Tim D. Oury, MD, PhD
  Department of Pathology
  University of Pittsburgh School of Medicine


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    • PUBLICATIONS

    Refereed Articles:


    1. Oury TD, Ho YS, Piantadosi CA, Crapo JD (1992) Extracellular superoxide dismutase, nitric oxide and central nervous system O2 toxicity. Proc Natl Acad Sci USA 89, 9715-9719
    2. Crapo JD, Oury TD, Rabouille C, Slot JW, Chang LY (1992) Copper, zinc superoxide dismutase is primarily a cytosolic protein in human cells. Proc Natl Acad Sci USA 89, 10405-10409
    3. Zhang J, Su Y, Oury TD, Piantadosi CA (1993) Cerebral amino acid, norepinephrine and nitric oxide metabolism in CNS oxygen toxicity. Brain Research 606, 56-62
    4. Oury TD, Piantadosi CA, Crapo JD (1993) Cold-induced brain edema in mice: Involvement of extracellular superoxide dismutase and nitric oxide. J Biol Chem 268, 15394-15398
    5. Chu CT, Oury TD, Enghild JJ, Pizzo SV (1994) Adjuvant-free in vivo targeting: Antigen delivery by a2-macroglobulin enhances antibody formation. J Immunol 152, 1538-1545
    6. Oury TD, Chang L, Marklund SL, Crapo JD (1994) Immunocytochemical localization of extracellular superoxide dismutase in human lung. Lab Invest 70, 889-898
    7. Oury TD, Tatro L, Ghio AJ, Piantadosi CA (1995) Nitration of tyrosine by hydrogen peroxide and nitrite. Free Rad Res 23, 537-547
    8. Oury TD, Day BJ, Crapo JD (1995) Extracellular superoxide dismutase in pulmonary vessels and airways of humans and baboons. Free Rad Biol Med 20, 957-965
    9. Oury TD, Crapo JD, Valnickova Z, Enghild JJ (1996) Human extracellular superoxide dismutase is a tetramer composed of two disulfide linked dimers: A simplified high yield purification of EC-SOD. Biochem J 317, 51-57
    10. Gottfredsson M, Oury TD, Bernstein CB, Carpenter C, and Bartlett JA (1996) Lymphoma of the pituitary gland: An unusual presentation of CNS lymphoma in AIDS. Am J Med 5, 563-564
    11. Folz RJ, Guan J, Seldin MF, Oury TD, Enghild JJ, Crapo JD (1997) Mouse extracellular superoxide dismutase: Primary structure, tissue-specific gene expression, chromosomal localization and lung in situ hybridization Am J Resp Cell Mol Biol 17, 393-403
    12. Palmer SP, Layish DT, Kussin PS, Oury TD, Davis RD, Tapson VF (1998) Lung transplantation for Williams-Campbell Syndrome: A case report Chest 113, 534-537
    13. Berggård T, Oury TD, Thøgersen IB, Åkerström B, Enghild, JJ (1998) The tissue distribution of a1-microglobulin: Immunochemical and biochemical studies. J. Histochem Cytochem 46, 887-893
    14. Boggess KA, Oury TD, Kay HH, Crapo JD (1998) Analysis of extracellular superoxide dismutase in normal and preeclamptic placentas. Placenta 19, 417-422
    15. Howell DN, Valnickova Z, Oury TD, Miller SE, Sanfilippo FP, Enghild JJ (1998) Expression of a copper-containing amine oxidase by human ciliary body. Molecular Vision 4: 15
    16. Levine ED, Hochrein EC, Brady T, Oury TD, Carlsson LM, Marklund SL, Crapo JD (1998) Molecular manipulations of extracellular superoxide dismutase: Functional importance for learning and memory. Behavior Genetics 28, 381-390
    17. Mooney EE, Dodd LG, Oury TD, Burchette J, Layfield LJ, Scher RL (1999) Middle ear carcinoid: An indolent tumor with metastatic potential. Head & Neck Surgery 21, 72-77
    18. Sheng H, Bart R, Oury TD, Pearlstein RD, Day BJ, Crapo JD, Warner DS (1999) Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia. Neurosci 88, 185-191
    19. Enghild JJ. Thogersen IB. Oury TD. Valnickova Z. Højrup P. Crapo JD. (1999) The heparin-binding domain of extracellular superoxide dismutase is proteolytically processed intracellularly during biosynthesis. J Biol Chem 274, 14818-22.
    20. Oury TD, Card JP, Klann E (1999) Localization of extracellular superoxide dismutase in adult mouse brain. Brain Research, 850, 96-103.
    21. Boggess KA, Kay HH, Crapo JD, Suliman H, Moore WF, Suliman HB, Oury TD. (2000) Differential localization of placental extracellular superoxide dismutase as pregnancy progresses: relationship to placental vascular development. Am J Obstet Gynecol, 183, 199-205.
    22. Fattman CL, Enghild JJ, Crapo JD, Schaefer LM, Valnickova Z, Oury TD (2000) Immunolocalization of extracellular superoxide dismutase in mouse lung: Implications in pulmonary airway and vascular biology. Bchm Bphys Res Comm 275, 542-548.
    23. Thiels E, Urban NN, Gonzalez-Burgos GR, Kanterewicz BI, Barrionuevo G, Chu CT, Oury TD, Klann E. (2000) Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase. J Neurosci, 20, 7631-9.
    24. Nozik-Grayck E, Dieterle C, Piantadosi CA, Enghild JJ, Oury TD. (2000) Secretion of extracellular superoxide dismutase in neonatal lungs. Am J Physiol. 279, L977-84.
    25. Oury TD, Thakker K, Menache M, Chang LY, Crapo JD , Day BJ. (2001) Attenuation of bleomycin-induced pulmonary fibrosis by a catalytic antioxidant metalloporphyrin. Am. J. Resp. Cell Molec. Biol. 25, 164-69.
    26. Fattman CL, Chu CT, Kulich SM, Enghild JJ, Oury TD. (2001) Altered expression of extracellular superoxide dismutase in mouse lung after bleomycin treatment. Free Rad Biol Med 31, 1198-1207.
    27. Giles BL, Suliman H, Mamo LB, Piantadosi CA, Oury TD, Nozik-Grayck E. (2002) Prenatal hypoxia decreases lung extracellular superoxide dismutase expression and activity. Am J Physiol (Lung Cell Mol Physiol) 283, L549-54.
    28. McGirt MJ, Parra A, Sheng H, Higuchi Y, Oury TD, Laskowitz DT, Pearlstein RD, Warner DS. (2002) Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase. Stroke 33, 2317-23.
    29. Oury TD, Schaefer LM, Fattman CL, Choi A, Weck KE, Watkins SC. (2002) Depletion of pulmonary EC-SOD following exposure to hyperoxia. Am J Physiol (Lung Cell Mol Physiol) 283, L777-84.
    30. Zhu JH, Kulich SM, Oury TD, Chu CT. (2002) Cytoplasmic aggregates of phosphorylated extracellular signal regulated kinases in lewy body diseases. Am J. Pathol. 161, 2087-2098.
    31. Demchenko IT, Oury TD, Crapo JD, Piantadosi CA. (2002) Regulation of the brain’s vascular responses to oxygen. Circ Res 91,1031-1037.
    32. Fattman CL, Schaefer LM, Oury TD (2003) Extracellular superoxide dismutase in biology and medicine. Free Rad Biol Med 35, 236-256.
    33. Song R, Kubo M, Morse D, Zhou Z, Zhang X, Dauber JH, Fabisiak J, Alber SM, Watkins SC, Zuckerbraun BS, Otterbein LE, Ning W, Oury TD, Lee PJ, McCurry KR, Choi AMK. (2003) Carbon Monoxide Induces Cytoprotection in Rat Orthotopic Lung Transplantation via Anti-Inflammatory and Anti-Apoptotic Effects. Am J. Pathol. 163. 231-242.
    34. Fattman CL, Chang LY, Termin TA, Petersen LO, Enghild JJ, Oury TD. (2003) Enhanced bleomycin-induced pulmonary damage in mice lacking extracellular superoxide dismutase. Free Rad Biol Med. 35, 763-771.
    35. Hanford LE, Fattman CL, Schaefer LM, Enghild JJ, Valnickova Z, Oury TD (2003) Regulation of receptor for advanced glycation end products during bleomycin-induced lung injury. Am. J. Resp. Cell Molec. Biol, 29, S77-81.
    36. Petersen SV, Oury TD, Valnickova Z, Thøgersen IB, Højrup P, Crapo JD, Enghild JJ. (2003) The dual nature of human extracellular superoxide dismutase: one sequence and two structures. Proc Natl Acad Sci USA 100:13875-80.
    37. Sun D, Huang A, Yan EH,Wu Z, Yan C, Kaminski PM, Oury TD, Wolin MS, Kaley G. (2004) Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats. Am J Physiol Heart Circ Physiol, 286: H2249-2256
    38. Petersen SV, Oury TD, Ostergaard L, Valnickova Z, Wegrzyn J, Thogersen IB, Jacobsen C, Bowler RP, Fattman CL, Crapo JD, Enghild JJ: (2004) Extracellular Superoxide Dismutase (EC-SOD) Binds to Type I Collagen and Protects Against Oxidative Fragmentation. J Biol Chem. 279:13705-13710
    39. Olsen DA, Petersen SV, Oury TD, Valnickova Z, Thøgersen IB, Kristensen T, Bowler RP, Crapo JD, Enghild JJ. (2004) The Intracellular Proteolytic Processing of Extracellular Superoxide Dismutase (EC-SOD) is a Two Step Event. J Biol Chem. 279: 22152-22157
    40. Harju T, Kaarteenaho-Wiik R, Sirviö R, Pääkkö P, Crapo JD, Oury TD, Soini Y, Kinnula VL (2004) Manganese superoxide dismutase is increased in the airways of smoker's lung. Eur Resp J 24: 765-71.
    41. Tan RJ, Fattman CL, Watkins S, Oury TD (2004) Redistribution of pulmonary EC-SOD after exposure to asbestos. J Appl Physiol, 97: 2006-13.
    42. Petersen SV, Due, AV, Valnickova Z, Oury TD, Crapo JD, Enghild JJ. (2004) The structure of rabbit extracellular superoxide dismutase differs from the human protein. Biochemistry 44: 14275-81.
    43. Hanford LE, Valnickova Z, Petersen SV, Schaefer LM, Schaefer TM, Reinhart TA, Enghild JJ, Oury TD. (2004) Purification and characterization of mouse soluble receptor for advanced glycation end products (SRAGE). J Biol Chem. 279: 50019-24
    44. Zhou Z, Song R, Fattman CL, Feghali-Bostwick C, Oury TD, Benezra R, Choi AMK, Morse D. (2005) Carbon Monoxide Suppresses Bleomycin-Induced Lung Fibrosis via Anti-Proliferative and Anti-Fibrotic Effects. Am. J. Pathol. 166: 27-37.
    45. Petersen SV, Olsen DA, Kenney JM, Oury TD, Valnickova Z, Thogersen IB, Crapo JD, Enghild JJ (2005) The high concentration of Arg(213)-->Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities. Biochem J, 385: 427-432
    46. Callio J, Oury TD, Chu CT. (2005) Manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brains. J Biol Chem. 280: 18536-42
    47. Kinnula VL, Fattman CL, Tan RJ, Oury TD. (2005) Oxidative stress in pulmonary fibrosis: A possible role for redox-modulatory therapy Am J. Resp. Crit. Care Med. 172: 417-422
    48. Auten RL, O’Reilly MA, Oury TD, Nozik-Gracyk E, Whorton MH. (2006) Transgenic extracellular superoxide dismsutase (ec-sod) protects post-natal alveolar epithelial development during hyperoxia. Am J Physiol (Lung Cell Mol Physiol). 290: L32-40.
    49. Tan RJ, Lee JS, Manni ML, Fattman CL, Tobolewski JM, Zheng M, Kolls JK, Martin TR, Oury TD. (2006) Inflammatory cells as a source of airspace extracellular superoxide disumtase after pulmonary injury. Am. J. Resp. Cell Molec. Biol. 34: 226-232.
    50. Fattman CL, Tan RJ, Tobolewski JM, Oury TD. (2006) Extracellular superoxide disumtase protects mice from asbestos-induced lung injury. Free Rad Biol Med. In Press.
    51. Kinnula VL, Hodgson UA, Lakari EK, Tan RJ, Sormunen RT, Soini YM, Kakko SJ, Laitinen TH, Oury TD, Pääkkö PK. (2006) Extracellular superoxide dismutase has highly specific localization in idiopathic pulmonary fibrosis/usual interstitial pneumonia. Histopathology. In Press.
    52. Due AV, Petersen SV, Valnickova Z, Ostergaard L, Oury TD, Crapo JD, Enghild JJ. (2006) Human extracellular superoxide dismutase (EC-SOD) forms an octamer with high affinity for the extracellular matrix. FEBS letters. In Press.
    53. Hu D, Serrano F, Oury TD, Klann E. (2006) Aging-dependent alterations in synaptic plasticity and memory in mice that overexpress extracellular superoxide dismutase. J. Neurosci. In Press

    Reviews, invited published papers, proceedings of conference and symposia, monographs, books, and book chapters:


    1. Oury TD, Crapo JD, Piantadosi CA (1994) The nitric oxide synthesis inhibitor N-w-nitro-L-arginine decreases mortality, and delays seizure onset in mice exposed to hyperbaric oxygen, in Basic and Applied High Pressure Biology (Bennett PB, Marquis, RE, Ed) Vol 1, pp 437-444, University of Rochester Press, Rochester
    2. Zhang J, Oury TD, Tatro L, Piantadosi CA (1994) Cerebral amino acids and acute hyperbaric oxygen toxicity, in Basic and Applied High Pressure Biology (Bennett, PB and Marquis, RE, Ed) Vol 1, pp 431-436, University of Rochester Press, Rochester
    3. Oury TD, Chang L-Y, Day BJ, Slot J, Crapo JD (1995) Compartmentalization of radical reactions, in The Oxygen Paradox (Davies KJA, Ursini, F, Ed) pp 195-207, CLEUP University Press, Padova, Italy
    4. Oury TD, Day BJ, Crapo JD (1996) Extracellular superoxide dismutase: A regulator of nitric oxide bioavailability. Lab Invest 75, 617-636
    5. Day B, Oury TD, Crapo JD (1996) Interactions of superoxide dismutases with nitric oxide, in Vascular Endothelium: Responses to Injury (Catravas JD, Callow AD, Ryan US, Ed) pp 23-30
    6. Roggli VL, Oury TD, Moffatt JD (1997) Malignant mesothelioma in women, in Anatomic Pathology 1997 (Fechner RE, Rosen PP, Ed) Vol 2, pp 147-163, ASCP Press, Chicago
    7. Oury TD, Hammar SP, Roggli VL (1998) Ultrastructural characterization of mesotheliomas. Human Pathology 29, 1382-1392
    8. Oury TD, LeFurgey A, Roggli VL (1999) Microprobe analysis of renal stones, in Biomedical Applications of Microbrobe Analysis (Ingram P, Shelburne JD, Roggli VL, LeFurgey A, Ed). Academic Press, San Diego pp 291-313
    9. Oury TD, Roggli VL (2000) Interstitial fibrosis, predominantly mature, Chapter 5, in Diagnostic Pulmonary Pathology (Cagle, PT, Ed). Macell Decker, NY. pp 77-101.