Wells' Lab - Latha Satish

Scaife 711
Department of Pathology
University of Pittsburgh
Pittsburgh, PA 15261
412-624-0613

lsatish@pitt.edu

Education

Institution Degree Conferred Field of study
University of Madras BS 1990 Zoology
University of Madras MS 1992 Zoology
University of Madras M. Phil. 1993 Zoology
University of Madras  Ph.D. 1998 Zoology and Biotechnology

Publications

  1. Action of trypsin:chymotrypsin (Chymoral forte D.S.) preparation on acute phase proteins following burn injury in humans. B. Latha, M. Ramakrishnan, V.Jayaraman & MaryBabu. Burns. V. 23, S.No.1, pp. S3-S7, 1997.
  2. Serum enzymatic changes modulated using trypsin:chymotrypsin preparation during burn wounds in humans. B.Latha, M.Ramakrishnan, V.Jayaraman & MaryBabu Burns. V.7/8, pp. 560-564, 1997.
  3. Efficacy of trypsin:chymotrypsin preparation in the reduction of oxidative damage during burn injury in humans. B.Latha, M.Ramakrishnan, V.Jayaraman & MaryBabu. Burns. V.24, pp.532-538, 1998.
  4. Physicochemical properties of extracellular matrix proteins in postburn human granulation tissue. B.Latha, M.Ramakrishnan, V.Jayaraman & MaryBabu. Comparative Biochemistry and Physiology. Part B V.124 pp.241-249, 1999.
  5. The involvement of free radicals in burn injury: a review. B.Latha and Mary Babu. Burns. V. 27 pp. 309-317, 2001.
  6. ELR-negative CXC chemokine IP-9 as a mediator of epidermal-dermal communication during wound repair Latha Satish, Dorne Yager and Alan Wells. Manuscript in press - Journal of Investigative Dermatology

Abstracts

Modulation of acute phase reactions during burn injury in humans by trypsin:chymotrypsin preparation. B.Latha & MaryBabu.
At the 65th Annual meeting of the society of biological chemists (INDIA), Bangalore. Nov.20-Nov.23, 1994 pp.38.

Action of chymotrypsin on acute phase reactants in reduction of burn oedema. M. Ramakrsihnan, B.Latha, V.Jayaraman & MaryBabu.
At the Vth national conference of Burn Association of India. BAICON'95, Jaipur (INDIA)Nov.26-28, 1995. pp.76.

Effect of chymoral forte therapy during burn injury in man. B.Latha, V.Jayaraman, M.Ramakrishnan & MaryBabu.
At the 64th Annual meeting of the society of biological chemists, Lucknow (INDIA) Oct. 6-8, 1995. P.61

Action of chymotrypsin on acute phase reactants in reduction of burn oedema. M.Ramakrishnan & B.Latha.
Presented in second-Asian Pacific Burns conference held at Hongkong from 8-11 Feb. 1996. pp. 148.

Action of chymoral forte DS on acute phase reactants in reducing burn oedema. B. Latha.
Presented at the Vth National Academy of Burns Conference (NABICON) held at Madras from Jan 31-Feb 2, 1997.

aBeneficial effects of trypsin:chymotrypsin (Chymoral forte DS) preparation eliciting antioxidant property during burn injury in humans. B. Latha.
Presented at the VIth National Academy of Burns Conference (NABICON) held at Delhi from May 1- 3, 1998.

Beneficial effects of trypsin:chymotrypsin preparation during burn injury in humans. M.Ramakrishnan, B.Latha, V.Jayaraman & MaryBabu.
Presented in 10th Congress of the International Society for Burn Injuries held at Jerusalem, Israel, Nov. 1-5, 1998 p.67.

Modulatory effects of trypsin:chymotrypsin combination during inflammation in human burns. B.Latha & MaryBabu.
Presented in 1999 Gordon Research Conference on WOUNDREPAIR held at New Hampshire, USA, June 13-18, 1999.

The CXC chemokine IP-9 plays a dual role in controlling cell motility. Latha Satish, H. Shiraha, A. Wells.
Presented in wound healing educational symposium held at Ontario, Canada, June 4-6, 2000.

IP-9 as a mediator of dermal and epidermal communication during wound repair. Latha Satish.
Oral presentation in the wound healing educational symposium held at Albuquerque, New Mexico, USA, May 16-18, 2001.

Modulation of fibroblasts and keratinocytes migratory responses by ELR-negative CXC chemokine IP-9 through differential activation of calpain isoforms. Latha Satish.
Oral presentaion in the 12th Annual Pathology Research presentation held at Universtity of Pittsburgh, Department of Pathology, Pittsburgh, July 13-15, 2001.

IP-9 induced cell migration in keratinocytes is effected through Mu-calpain isoform. Latha Satish, A. Glading, H.Shiraha, D.Yager , Alan Wells
Presented in American Society of Cell Biology, Washington DC, USA, December 8-12, 2001.

Utilization of G-proteins during IP-9 induced cell migration in fibroblasts and keratinocytes. Latha Satish
Oral presentation in the wound healing educational symposium to be held in Baltimore, Maryland, USA, May-28-June 3, 2002.

IP-9 as a mediator of epidermal and dermal communication during wound repair. Latha Satish and Alan Wells
Presented at 13th Annual Pathology Research presentation held at Universtity of Pittsburgh, Department of Pathology, Pittsburgh, July 13-15, 2002.

Opposite motility responses of keratinocytes and fibroblasts to CXC-chemokine IP-9 is due to differential effects on calpain isoforms. Latha Satish and Alan Wells
Accepted for Presentation in American Society of Cell Biology, San Francisco, CA, USA, December 14-18, 2002.

Honors and Awards

  • Awarded Senior Research Fellowship from Council of Scientific and Industrial Research, Government of India.
  • Best Paper Award for the presentation of the paper on "Acute Phase Proteins" at the Vth National Academy of Burns Conference, Chennai, India.
  • First Place for the Paper presented at the 13th Annual Pathology Research Day held at University of Pittsburgh, Department of Pathology, July 13-15, 2002.
  • Awarded PPRTP funding for Post Docs from Department of Pathology , UPMC 2002-2003.