Publications in Refereed Journals: 2006 - 2011
  1. Abraham SC, Kamath PS, Eghtesad B, Demetris AJ, Krasinskas AM. Liver transplantation in precirrhotic biliary tract disease: Portal hypertension is frequently associated with nodular regenerative hyperplasia and obliterative portal venopathy. Am J Surg Pathol. 2006 Nov;30(11):1454-61. PubMed PMID: 17063088.
  2. de Vera ME, Dvorchik I, Tom K, Eghtesad B, Thai N, Shakil O, Marcos A, Demetris A, Jain A, Fung JJ, Ragni MV. Survival of liver transplant patients coinfected with HIV and HCV is adversely impacted by recurrent hepatitis C. Am J Transplant. 2006 Dec;6(12):2983-93. PubMed PMID: 17062005.
  3. Demetris AJ. Distinguishing between recurrent primary sclerosing cholangitis and chronic rejection. Liver Transpl. 2006 Nov;12(11 Suppl 2):S68-72. Review. PubMed PMID: 17051552.
  4. Li S, Salgar SK, Thanikachalam M, Murdock AD, Gammie JS, Demetris AJ, Zeevi A, Pham SM. CTLA4-Ig-based conditioning regimen to induce tolerance to cardiac allografts. J Surg Res. 2006 Dec;136(2):238-46. PubMed PMID:17046021.
  5. Luo JH, Ren B, Keryanov S, Tseng GC, Rao UN, Monga SP, Strom S, Demetris AJ, Nalesnik M, Yu YP, Ranganathan S, Michalopoulos GK. Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas. Hepatology. 2006 Oct;44(4):1012-24. PubMed PMID: 17006932; PubMed Central PMCID: PMC1769554.
  6. Banff Working Group, Demetris AJ, Adeyi O, Bellamy CO, Clouston A, Charlotte F, Czaja A, Daskal I, El-Monayeri MS, Fontes P, Fung J, Gridelli B, Guido M, Haga H, Hart J, Honsova E, Hubscher S, Itoh T, Jhala N, Jungmann P, Khettry U, Lassman C, Ligato S, Lunz JG 3rd, Marcos A, Minervini MI, Mölne J, Nalesnik M, Nasser I, Neil D, Ochoa E, Pappo O, Randhawa P, Reinholt FP, Ruiz P, Sebagh M, Spada M, Sonzogni A, Tsamandas AC, Wernerson A, Wu T, Yilmaz F. Liver biopsy interpretation for causes of late liver allograft dysfunction. Hepatology. 2006 Aug;44(2):489-501. Review. PubMed PMID: 16871565.
  7. Wu T, Bond G, Martin D, Nalesnik MA, Demetris AJ, Abu-Elmagd K. Histopathologic characteristics of human intestine allograft acute rejection in patients pretreated with thymoglobulin or alemtuzumab. Am J Gastroenterol. 2006 Jul;101(7):1617-24. PubMed PMID: 16863569.
  8. Demetris AJ, Kelly DM, Eghtesad B, Fontes P, Wallis Marsh J, Tom K, Tan HP, Shaw-Stiffel T, Boig L, Novelli P, Planinsic R, Fung JJ, Marcos A. Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndrome. Am J Surg Pathol. 2006 Aug;30(8):986-93. PubMed PMID: 16861970.
  9. Han C, Demetris AJ, Stolz DB, Xu L, Lim K, Wu T. Modulation of Stat3 activation by the cytosolic phospholipase A2alpha and cyclooxygenase-2-controlled prostaglandin E2 signaling pathway. J Biol Chem. 2006 Aug 25;281(34):24831-46. PubMed PMID: 16790433.
  10. Demetris AJ, Lunz JG 3rd, Specht S, Nozaki I. Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease. World J Gastroenterol. 2006 Jun 14;12(22):3512-22. Review. PubMed PMID: 16773708. Nakao A, Toyokawa H, Kimizuka K, Nalesnik MA, Nozaki I, Bailey RJ, Demetris AJ, Starzl TE, Murase N. Simultaneous bone marrow and intestine transplantation promotes marrow-derived hematopoietic stem cell engraftment and chimerism. Blood. 2006 Aug 15;108(4):1413-20. PubMed PMID: 16638929; PubMed Central PMCID: PMC1895884.
  11. Lee JS, Heo J, Libbrecht L, Chu IS, Kaposi-Novak P, Calvisi DF, Mikaelyan A, Roberts LR, Demetris AJ, Sun Z, Nevens F, Roskams T, Thorgeirsson SS. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med. 2006 Apr;12(4):410-6. PubMed PMID: 16532004.
  12. Habib S, Shakil O, Couto OF, Demetris AJ, Fung JJ, Marcos A, Chopra K. Caroli's disease and orthotopic liver transplantation. Liver Transpl. 2006 Mar;12(3):416-21. PubMed PMID: 16498655.
  13. Habib S, Berk B, Chang CC, Demetris AJ, Fontes P, Dvorchik I, Eghtesad B, Marcos A, Shakil AO. MELD and prediction of post-liver transplantation survival. Liver Transpl. 2006 Mar;12(3):440-7. PubMed PMID: 16498643.
  14. Kiyomoto T, Toyokawa H, Nakao A, Kaizu T, Demetris AJ, Starzl TE, Murase N. The difficulty of eliminating donor leukocyte microchimerism in rat recipients bearing established organ allografts. Transplantation. 2006 Feb 15;81(3):438-44. PubMed PMID: 16477232; PubMed Central PMCID: PMC2989846.
  15. Reed EF, Demetris AJ, Hammond E, Itescu S, Kobashigawa JA, Reinsmoen NL, Rodriguez ER, Rose M, Stewart S, Suciu-Foca N, Zeevi A, Fishbein MC; International Society for Heart and Lung Transplantation. Acute antibody-mediated rejection of cardiac transplants. J Heart Lung Transplant. 2006 Feb;25(2):153-9. Review. PubMed PMID: 16446213.
  16. Toyokawa H, Nakao A, Stolz DB, Romanosky AJ, Nalesnik MA, Neto JS, Kaizu T, Demetris AJ, Murase N. 3D-confocal structural analysis of bone marrow-derivedrenal tubular cells during renal ischemia/reperfusion injury. Lab Invest. 2006 Jan;86(1):72-82. PubMed PMID: 16258520.
  17. Zeng G, Awan F, Otruba W, Muller P, Apte U, Tan X, Gandhi C, Demetris AJ, Monga SP: Wnt'er in liver: Expression of Wnt and frizzled genes in mouse. Hepatology. Jan;45(1):195-204, 2007. PMID: 17187422
  18. Morelli AE, Coates PT, Shufesky WJ, Barratt-Boyes SM, Fung JJ, Demetris AJ, Thomson AW. Growth factor-induced mobilization of dendritic cells in kidney and liver of rhesus macaques: implications for transplantation. Transplantation. 2007 Mar 15;83(5):656-62. PMID: 17353790
  19. Solez K, Colvin RB, Racusen LC, Sis B, Halloran PF, Birk PE, Campbell PM, Cascalho M, Collins AB, Demetris AJ, Drachenberg CB, Gibson IW, Grimm PC, Haas M, Lerut E, Liapis H, Mannon RB, Marcus PB, Mengel M, Mihatsch MJ, Nankivell BJ, Nickeleit V, Papadimitriou JC, Platt JL, Randhawa P, Roberts I, Salinas-Madriga L, Salomon DR, Seron D, Sheaff M, Weening JJ. Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant. 2007 Mar;7(3):518-26.
  20. Dvorchik I, Demetris AJ, Geller DA, Carr BI, Fontes P, Finkelstein SD, Cappella NK, Marsh JW: Prognostic Models in Hepatocellular Carcinoma (HCC) and Statistical Methodologies Behind Them. Curr Pharm Des.13(15):1527-32,2007.
  21. Richardson MM, Jonsson JR, Powell EE, Brunt EM, Neuschwander-Tetri BA, Bhathal PS, Dixon JB, Weltman MD, Tilg H, Moschen AR, Purdie DM, Demetris AJ, Clouston AD: Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction. Gastroenterology. 2007 Jul;133(1):80-90. PMID: 17631134
  22. Shaikh OS, Demetris AJ: Idiopathic posttransplantation hepatitis? Liver Transpl. Jul;13(7):943-946, 2007. PMID: 17600346 Song JS, Murase N, Demetris AJ, Michalopoulos GK, Ochoa ER: Protection from acute cellular injury using Sleeping Beauty mediated telomerase gene transfer. Biochem Biophys Res Commun. Nov 16;363(2):253-6,2007. PMCID: PMC2693062
  23. Lunz JG 3rd, Specht SM, Murase N, Isse K, Demetris AJ: Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6/signal transducer and activator of transcription 3 activity. Hepatology. Dec;46(6):1946-59, 2007. PMID: 17935227
  24. Anderson BE, Zheng H, Taylor PA, Matte-Martone C, McNiff JM, Jain D, Demetris AJ, Panoskaltsis-Mortari A, Ager A, Blazar BR, Shlomchik MJ, Shlomchik WD: Memory T cells in GVHD and GVL. Biol Blood Marrow Transplant. 2008 Jan;14(1 Suppl 1):19-20. Erratum in: Biol Blood Marrow Transplant. 2008 Nov;14(11):1317-8. PMID: 19418622
  25. Lim K, Han C, Xu L, Isse K, Demetris AJ, Wu T.Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids. Cancer Res. Jan 15;68(2):553-60, 2008. PMID: 18199552
  26. Demetris AJ, Specht S, Nozaki I, Lunz JG 3rd, Stolz DB, Murase N, Wu T: Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes. J Hepatol. Feb;48(2):276-288, 2008. PMCID: PMC2263141
  27. Anderson BE, Taylor PA, McNiff JM, Jain D, Demetris AJ, Panoskaltsis-Mortari A, Ager A, Blazar BR, Shlomchik WD, Shlomchik MJ: Effects of donor T cell trafficking and priming site on GVHD induction by naive and memory phenotype CD4 T cells. Blood. 2008 May 15;111(10):5242-51. PMCID: PMC2384145
  28. Toyokawa H, Nakao A, Bailey RJ, Nalesnik MA, Kaizu T, Lemoine JL, Ikeda A, Tomiyama K, Papworth GD, Huang L, Demetris AJ, Starzl TE, Murase N: Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation. Liver Transpl. Mar;14(3):346-57, 2008. PMCID: PMC3022430
  29. Adeyi OA, Randhawa PA, Nalesnik MA, Ochoa ER, Abu-Elmagd KM, Demetris AJ, Wu T: Posttransplant adenoviral enteropathy in patients with small bowel transplantation. Arch Pathol Lab Med. Apr;132(4):703-5, 2008. PMID: 18384224
  30. Krasinskas AM, Demetris AJ, Poterucha JJ, Abraham SC: The prevalence and natural history of untreated isolated central perivenulitis in adult allograft livers. Liver Transpl. May;14(5):625-32, 2008. PMID: 18433038
  31. Drachenberg CB, Odorico J, Demetris AJ, Arend L, Bajema IM, Bruijn JA, Cantarovich D, Cathro HP, Chapman J, Dimosthenous K, Fyfe-Kirschner B, Gaber L, Gaber O, Goldberg J, Honsová E, Iskandar SS, Klassen DK, Nankivell B, Papadimitriou JC, Racusen LC, Randhawa P, Reinholt FP, Renaudin K, Revelo PP, Ruiz P, Torrealba JR, Vazquez-Martul E, Voska L, Stratta R, Bartlett ST, Sutherland DE: Banff Schema for Grading Pancreas Allograft Rejection: Working Proposal by a Multi-Disciplinary International Consensus Panel. Am J Transplant. Jun;8(6):1237-49, 2008. PMID: 18444939
  32. Abraham SC, Poterucha JJ, Rosen CB, Demetris AJ, Krasinskas AM: Histologic Abnormalities are Common in Protocol Liver Allograft Biopsies From Patients With Normal Liver Function Tests. Am J Surg Pathol. 2008 Jul;32(7):965-73. PMID: 18460980 Limaye PB, Alarcón G, Walls AL, Nalesnik MA, Michalopoulos GK, Demetris AJ, Ochoa ER: Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development. Lab Invest. Aug;88(8):865-72, 2008. PMCID: PMC2631390
  33. Balan V, Ruppert K, Demetris AJ, Ledneva T, Duquesnoy RJ, Detre KM, Wei YL, Rakela J, Schafer DF, Roberts JP, Everhart JE, Wiesner RH: Long-term outcome of human leukocyte antigen mismatching in liver transplantation: results of the National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database.Hepatology.Sep;48(3):878-88, 2008. PMID: 18752327
  34. Demetris AJ, Lunz, III JG, Randhawa P, Wu T, Nalesnik M, Thomson AW: Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective. Transpl Int. Jan 1;22(1Special Review Issue: Minimization of Immunosuppression):120-141, 2009. PMID: 18980624
  35. Abu-Elmagd KM, Costa G, Bond GJ, Wu T, Murase N, Zeevi A, Simmons R, Soltys K, Sindhi R, Stein W, Demetris A, Mazariegos G: Evolution of the immunosuppressive strategies for the intestinal and multivisceral recipients with special reference to allograft immunity and achievement of partial tolerance. Transpl Int. Jan 1;22(1Special Review Issue: Minimization of Immunosuppression):96-109, 2009. PMID: 18954362
  36. Ashokkumar C, Talukdar A, Sun Q, Higgs BW, Janosky J, Wilson P, Mazariegos G, Jaffe R, Demetris A, Dobberstein J, Soltys K, Bond G, Thomson AW, Zeevi A, Sindhi R: Allospecific CD154+ T Cells Associate with Rejection Risk After Pediatric Liver Transplantation. Am J Transplant. Jan;9(1):179-91, 2009. PMCID: PMC2997472
  37. Minervini MI, Ruppert K, Fontes P, Volpes R, Vizzini G, de Vera ME, Gruttadauria S, Miraglia R, Pipitone L, Marsh JW, Marcos A, Gridelli B, Demetris AJ: Liver biopsy findings from healthy potential living liver donors: Reasons for disqualification, silent diseases and correlation with liver injury tests. J Hepatol. Mar;50(3):501-10, 2009. PMID: 19155086
  38. de Vera ME, Lopez-Solis R, Dvorchik I, Campos S, Morris W, Demetris AJ, Fontes P, Marsh JW: Liver transplantation using donation after cardiac death donors: long-term follow-up from a single center. Am J Transplant. Apr;9(4):773-81, 2009. PMID: 19344466
  39. Sumpter TL, Lunz Iii JG, Castellaneta A, Matta B, Tokita D, Turnquist HR, Mazariegos GV, Demetris AJ, Thomson AW: Dendritic cell immunobiology in relation to liver transplant outcome. Front Biosci (Elite Ed). Jun 1;1:99-114, 2009. PMID: 19482629
  40. Mavrakis A, Demetris A, Ochoa ER, Rabinovitz M: Hereditary Hemorrhagic Telangiectasia of the Liver Complicated by Ischemic Bile Duct Necrosis and Sepsis: Case Report and Review of the Literature. Dig Dis Sci. Jul;55(7):2113-7, 2010. PMID: 19757046
  41. Martin T, Schwartz J, Demetris A, Comstock J, Lowichik A, Book L: Plasmapheresis treatment of antibody-mediated rejection in an A2 donor to O pediatric liver transplant recipient. Pediatr Transplant. Feb;15(1):E15-8, 2011 PMID: 19691524
  42. Isse K, Specht SM, Lunz JG 3rd, Kang LI, Mizuguchi Y, Demetris AJ: Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans. Hepatology. Mar;51(3):869-80, 2010. PMID: 20043322
  43. Kelly DM, Zhu X, Shiba H, Irefin S, Trenti L, Cocieru A, Diago T, Wang LF, Quintini C, Chen Z, Alster J, Nakagawa S, Miller C, Demetris A, Fung JJ: Adenosine restores the hepatic artery buffer response and improves survival in a porcine model of small-for-size syndrome. Liver Transpl. Nov;15(11):1448-57, 2009. PMID: 19877203
  44. Demetris AJ: Evolution of hepatitis C virus in liver allografts.Liver Transpl. Nov;15 Suppl 2:S35-41, 2009. PMID: 19876940
  45. Toso C, Isse K, Demetris AJ, Dinyari P, Koh A, Imes S, Kin T, Emamaullee J, Senior P, Shapiro AM: Histologic graft assessment after clinical islet transplantation. Transplantation. Dec 15;88(11):1286-93, 2009. PMID: 19996928
  46. Isse K, Grama K, Abbott IM, Lesniak A, Lunz JG, Lee WMF, Specht S, Corbitt NS, Mizuguchi Y, Roysam B, Demetris AJ: Adding Value to Liver (and Allograft) Biopsy Evaluation Using a Combination of Multiplex Quantum Dot Immunostaining, High Resolution Whole Slide Digital Imaging, and Automated Image Analysis, Clin Liver Dis. 2010 Nov;14(4):669-85. PMID: 21055689
  47. Matte-Martone C, Wang X, Anderson B, Jain D, Demetris AJ, McNiff J, Shlomchik MJ, Shlomchik WD: Recipient B Cells Are Not Required For GVHD Induction. Biol Blood Marrow Transplant. Sep;16(9):1222-1230, 2010. PMCID: PMC3135976
  48. Zecher D, Li Q, Oberbarnscheidt MH, Demetris AJ, Shlomchik WD, Rothstein DM, Lakkis FG: NK Cells Delay Allograft Rejection in Lymphopenic Hosts by Downregulating the Homeostatic Proliferation of CD8+ T Cells. J Immunol. Jun 15;184(12):6649-57, 2010. PMID: 20483732
  49. Han C, Bowen WC, Li G, Demetris AJ, Michalopoulos GK, Wu T: Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transformed hepatocyte growth. Hepatology. Aug;52(2):644-55, 2010. PMCID: PMC3013516
  50. Thomson AW, Geller DA, Gandhi C, Murase N, Demetris AJ, Beer-Stolz D. Hepatic antigen-presenting cells and regulation of liver transplant outcome. Immunol Res. 2011 Aug;50(2-3):221-7. PubMed PMID: 21717072.
  51. Ueki S, Castellaneta A, Yoshida O, Ozaki K, Zhang M, Kimura S, Isse K, Ross M, Shao L, Stolz DB, Thomson AW, Demetris AJ, Geller DA, Murase N. Hepatic B7 homolog 1 expression is essential for controlling cold ischemia/reperfusion injury after mouse liver transplantation. Hepatology. 2011 Jul;54(1):216-28. doi: 10.1002/hep.24360. PubMed PMID: 21503939; PubMed Central PMCID: PMC3125416.
  52. Oberbarnscheidt MH, Walch JM, Li Q, Williams AL, Walters JT, Hoffman RA, Demetris AJ, Gerard C, Camirand G, Lakkis FG. Memory T cells migrate to and reject vascularized cardiac allografts independent of the chemokine receptor CXCR3. Transplantation. 2011 Apr 27;91(8):827-32. PubMed PMID: 21285915; PubMed Central PMCID: PMC3073028.
  53. Li H, Matte-Martone C, Tan HS, Venkatesan S, McNiff J, Demetris AJ, Jain D, Lakkis F, Rothstein D, Shlomchik WD. Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells. J Immunol. 2011 Jan 1;186(1):230-41. PubMed PMID: 21098219.