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Office Location:
Rm. 711 Scaife Hall |
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Contact Information:
Office Telephone: (412) 624-0613 |
| Latha Satish, Ph.D. Welcome to Dr. Satish's Home Page! |
| Dr. Satish is a post-doctoral fellow in the Division of Clinical Medicine with Dr. Wells. More information about this division is available here. |
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Office Location:
Rm. 711 Scaife Hall |
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Contact Information:
Office Telephone: (412) 624-0613 |
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Research Interests:
Wound healing is a complex biological process that involves migration and proliferation of cells to repopulate the defect, synthesis of extracellular matrix proteins and remodeling of scar to re-establish the organ integrity. Further complicating this is that to regenerate functional skin, the dermal and epidermal layers should act in an orchestrated manner. How the major cells of each layer, fibroblasts in the dermis and keratinocytes in the epidermis coordinate their response is unknown. We hypothesize that select chemokines and growth factors might be master communicators to synchronize the resolution phase between the two cell types.
To test this hypothesis the present study is directed towards the role played by the CXC- chemokines (IP-9 & IP-10) during wound healing with special reference to keratinocytes and fibroblasts the two major cells involved during the healing process. I am determining how these chemokines, produced by mature basal keratinocytes and endothelial cells of the neovasculature affect growth factor-stimulated processes during wound repair. Our initial findings suggest a model in which this chemokine family promotes motility and re-epithelialisation when undifferentiated keratinocytes are present but turns dermal wound dermal fibroblasts to contractile behaviour required for resolution when an intact, differentiated keratinocyte layer is present.
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Publications:
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