Irina L. Tourkova, M.D., Ph.D.

Welcome to Dr. Tourkova's Home Page!

Dr. Tourkova is a research associate at Dr. Shurin's laboratory


Office Location:

733 Scaife Hall
3550 Terrace St.
Pittsburgh, PA 15261



Contact Information:

Office Telephone: (412) 648-9831
Fax: (412) 648-8158
E-mail: turkovai@upmc.edu



Research Interests:

    Tumor Immunology

Publications:

  1. Shurin GV, Chatta G, Tourkova IL, Zorina TD, Esche C, Shurin MR. Regulation of dendritic cell expansion in aged athymic nude mice by FLT3 ligand, Experimental Gerontology, 39: 339-348, 2004.
  2. Tourkova IL, Yamabe K, Foster B, Chatta G, Perez L, Shurin GV, Shurin MR. Murine Prostate Cancer Inhibits Both in Vivo and in Vitro Generation of Dendritic Cells from Bone Marrow Precursors, The Prostate, 59: 203-213, 2004.
  3. Balkir L, Tourkova IL, Makarenkova VP, Shurin GV, Robbins PD, Yin X-M, Chatta GS, Shurin MR. Comparative analysis of dendritic cells transduced with different anti-apoptotic molecules: sensitivity to tumor-induced apoptosis, J Gene Med, 6: 537-544, 2004.
  4. Shurin GV, Tourkova IL, Chatta GS, Schmidt G, Wei S, Djeu JY, Shurin MR. Small Rho GTPases Regulate Antigen Presentation in Dendritic Cells, J Immunol, 174: 3394-3400, 2005.
  5. Shurin GV, Ferris R,, Tourkova IL, Lori Perez, Lokshin A, Balkir L, Collins B, Chatta GS, Shurin MR. Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo, J Immunol, 174: 5490-5498, 2005.
  6. Perez L, Shurin MR, Collins B, Kogan D, Tourkova IL, Shurin GV. Comparative analysis of CD1a, S-100, CD83, and CD11c human dendritic cells in normal, premalignant, and malignant tissues, Histology and Histopathology,20:1165-1172, 2005.
  7. Tourkova IL, Shurin GV, Chatta GS, Perez L, Finke J, Whiteside T, Ferrone S, Shurin MR. Restoration by IL-15 of MHC class I antigen processing machinery in human dendritic cells inhibited by tumor-derived gangliosides, J Immunol, 175:3045-3052, 2005.
  8. Feng R, Ni H-M, Wang SY, Tourkova IL, Shurin MR, Harada H, Yin X-M. Cianidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress, The Journal of Biological Chemistry, 282: 13468-13476, 2007.
  9. Tourkova IL, Shurin GV, Wei S, Shurin MR. Small rho GTPases mediate tumor-induced inhibition of endocytic activity of dendritic cells. J Immunol, 178:7787-93, 2007.

feedbackHome