E1516 Biomedical Science Tower
200 Lothrop Street
University of Pittsburgh
School of Medicine
Pittsburgh, PA 15261

Office Telephone: (412) 624-6605
Fax: (412) 624-6666
E-mail: hirot@imap.pitt.edu

Hepatocyte Apoptosis and Proliferation by Cytokines.

1. Tsuji H, Harada A, Mukaida N, Nakanuma Y, Bluethmann H, Kaneko S, Yamakawa K, Nakamura SI, Kobayashi KI, Matsushima K: Tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis. Infect Immun 1997 May;65(5):1892-8
2. Tsuji H, Mukaida N, Harada A, Kaneko S, Matsushita E, Nakanuma Y, Tsutsui H, Okamura H, Nakanishi K, Tagawa Y, Iwakura Y, Kobayashi K, Matsushima K: Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes-primed IFN-gamma-deficient mice by a concomitant reduction of TNF-alpha, IL-12, and IL-18 production. J Immunol 1999 Jan 15;162(2):1049-55
3. Natsume M, Tsuji H, Harada A, Akiyama M, Yano T, Ishikura H, Nakanishi I, Matsushima K, Kaneko S, Mukaida N: Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6-deficient mice. J Leukoc Biol 1999 Oct;66(4):601-8
4. Nishihori H, Tsuji H, Wang H, Tahara H, Akiyama M, Ogawa Y, Matsushima K, Iwakura Y, Mukaida N: Participation of endogenously produced interferon gamma in interleukin 4-mediated tumor rejection. Hum Gene Ther 2000 Mar 20;11(5):659-68
5. Ezure T, Sakamoto T, Tsuji H, Lunz JG 3rd, Murase N, Fung JJ, Demetris AJ: The development and compensation of biliary cirrhosis in interleukin-6-deficient mice. Am J Pathol 2000 May;156(5):1627-39
6. Yokomuro S, Tsuji H, Lunz JG, Sakamoto T, Ezure T, Murase N, Demetris AJ.: Growth Control of Human Biliary Epithelial Cells by Interleukin 6, Hepatocyte Growth Factor, Transforming Growth Factor beta1, and Activin A: Comparison of a Cholangiocarcinoma Cell Line With Primary Cultures of Non-neoplastic Biliary Epithelial Cells. Hepatology. 2000 Jul;32(1):26-35.
7. Sakamoto T, Ezure T, Lunz J, Murase N, Tsuji H, Fung JJ, Demetris AJ: Concanavalin A simultaneously primes liver epithelial and hematopoietic progenitor cells for parallel expansion during liver regeneration following partial hepatectomy in mice. Hepatology (in press)