demetris AJ: Adding Value to Liver (and Allograft) Biopsy Evaluation Using a Combination of Multiplex Quantum Dot Immunostaining, High-Resolution Whole-Slide Digital Imaging, and Automated Image Analysis.Clin Liver Dis.Nov;14(4):669-85, 2010.

Li H, Matte-Martone C, Tan HS, Venkatesan S, McNiff J, Demetris AJ, Jain D, Lakkis F, Rothstein D, Shlomchik WD: Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells. J Immunol. 2011 Jan 1;186(1):230-41.

Martin T, Schwartz J, Demetris A, Comstock J, Lowichik A, Book L: Plasmapheresis treatment of antibody-mediated rejection in an A2 donor to O pediatric liver transplant recipient. Pediatr Transplant. 2011 Feb;15(1):E15-8. doi: 10.1111/j.1399-3046.2009.01224.x.

Oberbarnscheidt MH, Walch JM, Li Q, Williams AL, Walters JT, Hoffman RA, Demetris AJ, Gerard C, Camirand G, Lakkis FG: Memory T Cells Migrate to and Reject Vascularized Cardiac Allografts Independent of the Chemokine Receptor CXCR3. Transplantation. Apr 27;91(8):827-32, 2011.

Ueki S, Castellaneta A, Yoshida O, Ozaki K, Zhang M, Kimura S, Isse K, Ross M, Shao L, Stolz DB, Thomson AW, Demetris AJ, Geller DA, Murase N: Hepatic B7-H1 expression is essential to control cold ischemia/reperfusion injury after mouse liver transplantation. Hepatology. Jul;54(1):216-28, 2011. doi: 10.1002/hep.24360.

Anderson BE, Tang AL, Wang Y, Froicu M, Rothstein D, McNiff JM, Demetris AJ, Farber DL, Shlomchik WD, Shlomchik MJ: Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4 effector memory T cells. Eur J Immunol. 2011 Sep;41(9):2782-92.

Thomson AW, Geller DA, Gandhi C, Murase N, Demetris AJ, Beer-Stolz D: Hepatic antigen-presenting cells and regulation of liver transplant outcome. Immunol Res. Aug;50(2-3):221-7, 2011.

Juchem KW, Anderson BE, Zhang C, McNiff JM, Demetris AJ, Farber DL, Caton AJ, Shlomchik WD, Shlomchik MJ: A repertoire-independent and cell intrinsic defect in murine GVHD induction by effector memory T cells. Blood. 2011 Jul 18. [Epub ahead of print]

Camirand G, Li Q, Demetris AJ, Watkins SC, Shlomchik WD, Rothstein DM, Lakkis FG: Multiphoton intravital microscopy of the transplanted mouse kidney. Am J Transplant. 2011 Oct;11(10):2067-74. doi: 10.1111/j.1600-6143.2011.03671.x. Epub 2011 Aug 11.

Li N, Matte-Martone C, Zheng H, Cui W, Venkatesan S, Tan HS, McNiff J, Demetris AJ, Roopenian D, Kaech S, Shlomchik WD: Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improves GVL and immune reconstitution. Blood. 2011 Nov 24;118(22):5965-76.

Turnquist HR, Zhao Z, Rosborough BR, Liu Q, Castellaneta A, Isse K, Wang Z, Lang M, Beer Stolz D, Zheng XX, Demetris AJ, Liew FY, Wood KJ, Thomson AW: IL-33 Expands Suppressive CD11b+ Gr-1int and Regulatory T Cells, including ST2L+ Foxp3+ Cells, and Mediates Regulatory T Cell-Dependent Promotion of Cardiac Allograft Survival. J Immunol. 2011 Nov 1;187(9):4598-610.

Lunz JG, Ruppert K, Cajaiba M, Isse K, Bentlejewski C, Minervini M, Nalesnik M, Randhawa P, Rubin E, Sasatomi E, DeVera M, Fontes P, Humar A, Zeevi A, Demetris A. Re-examination of the Lymphocytotoxic Crossmatch in Liver Transplantation: Can C4d Stains Help in Monitoring? Am J Transplant. 2012 Jan;12(1):171-82.

Nakanuma Y, Demetris AJ, Ueno Y, Quaglia A: Cholangiopathy: genetics, mechanism, and pathology. Int J Hepatol. 2012;2012:950713. Epub 2011 Sep 18.

Gorantla VS, Demetris AJ: Acute and chronic rejection in upper extremity transplantation: what have we learned? Hand Clin. 2011 Nov;27(4):481-93.

Isse K, Lesniak A, Grama K, Roysam B, Minervini MI, Demetris AJ. Digital Transplantation Pathology: Combining Whole Slide Imaging, Multiplex Staining, and Automated Image Analysis. Am J Transplant. 2012 Jan;12(1):27-37. doi: 10.1111/j.1600-6143.2011.03797.x

Zhu X, Shiba H, Fung JJ, Wang LF, Arakawa Y, Irefin S, Demetris AJ, Kelly DM: The Role of the A2a Receptor Agonist, Regadenoson, in Modulating Hepatic Artery Flow in the Porcine Small-for-Size Liver Graft. J Surg Res. 2011 Oct 27.

Zecher D, Li Q, Williams AL, Walters JT, Baddoura FK, Chalasani G, Rothstein DM, Shlomchik WD, Demetris AJ, Lakkis FG: Innate immunity alone is not sufficient for chronic rejection but predisposes healed allografts to T cell-mediated pathology. Transpl Immunol. 2012 Mar;26(2-3):113-8.

Feng S, Ekong UD, Lobritto SJ, Demetris AJ, Roberts JP, Rosenthal P, Alonso EM, Philogene MC, Ikle D, Poole KM, Bridges ND, Turka LA and Tchao NK: Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants. JAMA. 2012 Jan 18;307(3):283-93.

Mengel M, Sis B, Haas M, Colvin RB, Halloran PF, Racusen LC, Solez K, Cendales L, Demetris AJ, Drachenberg CB, Farver CF, Rodriguez ER, Wallace WD, Glotz D; as the Banff meeting report writing committee: Banff 2011 Meeting Report: New Concepts in Antibody-Mediated Rejection. Am J Transplant. 2012 Feb 2. doi: 10.1111/j.1600-6143.2011.03926.x.

Macedo C, Walters JT, Orkis EA, Isse K, Elinoff BD, Fedorek SP, McMichael JM, Chalasani G, Randhawa P, Demetris AJ, Zeevi A, Tan H, Shapiro R, Landsittel D, Lakkis FG, Metes D: Long-Term Effects of Alemtuzumab on Regulatory and Memory T-Cell Subsets in Kidney Transplantation. ransplantation. 2012 Feb 17.

Mizuguchi, Y, Specht, S, Lunz, J, Isse, K, Corbitt, N, Takizawa, T, Demetris, AJ. Cooperation of p300 and PCAF in the control of microRNA 200c/141 transcription and epithelial characteristics. PLOS One 2012;7(2):e32449. Epub 2012 Feb 22

Li H, Demetris AJ, McNiff J, Matte-Martone C, Tan HS, Rothstein DM, Lakkis FG, Shlomchik WD: Profound Depletion of Host Conventional Dendritic Cells, Plasmacytoid Dendritic Cells, and B Cells Does Not Prevent Graft-versus-Host Disease Induction. J Immunol. 2012 Apr 15;188(8):3804-11.