NIKIFOROV LABORATORY
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Publications

1: Nikiforova MN, Chiosea SI, Nikiforov YE. MicroRNA Expression Profiles in Thyroid Tumors.
    Endocr Pathol. 2009 Summer;20(2):85-91. PubMed PMID: 19352602.


2: Nikiforov YE, Steward DL, Robinson-Smith TM, Haugen BR, Klopper JP, Zhu Z, Fagin JA, Falciglia M, Weber K,
    Nikiforova MN. Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules.
    J Clin Endocrinol Metab. 2009 Jun;94(6):2092-8. Epub 2009 Mar 24. PubMed PMID: 19318445.


3: Subramanian M, Pilli T, Bhattacharya P, Pacini F, Nikiforov YE, Kanteti PV, Prabhakar BS. Knockdown
    of IG20 gene expression renders thyroid cancer cells susceptible to apoptosis. J Clin Endocrinol Metab
.
    2009 Apr;94(4):1467-71. Epub 2009 Feb 3. PubMed PMID: 19190106; PubMed Central PMCID: PMC2682475.


4: Yip L, Seethala RR, Nikiforova MN, Nikiforov YE, Ogilvie JB, Carty SE, Yim JH. Loss of heterozygosity of selected tumor
    suppressor genes in parathyroid carcinoma. Surgery. 2008 Dec;144(6):949-55; discussion 954-5.
    PubMed PMID: 19041002.


5: Gandhi MS, Stringer JR, Nikiforova MN, Medvedovic M, Nikiforov YE. Gene position within chromosome
    territories correlates with their involvement in distinct rearrangement types in thyroid cancer cells.
Genes
     Chromosomes Cancer
. 2009 Mar;48(3):222-8. PubMed PMID: 19025793; PubMed Central PMCID: PMC2668203.


6: Nikiforov YE. Thyroid carcinoma: molecular pathways and therapeutic targets. Mod Pathol. 2008 May;21 Suppl 2:S37-43.
    Review. PubMed PMID: 18437172; PubMed Central PMCID: PMC2673022.


7: Filie AC, Asa SL, Geisinger KR, Logani S, Merino M, Nikiforov YE, Clark DP. Utilization of ancillary studies in thyroid fine
    needle aspirates: a synopsis of  the National Cancer Institute Thyroid Fine Needle Aspiration State of the Science
    Conference. Diagn Cytopathol. 2008 Jun;36(6):438-41. PubMed PMID: 18478603.


8: Nikiforova MN, Tseng GC, Steward D, Diorio D, Nikiforov YE. MicroRNA expression profiling of thyroid tumors: biological
    significance and diagnostic utility. J Clin Endocrinol Metab. 2008 May;93(5):1600-8. Epub 2008 Feb 12. PubMed
    PMID: 18270258; PubMed Central PMCID: PMC2386678.


9: Nikiforova MN, Nikiforov YE. Molecular genetics of thyroid cancer: implications for diagnosis, treatment
    and prognosis. Expert Rev Mol Diagn. 2008 Jan;8(1):83-95. Review. PubMed PMID: 18088233.


10: Volante M, Collini P, Nikiforov YE, Sakamoto A, Kakudo K, Katoh R, Lloyd RV, LiVolsi VA, Papotti M,
     Sobrinho-Simoes M, Bussolati G, Rosai J. Poorly differentiated thyroid carcinoma: the Turin proposal for
     the use of uniform diagnostic criteria and an algorithmic diagnostic approach. Am J Surg Pathol
.
     2007 Aug;31(8):1256-64. PubMed PMID: 17667551.


11: Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, Koenig RJ, Nikiforov YE. HOOK3-RET: a novel type of RET/PTC
     rearrangement in papillary thyroid carcinoma. Endocr Relat Cancer. 2007 Jun;14(2):445-52. PubMed PMID: 17639057.


12: Nikiforov YE. Radiation-induced thyroid cancer: what we have learned from chernobyl. Endocr Pathol.
     2006 Winter;17(4):307-17. Review. PubMed PMID: 17525478.


13: Ryder M, Nikiforov YE, Fagin JA. Follicular variant papillary thyroid carcinoma arising within an ovarian teratoma. Thyroid.
     2007 Feb;17(2):179-80. PubMed PMID: 17316122.


14: Ciampi R, Nikiforov YE. RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis.
      Endocrinology. 2007 Mar;148(3):936-41. Epub 2006 Aug 31. Review. PubMed PMID: 16946010.


15: Zhu Z, Ciampi R, Nikiforova MN, Gandhi M, Nikiforov YE. Prevalence of RET/PTC rearrangements in thyroid papillary
     carcinomas: effects of the detection methods and genetic heterogeneity. J Clin Endocrinol Metab. 2006 Sep;91(9):3603-10.
     Epub 2006 Jun 13. PubMed PMID: 16772343.


16: Nikiforov YE. RET/PTC Rearrangement--a link between Hashimoto's thyroiditis and thyroid cancer...or not. J Clin Endocrinol Metab.
     2006 Jun;91(6):2040-2. PubMed PMID: 16757533.


17: Saad AG, Kumar S, Ron E, Lubin JH, Stanek J, Bove KE, Nikiforov YE. Proliferative activity of human thyroid cells in various
     age groups and its correlation with the risk of thyroid cancer after radiation exposure. J Clin Endocrinol Metab.
     2006 Jul;91(7):2672-7. Epub 2006 May 2. PubMed PMID: 16670159.


18: Giordano TJ, Au AY, Kuick R, Thomas DG, Rhodes DR, Wilhelm KG Jr, Vinco M, Misek DE, Sanders D, Zhu Z, Ciampi R,
     Hanash S, Chinnaiyan A, Clifton-Bligh RJ, Robinson BG, Nikiforov YE, Koenig RJ. Delineation, functional validation, and
     bioinformatic evaluation of gene expression in thyroid follicular carcinomas with the PAX8-PPARG translocation.
     Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):1983-93.


19: Adeniran AJ, Zhu Z, Gandhi M, Steward DL, Fidler JP, Giordano TJ, Biddinger PW, Nikiforov YE.
     Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic
     characteristics of thyroid papillary carcinomas. Am J Surg Pathol. 2006 Feb;30(2):216-22. PubMed PMID:
     16434896.


20: Gandhi M, Medvedovic M, Stringer JR, Nikiforov YE. Interphase chromosome folding determines spatial proximity of genes
     participating in carcinogenic RET/PTC rearrangements. Oncogene. 2006 Apr 13;25(16):2360-6.
     PubMed PMID: 16331264.


21: Ciampi R, Nikiforov YE. Alterations of the BRAF gene in thyroid tumors. Endocr Pathol.
     2005 Fall;16(3):163-72. Review. PubMed PMID: 16299399.


22: Nikiforov YE. The molecular pathways induced by radiation and leading to thyroid carcinogenesis. Cancer
     Treat Res
. 2004;122:191-206. Review. PubMed PMID: 16209046.


23: Ciampi R, Zhu Z, Nikiforov YE. BRAF copy number gains in thyroid tumors detected by fluorescence in situ
     hybridization. Endocr Pathol. 2005 Summer;16(2):99-105. PubMed PMID: 16199894.


24: Giordano TJ, Kuick R, Thomas DG, Misek DE, Vinco M, Sanders D, Zhu Z, Ciampi R, Roh M, Shedden K, Gauger P,
     Doherty G, Thompson NW, Hanash S, Koenig RJ,Nikiforov YE. Molecular classification of papillary thyroid carcinoma: distinct
     BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis. Oncogene.
     2005 Oct 6;24(44):6646-56. PubMed PMID: 16007166.


25: Knauf JA, Ma X, Smith EP, Zhang L, Mitsutake N, Liao XH, Refetoff S, Nikiforov YE, Fagin JA. Targeted expression
     of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.
     Cancer Res. 2005 May 15;65(10):4238-45. PubMed PMID: 15899815.


26: Salvatore G, Chiappetta G, Nikiforov YE, Decaussin-Petrucci M, Fusco A, Carney JA, Santoro M. Molecular
     profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and
     absence of B-raf and N-ras point mutations. Eur J Cancer. 2005 Mar;41(5):816-21. PubMed PMID: 15763659.


27: Ciampi R, Knauf JA, Rabes HM, Fagin JA, Nikiforov YE. BRAF kinase activation via chromosomal rearrangement in
     radiation-induced and sporadic thyroid cancer. Cell Cycle. 2005 Apr;4(4):547-8. Epub 2005 Apr 24. Review.
     PubMed PMID: 15753649.


28: Nikiforova MN, Groen P, Mutema G, Nikiforov YE, Witte D. Detection of SYT-SSX rearrangements in synovial sarcomas by
     real-time one-step RT-PCR. Pediatr Dev Pathol. 2005 Mar-Apr;8(2):162-7. Epub 2005 Mar 8. PubMed PMID: 15747098.


29: Nikiforov YE. Editorial: anaplastic carcinoma of the thyroid--will aurora B light a path for treatment? J Clin Endocrinol Metab.
     2005 Feb;90(2):1243-5. PubMed PMID: 15699543.


30: Nikiforov YE. Genetic alterations involved in the transition from well-differentiated to poorly differentiated
     and anaplastic thyroid carcinomas. Endocr Pathol. 2004 Winter;15(4):319-27. Review. PubMed PMID: 15681856.


31: Caudill CM, Zhu Z, Ciampi R, Stringer JR, Nikiforov YE. Dose-dependent generation of RET/PTC in human thyroid cells after
     in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiation.
     J Clin Endocrinol Metab. 2005 Apr;90(4):2364-9. Epub 2005 Jan 25. PubMed PMID: 15671095.


32: Ciampi R, Knauf JA, Kerler R, Gandhi M, Zhu Z, Nikiforova MN, Rabes HM, Fagin JA, Nikiforov YE. Oncogenic AKAP9-BRAF
     fusion is a novel mechanism of MAPK pathway activation in thyroid cancer. J Clin Invest. 2005 Jan;115(1):94-101.
     PubMed PMID: 15630448; PubMed Central PMCID: PMC539203.


33: Salvatore G, Giannini R, Faviana P, Caleo A, Migliaccio I, Fagin JA, Nikiforov YE, Troncone G, Palombini L, Basolo F,
     Santoro M. Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of
     papillary thyroid carcinoma. J Clin Endocrinol Metab. 2004 Oct;89(10):5175-80. PubMed PMID: 15472223.


34: Kim J, Nikiforov YE, Moulton JS, Lowy AM. Multiple focal nodular hyperplasia of the liver in a 21-year-old woman.
     J Gastrointest Surg. 2004 Jul-Aug;8(5):591-5. PubMed PMID: 15239996.


35: Saad A, Falciglia M, Steward DL, Nikiforov YE. Amiodarone-induced thyrotoxicosis and thyroid cancer: clinical, immunohistochemical,
     and molecular genetic studies of a case and review of the literature. Arch Pathol Lab Med. 2004 Jul;128(7):807-10.
     Review. PubMed PMID: 15214815.


36: Vitagliano D, Carlomagno F, Motti ML, Viglietto G, Nikiforov YE, Nikiforova MN, Hershman JM, Ryan AJ, Fusco A, Melillo RM,
     Santoro M. Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells.
     Cancer Res. 2004 Jun 1;64(11):3823-9. PubMed PMID: 15172989.


37: Nikiforova MN, Ciampi R, Salvatore G, Santoro M, Gandhi M, Knauf JA, Thomas GA, Jeremiah S, Bogdanova TI, Tronko MD,
     Fagin JA, Nikiforov YE. Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic
     papillary carcinomas. Cancer Lett. 2004 Jun 8;209(1):1-6. PubMed PMID: 15145515.


38: Kimura ET, Vanvooren V, van Sande J, Nikiforov YE, Fagin JA. Autonomously functioning thyroid nodules
     are not associated with BRAF mutations. Clin Endocrinol (Oxf). 2004 Mar;60(3):394-6.
     PubMed PMID: 15009007.


39: Nikiforova MN, Kimura ET, Gandhi M, Biddinger PW, Knauf JA, Basolo F, Zhu Z, Giannini R, Salvatore G, Fusco A, Santoro M,
     Fagin JA, Nikiforov YE. BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated
     carcinomas arising from papillary carcinomas. J Clin Endocrinol Metab. 2003 Nov;88(11):5399-404. PubMed PMID: 14602780.


40: Zhu Z, Gandhi M, Nikiforova MN, Fischer AH, Nikiforov YE. Molecular profile and clinical-pathologic features of the follicular variant
     of papillary thyroid carcinoma. An unusually high prevalence of ras mutations. Am J Clin Pathol. 2003
     Jul;120(1):71-7. PubMed PMID: 12866375.


41: Nikiforov YE. Spatial positioning of RET and H4 following radiation exposure leads to tumor development.
      Scientific World Journal. 2001 May 1;1:186-7. Review. PubMed PMID: 12805663.


42: Nikiforova MN, Lynch RA, Biddinger PW, Alexander EK, Dorn GW 2nd, Tallini G, Kroll TG, Nikiforov YE. RAS point mutations and
     PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.
     J Clin Endocrinol Metab. 2003 May;88(5):2318-26. PubMed PMID: 12727991.


43: Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA. High prevalence of BRAF mutations in thyroid cancer: genetic
     evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res.
     2003 Apr 1;63(7):1454-7. PubMed PMID: 12670889.


44: Nikiforova MN, Biddinger PW, Caudill CM, Kroll TG, Nikiforov YE. PAX8-PPARgamma rearrangement in thyroid
     tumors: RT-PCR and immunohistochemical analyses. Am J Surg Pathol. 2002 Aug;26(8):1016-23.
     PubMed PMID: 12170088.


45: Nikiforov YE. RET/PTC rearrangement in thyroid tumors. Endocr Pathol. 2002 Spring;13(1):3-16. Review.
     PubMed PMID: 12114746.


46: Knauf JA, Ward LS, Nikiforov YE, Nikiforova M, Puxeddu E, Medvedovic M, Liron T, Mochly-Rosen D, Fagin JA.
     Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.
J Clin
      Endocrinol Metab
. 2002 May;87(5):2150-9. PubMed PMID: 11994357.


47: Nikiforova MN, Caudill CM, Biddinger P, Nikiforov YE. Prevalence of RET/PTC rearrangements in Hashimoto's
     thyroiditis and papillary thyroid carcinomas. Int J Surg Pathol. 2002 Jan;10(1):15-22. PubMed PMID: 11927965.


48: Basolo F, Giannini R, Toniolo A, Casalone R, Nikiforova M, Pacini F, Elisei R, Miccoli P, Berti P, Faviana P, Fiore L, Monaco C,
     Pierantoni GM, Fedele M, Nikiforov YE, Santoro M, Fusco A. Establishment of a non-tumorigenic papillary thyroid cell line (FB-2)
     carrying the RET/PTC1 rearrangement. Int J Cancer. 2002  Feb 10;97(5):608-14. PubMed PMID: 11807785.


49: Radivoyevitch T, Sachs RK, Nikiforov YE, Nikiforova MN, Little MP. On target cell numbers in radiation-induced H4-RET
     mediated papillary thyroid cancer. Radiat Environ Biophys. 2001 Sep;40(3):191-7. PubMed PMID: 11783847.


50: Nikiforov YE, Erickson LA, Nikiforova MN, Caudill CM, Lloyd RV. Solid variant of papillary thyroid carcinoma: incidence,
     clinical-pathologic characteristics, molecular analysis, and biologic behavior. Am J Surg Pathol. 2001
     Dec;25(12):1478-84. PubMed PMID: 11717536.


51: Nikiforova MN, Stringer JR, Blough R, Medvedovic M, Fagin JA, Nikiforov YE. Proximity of chromosomal loci that participate in
     radiation-induced rearrangements in human cells. Science. 2000 Oct 6;290(5489):138-41. PubMed PMID: 11021799.


52: Bejarano PA, Nikiforov YE, Swenson ES, Biddinger PW. Thyroid transcription factor-1, thyroglobulin,
     cytokeratin 7, and cytokeratin 20 in thyroid neoplasms. Appl Immunohistochem Mol Morphol. 2000 Sep;8(3):189-94.
     PubMed PMID: 10981870.


53: Patel A, Fenton C, Ramirez R, Dinauer CA, Tuttle RM, Nikiforov YE, Gary FL. Tyrosine kinase expression is
     increased in papillary thyroid carcinoma of children and young adults. Front Biosci. 2000 Mar 1;5:A1-9.
     PubMed PMID: 10702379.


54: Nikiforov YE, Koshoffer A, Nikiforova M, Stringer J, Fagin JA. Chromosomal breakpoint positions suggest a direct role for radiation in
     inducing illegitimate recombination between the ELE1 and RET genes in radiation-induced thyroid carcinomas. Oncogene.
     1999 Nov 4;18(46):6330-4. PubMed PMID: 10597232.


55: Nikiforova MN, Nikiforov YE, Biddinger P, Gnepp DR, Grosembacher LA, Wajchenberg BL, Fagin JA, Cohen RM. Frequent loss of
     heterozygosity at chromosome 3p14.2-3p21 in human pancreatic islet cell tumours. Clin Endocrinol (Oxf). 1999 Jul;51(1):27-33.
     PubMed PMID: 10468962.


56: Nikiforov YE, Gnepp DR. Pathomorphology of thyroid gland lesions associated with radiation exposure: the
     Chernobyl experience and review of the literature. Adv Anat Pathol. 1999 Mar;6(2):78-91. Review.
     PubMed PMID: 10331070.


57: Evans HA, Shaughnessy EA, Nikiforov YE. Infiltrating ductal carcinoma of the breast with osseous metaplasia: imaging findings with
     pathologic correlation. AJR Am J Roentgenol. 1999 May;172(5):1420-2. PubMed PMID: 10227530.


58: Nikiforov YE, Nikiforova M, Fagin JA. Prevalence of minisatellite and microsatellite instability in radiation-
     induced post-Chernobyl pediatric thyroid carcinomas. Oncogene. 1998 Oct 15;17(15):1983-8.
     PubMed PMID: 9788442.


59: Motomura T, Nikiforov YE, Namba H, Ashizawa K, Nagataki S, Yamashita S, Fagin JA. ret rearrangements in
     Japanese pediatric and adult papillary thyroid cancers. Thyroid. 1998 Jun;8(6):485-9. PubMed PMID: 9669285.


60: Wang J, Niu W, Witte DP, Chernausek SD, Nikiforov YE, Clemens TL, Sharifi B,  Strauch AR, Fagin JA. Overexpression of insulin-like
     growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4
     fusion gene induces smooth muscle hypoplasia. Endocrinology. 1998 May;139(5):2605-14. PubMed PMID: 9564877.


61: Nikiforov YE, Rowland JM, Bove KE, Monforte-Munoz H, Fagin JA. Distinct pattern of ret oncogene rearrangements in morphological
     variants of radiation-induced and sporadic thyroid papillary carcinomas in children. Cancer Res. 1997 May 1;57(9):1690-4.
     PubMed PMID: 9135009.


62: Nikiforov YE, Fagin JA. Risk factors for thyroid cancer. Trends Endocrinol Metab. 1997 Jan-Feb;8(1):20-5.
     PubMed PMID: 18406782.


63: Nikiforov YE, Nikiforova MN, Gnepp DR, Fagin JA. Prevalence of mutations of ras and p53 in benign and
     malignant thyroid tumors from children exposed to radiation after the Chernobyl nuclear accident. Oncogene.
     1996 Aug 15;13(4):687-93. PubMed PMID: 8761289.


64: Nikiforov YE, Heffess CS, Korzenko AV, Fagin JA, Gnepp DR. Characteristics of follicular tumors and
     nonneoplastic thyroid lesions in children and adolescents exposed to radiation as a result of the Chernobyl disaster.
      Cancer. 1995 Sep 1;76(5):900-9. PubMed PMID: 8625196.



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