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Research Interests:
Dr. Demetris' interests include the: 1) immunobiology of tolerance induction and chronic rejection; 2) the role of cytokines in growth control of biliary epithelium; and 3) digital pathology for enhancing transplantation pathology and research. Current translational and basic research projects include: a) study and development of experimental animal and human protocols to understand mechanisms of spontaneous operational tolerance to solid organ allografts; b) the role of IL-6 in biliary epithelial cell biology and chronic liver disease; and c) use of multiplexing and high resolution whole slide imaging in studying biological phenomena, including tolerance induction and biliary pathobiology.
Selected Publications:
View Dr.Demetris' publications on PubMed
Lim K, Han C, Xu L, Isse K, Demetris AJ, Wu T.Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids. Cancer Res. Jan 15;68(2):553-60, 2008.
Demetris AJ, Specht S, Nozaki I, Lunz JG 3rd, Stolz DB, Murase N, Wu T: Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes.J Hepatol. Feb;48(2):276-288, 2008.
Anderson BE, Taylor PA, McNiff JM, Jain D, Demetris AJ, Panoskaltsis-Mortari A, Ager A, Blazar BR, Shlomchik WD, Shlomchik MJ: Effects of donor T cell trafficking and priming site on GVHD induction by naive and memory phenotype CD4 T cells. Blood. 2008 May 15;111(10):5242-51. Epub 2008 Feb 19.
Toyokawa H, Nakao A, Bailey RJ, Nalesnik MA, Kaizu T, Lemoine JL, Ikeda A, Tomiyama K, Papworth GD, Huang L, Demetris AJ, Starzl TE, Murase N:Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation. Liver Transpl. Mar;14(3):346-57, 2008.
Adeyi OA, Randhawa PA, Nalesnik MA, Ochoa ER, Abu-Elmagd KM, Demetris AJ, Wu T: Posttransplant adenoviral enteropathy in patients with small bowel transplantation. Arch Pathol Lab Med. Apr;132(4):703-5, 2008.
Krasinskas AM, Demetris AJ, Poterucha JJ, Abraham SC: The prevalence and natural history of untreated isolated central perivenulitis in adult allograft livers. Liver Transpl. May;14(5):625-32, 2008.
Drachenberg CB, Odorico J, Demetris AJ, Arend L, Bajema IM, Bruijn JA, Cantarovich D, Cathro HP, Chapman J, Dimosthenous K, Fyfe-Kirschner B, Gaber L, Gaber O, Goldberg J, Honsová E, Iskandar SS, Klassen DK, Nankivell B, Papadimitriou JC, Racusen LC, Randhawa P, Reinholt FP, Renaudin K, Revelo PP, Ruiz P, Torrealba JR, Vazquez-Martul E, Voska L, Stratta R, Bartlett ST, Sutherland DE: Banff Schema for Grading Pancreas Allograft Rejection: Working Proposal by a Multi-Disciplinary International Consensus Panel. Am J Transplant. Jun;8(6):1237-49, 2008.
Abraham SC, Poterucha JJ, Rosen CB, Demetris AJ, Krasinskas AM: Histologic Abnormalities are Common in Protocol Liver Allograft Biopsies From Patients With Normal Liver Function Tests. Am J Surg Pathol. 2008 Jul;32(7):965-73.
Demetris AJ, Sebagh M: Plasma cell hepatitis in liver allografts: Variant of rejection or autoimmune hepatitis? Liver Transpl. Jun;14(6):750-5, 2008.
Limaye PB, Alarcón G, Walls AL, Nalesnik MA, Michalopoulos GK, Demetris AJ, Ochoa ER: Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development. Lab Invest. Aug;88(8):865-72, 2008.
Balan V, Ruppert K, Demetris AJ, Ledneva T, Duquesnoy RJ, Detre KM, Wei YL, Rakela J, Schafer DF, Roberts JP, Everhart JE, Wiesner RH: Long-term outcome of human leukocyte antigen mismatching in liver transplantation: results of the National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database.Hepatology.Sep;48(3):878-88, 2008.
Demetris AJ, Lunz, III JG, Randhawa P, Wu T, Nalesnik M, Thomson AW: Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective. Transpl Int. Jan 1;22(1Special Review Issue: Minimization of Immunosuppression):120-141, 2009.
Abu-Elmagd KM, Costa G, Bond GJ, Wu T, Murase N, Zeevi A, Simmons R, Soltys K, Sindhi R, Stein W, Demetris A, Mazariegos G: Evolution of the immunosuppressive strategies for the intestinal and multivisceral recipients with special reference to allograft immunity and achievement of partial tolerance. Transpl Int. Jan 1;22(1Special Review Issue: Minimization of Immunosuppression):96-109, 2009.
Ashokkumar C, Talukdar A, Sun Q, Higgs BW, Janosky J, Wilson P, Mazariegos G, Jaffe R, Demetris A, Dobberstein J, Soltys K, Bond G, Thomson AW, Zeevi A, Sindhi R: Allospecific CD154+ T Cells Associate with Rejection Risk After Pediatric Liver Transplantation. Am J Transplant. Jan;9(1):179-91, 2009.
Minervini MI, Ruppert K, Fontes P, Volpes R, Vizzini G, de Vera ME, Gruttadauria S, Miraglia R, Pipitone L, Marsh JW, Marcos A, Gridelli B, Demetris AJ: Liver biopsy findings from healthy potential living liver donors: Reasons for disqualification, silent diseases and correlation with liver injury tests. J Hepatol. Mar;50(3):501-10, 2009.
de Vera ME, Lopez-Solis R, Dvorchik I, Campos S, Morris W, Demetris AJ, Fontes P, Marsh JW: Liver transplantation using donation after cardiac death donors: long-term follow-up from a single center. Am J Transplant. Apr;9(4):773-81, 2009.
Sumpter TL, Lunz Iii JG, Castellaneta A, Matta B, Tokita D, Turnquist HR, Mazariegos GV, Demetris AJ, Thomson AW: Dendritic cell immunobiology in relation to liver transplant outcome. Front Biosci (Elite Ed). Jun 1;1:99-114, 2009.
Isse K, Specht SM, Lunz JG 3rd, Kang LI, Mizuguchi Y, Demetris AJ: Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans. Hepatology. Mar;51(3):869-80, 2010.
Kelly DM, Zhu X, Shiba H, Irefin S, Trenti L, Cocieru A, Diago T, Wang LF, Quintini C, Chen Z, Alster J, Nakagawa S, Miller C, Demetris A, Fung JJ: Adenosine restores the hepatic artery buffer response and improves survival in a porcine model of small-for-size syndrome. Liver Transpl. Nov;15(11):1448-57, 2009.
Demetris AJ: Evolution of hepatitis C virus in liver allografts. Liver Transpl. Nov;15 Suppl 2:S35-41, 2009.
Toso C, Isse K, Demetris AJ, Dinyari P, Koh A, Imes S, Kin T, Emamaullee J, Senior P, Shapiro AM: Histologic graft assessment after clinical islet transplantation. Transplantation. Dec 15;88(11):1286-93, 2009.
Sis B, Mengel M, Haas M, Colvin RB, Halloran PF, Racusen LC, Solez K, Baldwin WM 3rd, Bracamonte ER, Broecker V, Cosio F, Demetris AJ, Drachenberg C, Einecke G, Gloor J, Glotz D, Kraus E, Legendre C, Liapis H, Mannon RB, Nankivell BJ, Nickeleit V, Papadimitriou JC, Randhawa P, Regele H, Renaudin K, Rodriguez ER, Seron D, Seshan S, Suthanthiran M, Wasowska BA, Zachary A, Zeevi: A.Banff '09 Meeting Report: Antibody Mediated Graft Deterioration and Implementation of Banff Working Groups. Am J Transplant. Mar;10(3):464-71, 2010.
Mavrakis A, Demetris A, Ochoa ER, Rabinovitz M: Hereditary Hemorrhagic Telangiectasia of the Liver Complicated by Ischemic Bile Duct Necrosis and Sepsis: Case Report and Review of the Literature. Dig Dis Sci. Jul;55(7):2113-7, 2010 Review
Matte-Martone C, Wang X, Anderson B, Jain D, Demetris AJ, McNiff J, Shlomchik MJ, Shlomchik WD: Recipient B Cells Are Not Required For GVHD Induction. Biol Blood Marrow Transplant. Sep;16(9):1222-1230, 2010.
Zecher D, Li Q, Oberbarnscheidt MH, Demetris AJ, Shlomchik WD, Rothstein DM, Lakkis FG: NK Cells Delay Allograft Rejection in Lymphopenic Hosts by Downregulating the Homeostatic Proliferation of CD8+ T Cells. J Immunol. Jun 15;184(12):6649-57, 2010.
Han C, Bowen WC, Li G, Demetris AJ, Michalopoulos GK, Wu T: Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transformed hepatocyte growth. Hepatology. Aug;52(2):644-55, 2010.
Sasaki K, Parwani AV, Demetris AJ, Sasatomi E: Heterotopic breast epithelial inclusion of the heart: report of a case. Am J Surg Pathol. Oct;34(10):1555-9, 2010.
Li H, Kaplan DH, Matte-Martone C, Tan HS, Venkatesan S, Johnson K, Demetris A, McNiff J, Shlomchik M, Shlomchik WD: Langerhans cells are not required for graft-versus-host disease. Blood. Jan 13:117(2)697-707, 2011.
Isse K, Grama K, Abbott IM, Lesniak A, Lunz JG, Lee WM, Specht S, Corbitt N, Mizuguchi Y, Roysam B, Demetris AJ: Adding Value to Liver (and Allograft) Biopsy Evaluation Using a Combination of Multiplex Quantum Dot Immunostaining, High-Resolution Whole-Slide Digital Imaging, and Automated Image Analysis.Clin Liver Dis.Nov;14(4):669-85, 2010.
Li H, Matte-Martone C, Tan HS, Venkatesan S, McNiff J, Demetris AJ, Jain D, Lakkis F, Rothstein D, Shlomchik WD: Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells. J Immunol. 2011 Jan 1;186(1):230-41.
Martin T, Schwartz J, Demetris A, Comstock J, Lowichik A, Book L: Plasmapheresis treatment of antibody-mediated rejection in an A2 donor to O pediatric liver transplant recipient. Pediatr Transplant. 2011 Feb;15(1):E15-8. doi: 10.1111/j.1399-3046.2009.01224.x.
Oberbarnscheidt MH, Walch JM, Li Q, Williams AL, Walters JT, Hoffman RA, Demetris AJ, Gerard C, Camirand G, Lakkis FG: Memory T Cells Migrate to and Reject Vascularized Cardiac Allografts Independent of the Chemokine Receptor CXCR3. Transplantation. Apr 27;91(8):827-32, 2011.
Ueki S, Castellaneta A, Yoshida O, Ozaki K, Zhang M, Kimura S, Isse K, Ross M, Shao L, Stolz DB, Thomson AW, Demetris AJ, Geller DA, Murase N: Hepatic B7-H1 expression is essential to control cold ischemia/reperfusion injury after mouse liver transplantation. Hepatology. Jul;54(1):216-28, 2011. doi: 10.1002/hep.24360.
Anderson BE, Tang AL, Wang Y, Froicu M, Rothstein D, McNiff JM, Demetris AJ, Farber DL, Shlomchik WD, Shlomchik MJ: Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4 effector memory T cells. Eur J Immunol. 2011 Jun 10. doi: 10.1002/eji.201141678. [Epub ahead of print]
Thomson AW, Geller DA, Gandhi C, Murase N, Demetris AJ, Beer-Stolz D: Hepatic antigen-presenting cells and regulation of liver transplant outcome. Immunol Res. Aug;50(2-3):221-7, 2011.
Juchem KW, Anderson BE, Zhang C, McNiff JM, Demetris AJ, Farber DL, Caton AJ, Shlomchik WD, Shlomchik MJ: A repertoire-independent and cell intrinsic defect in murine GVHD induction by effector memory T cells. Blood. 2011 Jul 18. [Epub ahead of print]
Camirand G, Li Q, Demetris AJ, Watkins SC, Shlomchik WD, Rothstein DM, Lakkis FG: Multiphoton intravital microscopy of the transplanted mouse kidney. Am J Transplant. 2011 Oct;11(10):2067-74. doi: 10.1111/j.1600-6143.2011.03671.x. Epub 2011 Aug 11.
Li N, Matte-Martone C, Zheng H, Cui W, Venkatesan S, Tan HS, McNiff J, Demetris AJ, Roopenian D, Kaech S, Shlomchik WD: Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improves GVL and immune reconstitution. Blood. 2011 Sep 13. [Epub ahead of print]
Nakanuma Y, Demetris AJ, Ueno Y, Quaglia A: Cholangiopathy: genetics, mechanism, and pathology. Int J Hepatol. 2012;2012:950713. Epub 2011 Sep 18.
Turnquist HR, Zhao Z, Rosborough BR, Liu Q, Castellaneta A, Isse K, Wang Z, Lang M, Beer Stolz D, Zheng XX, Demetris AJ, Liew FY, Wood KJ, Thomson AW: IL-33 Expands Suppressive CD11b+ Gr-1int and Regulatory T Cells, including ST2L+ Foxp3+ Cells, and Mediates Regulatory T Cell-Dependent Promotion of Cardiac Allograft Survival. J Immunol. 2011 Nov 1;187(9):4598-610.
Lunz JG, Ruppert K, Cajaiba M, Isse K, Bentlejewski C, Minervini M, Nalesnik M, Randhawa P, Rubin E, Sasatomi E, DeVera M, Fontes P, Humar A, Zeevi A, Demetris A. Re-examination of the Lymphocytotoxic Crossmatch in Liver Transplantation: Can C4d Stains Help in Monitoring? Am J Transplant. 2011Oct 12. doi: 10.1111/j.1600-6143.2011.03786.x. (in press).
Isse K, Lesniak A, Grama K, Roysam B, Minervini MI, Demetris AJ. Digital Transplantation Pathology: Combining Whole Slide Imaging, Multiplex Staining, and Automated Image Analysis. Am J Transplant. 2012 Jan;12(1):27-37. doi: 10.1111/j.1600-6143.2011.03797.x
Gorantla VS, Demetris AJ: Acute and chronic rejection in upper extremity transplantation: what have we learned? Hand Clin. 2011 Nov;27(4):481-93.
Zecher D, Li Q, Williams AL, Walters JT, Baddoura FK, Chalasani G, Rothstein DM, Shlomchik WD, Demetris AJ, Lakkis FG: Innate immunity alone is not sufficient for chronic rejection but predisposes healed allografts to T cell-mediated pathology. Transpl Immunol. 2011 Dec 24. [Epub ahead of print]
Zhu X, Shiba H, Fung JJ, Wang LF, Arakawa Y, Irefin S, Demetris AJ, Kelly DM: The Role of the A2a Receptor Agonist, Regadenoson, in Modulating Hepatic Artery Flow in the Porcine Small-for-Size Liver Graft.J Surg Res. 2011 Oct 27.
Feng S, Ekong UD, Lobritto SJ, Demetris AJ, Roberts JP, Rosenthal P, Alonso EM, Philogene MC, Ikle D, Poole KM, Bridges ND, Turka LA and Tchao NK: Complete Immunosuppression Withdrawal for Pediatric Liver Transplant Recipients: A Prospective, Multi-Center, Single Arm Pilot Trial. JAMA. 2012 Jan 18;307(3):283-93.
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