William L. Bigbee, PhD
Professor of Pathology
Dr. Bigbee is a member of the University of Pittsburgh Cancer Institute. Dr Bigbee provides departmental research expertise in the areas of cancer biomarkers and mass spectrometry based proteomics methods.
University of Pittsburgh Cancer Institute
Magee-Womens Research Institute
204 Craft Avenue
Pittsburgh, PA 15213
Office Telephone: 412-641-7555
- BS - University of California, Berkeley, 1967
- PhD - University of Oregon, Institute of Molecular Biochemistry, 1974
Specialties:Cancer biomarkers, lung cancer, proteomics
Reserach ExpertiseDr. Bigbee's interests, research activities, and cumulative expertise are focused on the discovery, development and validation of cancer early detection and diagnostic molecular markers for application in translational and clinical research studies. To facilitate this research, Dr. Bigbee maintains University of Pittsburgh Cancer Institute (UPCI) programmatic appointments in the Cancer Epidemiology, and Lung and Thoracic Malignancies Programs. Dr. Bigbee's NCI-funded and related research activities include the newly-renewed UPCI SPORE in Lung Cancer in 2011 as Co-Leader of the SPORE Research Project 3 entitled "Lung Cancer Risk Prediction in the Pittsburgh Lung Screening Study". Dr. Bigbee also receives other NCI, Commonwealth of Pennsylvania, institutional, and private philanthropic grant funding to develop the use of proteomics technologies for protein expression profiling analysis and biomarker discovery for early detection/diagnosis of breast, esophageal, and lung cancer. He also is the present Chair of the NIH Cancer Biomarkers Study Section (CBSS) and serves on the Editorial Board of Cancer Research.
Selected PublicationsView Dr. Bigbee's publications on PubMed
Ostrow KL, Hoque MO, Loyo M, Brait M, Greenberg A, Siegfried JM, Grandis JR, Gaither Davis A, Bigbee WL, Rom W, Sidransky D. (2010) Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR. Clin Cancer Res 16: 3463-3472. PMID: 20592015
Zeng X, Hood, BL, Sun M, Conrads TP, Day RS, Weissfeld JL, Siegfried JM, Bigbee WL. (2010) Lung cancer serum biomarker discovery using glycoprotein capture andliquid chromatography mass spectrometry. J Proteome Res. 9: 6440-6449. PMID: 20931982
Ostroff RM, Bigbee WL, Franklin W, Gold L, Mehan M, Miller YE, Pass HI, Rom WN, Siegfried JM, Stewart A, Walker JJ, Weissfeld JL, Williams S, Zichi D, Brody EN. (2010) Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer. PLoS ONE 5(12):e15003. PMID: 21170350
Ganchev P, Malehorn DE, Bigbee WL, Gopalakrishnan V. (2011) Transfer learning of classification rules for biomarker discovery and verification from molecular profiling studies. J Biomed Inform 44 Suppl 1: S17-S23. PMID: 21571094
Zeng X, Hood BL, Zhao T, Conrads TP, Sun M, Gopalakrishnan V, Grover H, Weissfeld JL, Wilson DO, Siegfried JM, Bigbee WL. (2011) Lung cancer serum biomarker discovery using label free LC-MS/MS. J Thoracic Oncol 6: 725-734. PMID: 21304412
Li X, LeBlanc J, Truong A, Vuthoori R, Chen SS, Lustgarten JL, Roth B, Allard J, Ippoliti A, Presley LL, Borneman J, Bigbee WL, Gopalakrishnan V, Graeber TG, Elashoff D, Braun J, Goodglick L. (2011) A metaproteomic approach to study human-microbial ecosystems at the mucosal luminal interface. PLoS ONE 6: e26542. PMID: 22132074
Zhao T, Zeng X, Bateman NW, Sun M, Teng P, Bigbee WL, Rajiv Dhir R, Nelson JB, Conrads TP, Hood BL (2012) Relative quantitation of proteins in expressed prostatic secretion with a stable isotope labeled secretome standard. J Proteome Res 3: 1089-1099. PMID: 22077639
Nolen BM, Langmead CJ, Choi S, Lomakin A, Marrangoni A, Bigbee WL, Weissfeld JL, Wilson DO, Dacic S, Siegfried JM, Lokshin AE. (2012) Serum biomarker profiles as diagnostic tools in lung cancer. Cancer Biomarkers 10: 3-12.
Bigbee WL, Gopalakrishnan V, Weissfeld JL, Wilson DO, Dacic S, Lokshin AE, Siegfried JM. (2012) A multiplexed serum biomarker immunoassay panel discriminates clinical lung cancer patients from high-risk individuals found to be cancer-free by CT screening. J Thoracic Oncol (in press).
Gu S, Wang Z, Siegfried JM, Wilson DO, Bigbee WL, Pu J. (2012) Automated lobe-based airway labeling. Int J Biomedical Imaging Volume 2012 (2012), Article ID 382806, 9 pages, doi:10.1155/2012/382806