W911 Biomedical Science Tower
Univeristy of Pittsburgh
Pittsburgh, PA.15213

Office Telephone: (412) 648-9349
Fax: (412) 624-7736
E-mail: zqzhu@pitt.edu

We are interesting in studying the antigen presenting capacity of dendritic cells. This is a hot area at the moment related to understand how immune responses to immunoglobulin G occur in rheumatoid arthritis. Immune responses to self proteins, termed autoantigens, are characteristic of rheumatoid arthritis and other autoimmune disorders, but little is known about how these responses are initiated. A major goal of the project is to discover ways to dampen or eliminate aggressive immune responses against self, which cause much pain and suffering in affected patients.

1. Luo GM, Zhu ZQ, Ding L, Gao G, Sun QA, Liu Z, Yang TS and Shen JC. Generation of Selenium-containing Abzyme by Using Chemical Mutation. Biochem.Biophys.Res.Comm. 1994, 98, 1240-1247.
2. Zhu ZQ, Ding Lan, Luo GM, Liu Z, Sun QA, Yang TS and Shen JC. Some Physicochemical and Enzymic Properties of Selenium-containing Abzyme. Biochem.Biophys.Res.Comm. 1994, 202, 1645-1650.
3. Zhenqi Zhu, Lan Ding, Guimin Luo, Gui Gao, QiAn Sun, Zhi Liu, Tongshu Yang, and Jiacong Shen, Generation of Catalytic antibody with glutathione peroxidase activity by using chemical mutation, In: Better Living Through Innovative Biochemical Engineering, Proceedings of the Third Asia-Pacific Biochemical Engineering Conference, June 15-15, 1994. Singapore, Editors, W.U.Teo, M.G.Yap and S.K.W.Oh, Department of Chemical Engineerring and Bioprocessing Technology Unit, National University of Singapore, 333-335.
4. Ding L, Zhu ZQ, Luo GM, Sun QA, Yang TS and Shen JC. Studies on Artificial Imitation of Glutathione Peroxidase by Chemical Mutation. Chemical Research in Chinese Universities. 1994, 10, 131-133.
5. Zhu ZQ, Luo GM, Gou SJ, Zhang DA and Shen JC. Effects on Chemical Modification on the Stability and Properties of the PPK. Chinese Biochemical Journal. 1994, 10, 692-696.
6. Luo GM, Ding L, Zhu ZQ, Gao G, Sun QA, Liu Z, Yang TS and Shen JC. A New Strategy for Generating Selenium-containing Abzyme. Ann. New York Acad. Sci. 1995, 750, 277-283.
7. Zhu ZQ, Luo GM, Ding L, Gao G, Sun QA, Yang TS and Shen JC. Studies on the Properties of Se-containing Abzyme. Acta Biochimica et Biophysica Sinica. 1995, 27(4), 431-435.
8. Zhu ZQ, Luo GM, Ding L, Sun QA, Yang TS and Shen JC. Studies on Preparation and its Properties of Tripeptide with Activity of GPX. Chinese Biochemical Journal. 1995, 11, 338-342.
9. Luo GM, Liu WH, Sun QA, Ding L, Zhu ZQ, Yan GL and Yang TS. Preparation of Bifunctional Enzyme with Both Superoxide Dismutase and Glutathione Peroxidase Activities by Using Chemical Mutation. Ann. New York Acad. Sci. 1996, 799, 50-55.
10. Zhu ZQ, Liu Jin, Wu YH, Zhang YM and Ma DL. Overexpression and stability of recombinant human chimeric protein rhGM-CSF/HSAD3 (GM-HSAD3) in E.coli. Chinese Biochemical Journal. 1996, 12(3), 284-288.
11. Ding L, Zhu ZQ, Luo GM, Xing H, Liu Z, Yang TS and Shen JC, Imitation of glutathione peroxidase by chemical modification of monoclonal antibodies. Chinese Biochemical Journal. 1996, 12(5): 553-558.
12. Lan Ding, Zi Liu, Zhenqi Zhu, Guimin Luo, Daqing Zhao and Jiazuan Ni. Biochemical characterization of selenium-containing catalytic antibody as a cytosolic glutathione peroxidase mimic. Biochem, J. 1998, 332: 251-255(London).