Current Projects:

Source:	NIH (HLB), R01 HL63700-01
Title:	Extracellular superoxide dismutase in pulmonary fibrosis
Role on Project:	Principal Investigator
Specific Aims:	This grant studies the importance of extracellular superoxide in the pathogenesis of pulmonary fibrosis with particular focus on how oxidatively modified matrix proteins contribute to the pathogenesis.

Source:	Pittsburgh Foundation
Title:	Glycation of Extracellular superoxide dismutase in diabetes: Implications for diabetes-related vascular disease
Role on Project:	Principal Investigator
Specific Aims:	This grant investigates the effect nonenzymatic glycation of EC-SOD's heparin-binding domain has on the levels of EC-SOD in the interstitium of human arteries.

Source:	NIH (NINDS)
Title:	Free radicals and phosphotyrosine signaling in the Parkinsonian 6-OHDA model
Role on Project:	Co-Investigator
Specific Aims:	This grant studies the effect of reactive oxygen and nitrogen species on phosphotyrosine signaling in a model of Parkinson's disease.

Source:	American Parkinson Disease Association
Title:	Extracellular superoxide dismutase in Parkinson's Disease
Role on Project:	Principal Investigator
Specific Aims:	This grant studies the immunodistribution of EC-SOD in the striatum and substantia nigra of wild type and EC-SOD transgenic mice.

LIST of CURRENT RESEARCH/CLINICAL INTERESTS:

Antioxidant enzymes in pulmonary fibrosis. Antioxidant enzymes in vascular biology. Oxidants and antioxidants in Parkinson's disease. Oxidants and antioxidants in learning and memory. Oxidative modification of proteins. Asbestos related disease. Molecular and Pulmonary Pathology