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Research Interests:
To develop HGF as a new therapeutic strategies to modify renal cell survival, repair, and extracellular matrix remodeling, thereby to alter the course of clinical chronic renal disease.
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Grants & Awards
- 2001:1st prize of the 12th Annual Pathology Research Day Presentations, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, USA
- 2001:AHA fellowship, Pennsylvania-Delaware Affiliate Postdoctoral Fellowship, American Heart Association
- 2000 Pathology Postdoctoral Research Training Grant (PPRTG), Department of Pathology, University of Pittsburgh School of Medicine.
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Publications:
- Junwei Yang, Ryan W. Shultz, Wendy M. Mars, Rodney E. Wegner, Yingjian Li, Chunsun Dai, Kari Nejak, and Youhua Liu. 2002. Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy.
J. Clin. Invest. 110:1525-1538
- Yang J, Dai C, Liu Y. 2002. Hepatocyte Growth Factor Gene Therapy and Angiotensin II Blockade Synergistically Attenuate Renal Interstitial Fibrosis in Mice.
J Am Soc Nephrol. 13:2464-77
- Yang J, Liu Y. 2002. Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol. 13:96-107
- Dai C, Yang J, Liu Y. 2002. Single injection of naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in mice. J Am Soc Nephrol. ;13:411-22.
- Yang J, Liu Y. 2001. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol. 159:1465-75
- Yang J, Dai C, and Liu Y. .2001. Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice. Gene Therapy 8:1470-1479
- Yang J, Chen S, Huang L, Michalopoulos GK, Liu Y.. 2001. Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth. Hepatology. 33:848-59
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