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Research Interests:
Dr. Demetris' interests include the immunobiology of chronic rejection and tolerance induction and the role of cytokines in growth control of biliary epithelium. Current research projects include: development of experimental animals and human protocols to enhance hematolymphoid chimerism and tolerance to solid organ allografts; pathophysiology of chronic rejection; and the role if IL-6 in biliary epithelial cell biology and chronic liver disease.
Selected Publications:
View Dr.Demetris' publications on PubMed
Lunz JG 3rd, Tsuji H, Nozaki I, Murase N, Demetris AJ. An inhibitor of cyclin-dependent kinase, stress-induced p21Waf-1/Cip-1, mediates hepatocyte mito-inhibition during the evolution of cirrhosis. Hepatology. 2005 Jun;41(6):1262-71.
Adeyi OA, Girnita AL, Howe J, Marrari M, Awadalla Y, Askar M, Martell J, Zeevi A, Shapiro R, Nalesnik M, Randhawa P, Demetris AJ, Duquesnoy RJ. Serum analysis after transplant nephrectomy reveals restricted antibody specificity patterns against structurally defined HLA class I mismatches. Transpl Immunol. 2005 Mar;14(1):53-62.
Shapiro R, Basu A, Tan H, Gray E, Kahn A, Randhawa P, Murase N, Zeevi A, Girnita A, Metes D, Ness R, Bass DC, Demetris AJ, Fung JJ, Marcos A, Starzl TE. Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with Thymoglobulin or Campath. J Am Coll Surg. 2005 Apr;200(4):505-15;
Wu T, Abu-Elmagd K, Bond G, Demetris AJ. A clinicopathologic study of isolated intestinal allografts with preformed IgG lymphocytotoxic antibodies. Hum Pathol. 2004 Nov;35(11):1332-9.
Nozaki I, Lunz JG 3rd, Specht S, Park JI, Giraud AS, Murase N, Demetris AJ. Regulation and function of trefoil factor family 3 expression in the biliary tree. Am J Pathol. 2004 Dec;165(6):1907-20.
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