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Research Interests:
Dr. Bhargava's primary area of research is the study of predictive biomarkers in breast carcinoma and their correlation to clinical outcome. He is also interested in validation of new and informative diagnostic assays in breast and gynecologic pathology and general oncology.
Selected Publications:
Comparison of two antibodies for immunohistochemical evaluation of epidermal growth factor receptor expression in colorectal carcinomas, adenomas, and normal mucosa. Rohit Bhargava, M.D., Beiyun Chen, M.D., Ph.D., David S. Klimstra, M.D., Leonard B. Saltz, M.D., Cyrus Hedvat, M.D., Ph.D., Laura, Tang, M.D., PhD., William Gerald, M.D., PhD., Julie Teruya-Feldstein, M.D., Philip B. Paty, M.D., Jing Qin, Ph.D., Jinru Shia, M.D. Cancer. 2006 Apr 15;106(8):1857-62.
EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations. Bhargava R, Gerald WL, Li AR, Pan Q, Lal P, Ladanyi M, Chen B. Mod Pathol. 2005 Aug;18(8):1027-33.
Identification of MYCN gene amplification in neuroblastoma using chromogenic in situ hybridization (CISH): an alternative and practical method. Bhargava R, Oppenheimer O, Gerald W, Jhanwar SC, Chen B. Diagn Mol Pathol. 2005 Jun;14(2):72-6.
HER-2/neu and Topoisomerase IIa Gene Amplification and Protein Expression in Invasive Breast Carcinomas: Chromogenic In Situ Hybridization and Immunohistochemical Analyses. Bhargava R, Lal P, Chen B. Am J Clin Pathol. 2005 Jun;123(6):889-95.
Chromogenic in situ hybridization for the detection of HER-2 gene amplification in breast cancer with an emphasis on tumors with borderline and low-level amplification. Does it measure up to fluorescence in situ hybridization? Rohit Bhargava, Priti Lal, Beiyun Chen. Am J Clin Pathol. 2005;123:237-243.
Distinction of endometrial stromal sarcomas from "hemangiopericytomatous" tumors using a panel of commonly used immunohistochemical stains. Bhargava R, Shia J, Hummer AJ, Thaler HT, Tornos C, Soslow RA. Mod Pathol. 2005 Jan;18(1):40-7.
Serous Endometrial Cancers That Mimic Endometrioid Adenocarcinomas: A Clinicopathologic and Immunohistochemical Study of a Group of Problematic Cases. Darvishian, Farbod MD; Hummer, Amanda J. MS; Thaler, Howard T. PhD; Bhargava, Rohit MBBS; Linkov, Irina BS; Asher, Marina BS; Soslow, Robert A. MD. Am J Surg Pathol. 2004;28:1568-78.
Feasibility of Using Tissue Microarrays for the Assessment of HER-2 Gene Amplification by Fluorescence In Situ Hybridization in Breast Carcinoma. Rohit Bhargava, Priti Lal, Beiyun Chen. Diagn Mol Pathol. 2004 Dec;13(4):213-6.
Epstein-Barr Virus Positive Large B-Cell Lymphoma Arising in a Patient Previously Treated with Cladribine for Hairy Cell Leukemia. Rohit Bhargava, Violetta Barbashina, Daniel A. Filippa and Julie Teruya-Feldstein. Leuk Lymphoma. 2004;45(5):1043-1048.
Tyrosine Kinase Activation in Breast Carcinoma With Correlation to HER-2/neu Gene Amplification and Overexpression. Rohit Bhargava, Rizwan Naeem, Sharon Marconi, Jason Luszcz, Jane Garb, Robert Gasparini and Christopher N Otis. Hum Pathol. 2001;32:1344-50.
Analysis of Normal Epithelial Cell Specific-1 (NES1)/Kallikrein 10 mRNA Expression by in Situ Hybridization, a novel marker for breast cancer. Sanjay Dhar, Rohit Bhargava, Michael Yunes, Biao Li, Jaya Goyal, Stephen P Naber, David E Wazer and Vimla Band. Clin Cancer Res. 2001;7:3393-8.
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