Wells' Lab - Publications
Cell Biology - biochemistry and biophysics
P Chen, K Gupta, A Wells (1994). Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis. Journal of Cell Biology 124, 547-555.Link to Abstract
P Chen, H Xie, MC Sekar, K Gupta, A Wells (1994). Epidermal growth factor
receptor- mediated cell motility: Phospholipase C activity is required, but MAP
kinase activity is not sufficient for induced cell motility. Journal of Cell
Biology 127, 847-857.
Link
to Abstract
M Zhang, RK Singh, M-H Wang, A Wells, GP Siegal (1996). Epidermal growth
factor modulates cell attachment to hyaluronic acid by the cell surface
glycoprotein CD44. Clinical and Experimental Metastasis 14, 268-276.
Link
to Abstract
M Zhang, M-H Wang, RK Singh, A Wells, GP Siegal (1997). Epidermal growth
factor induces CD44 expression through a novel regulatory element in mouse
fibroblasts. Journal of Biological Chemistry 272, 14139-14146.
Link
to Abstract
P Chen, J Murphy-Ullrich, A Wells (1996). A role for gelsolin in actuating
EGF receptor-mediated cell motility. Journal of Cell Biology 134,
689-698.
Link
to Abstract
H Xie, MA Pallero, K Gupta, MF Ware, P Chang, W Witke, DJ Kwiatkowski, DA
Lauffenburger, J Murphy-Ullrich, A Wells (1998). EGF receptor regulation of
cell- substratum interactions: EGF-induced disassembly of focal adhesions does
not require the motility-associated PLCy signaling pathway. Journal of
Cell Science 111, 616-625.
Link
to Abstract
A Wells, K Gupta, P Chang, S Swindle, A Glading, H Shiraha
(1998). Epidermal growth factor receptor-mediated motility in
fibroblasts. Microscopy Research and Technique 43, 395-411.
Link
to Abstract
G Maheshwari, A Wells, LG Griffith, DA Lauffenburger
(1999). Crosstalk between EGF and fibronectin receptors affects fibroblast
migration and underlying biophysical processes. Biophysical Journal 76,
2814-2823.
Link
to Abstract
A Glading, P Chang, DA Lauffenburger, A Wells (2000). EGF receptor
activation of calpain is required for fibroblast motility and occurs via and
ERK/MAP kinase signaling pathway. Journal of Biological Chemistry 275,
2390-2398.
Link
to Abstract
U Marti, A Wells (2000). The nuclear accumulation of a variant
epidermal growth factor receptor (EGFR) lacking the transmembrane domain
requires co-expression of a full length EGFR. Molecular Cell Biology
Research Communications 3, 8-14.
Link
to Abstract
MA Barbieri, R Roberts, A Gumusboga, H Highfield, C
Alvarez-Dominguez, A Wells, PD Stahl (2000). Signal transduction and membrane
trafficking: activation of MAP kinase and endocytosis by the EGF receptor
requires Rab 5a. Journal of Cell Biology 151, 539-550.
Link
to Abstract
TB Deb, L Su, L Wong, E Bonvini, A Wells, M David, GR
Johnson (2001). EGF receptor kinase-independent signaling by EGF. Journal of
Biological Chemistry 276, 1554-15560.
Link
to Abstract
A Glading, F Uberall, SM Keyse, DA Lauffenburger, A Wells
(2001). Membrane proximal ERK signaling is required for M-calpain activation
downstream of EGF receptor signaling. Journal of Biological Chemistry 276,
23341-23348.
Link
to Abstract
Pathology - tumor progression
BW Hughes, A Wells, Z Bebok, VK Gadi, RI Garver, WB Parker, EJ Sorscher (1995). Sensitization and high level bystander killing of melanoma cells using the human tyrosinase promoter to express the E. coli purine nucleoside phosphorylase gene. Cancer Research 55, 3339-3345.Link to Abstract
H Xie, T Turner, M-H Wang, RK Singh, GP Siegal, A Wells (1995). Prostate
carcinoma cell, DU-145, invasiveness in vitro is modulated by EGF receptor
signaling. Clinical and Experimental Metastasis 13, 407-419.
Link
to Abstract
T Turner, P Chen, LJ Goodly, A Wells (1996). EGF receptor signaling enhances
in vivo invasiveness of DU-145 human prostate carcinoma cells. Clinical and
Experimental Metastasis 14, 409-418.
Link
to Abstract
WB Parker, SA King, PW Allan, LL Bennett, JA Secrist, JA Montgomery, KS
Gilbert, WR Waud, A Wells, GY Gillespie, EJ Sorscher (1997). In vivo gene
therapy of cancer using E. coli purine nucleoside phosphorylase. Human Gene
Therapy, 8 1637-1644.
Link
to Abstract
RW Hardy, NSMD Wickramasinghe, A Wells (1997). Fatty acids and breast cancer
cell proliferation. Advances in Experimental Medicine and Biology, 422,
57-69.
Link
to Abstract
T Turner, M Van Epps-Fung, J Kassis, A Wells (1997). Molecular inhibition of
PLCg signaling abrogates DU-145 prostate tumor cell invasion. Clinical Cancer
Research 3, 2275-2282.
Link
to Abstract
T Turner, W Roberts, G R Pettit, A Wells, A Kraft (1998). Treatment of human
prostate cancer with Dolastatin 10, a peptide isolated from a marine shell-less
mollusk. Prostate 34, 175-181.
Link
to Abstract
H Qin, JD Moellinger, A Wells, LJ Windsor, Y Sun, EN
Benveniste (1998). Transcriptional suppression of matrix metalloproteinase-2
gene expression in human astroglioma cells by TNF-a and
IFN-g. Journal of Immunology 161,
6664-6673.
Link
to Abstract
S Khoshyomn, PL Penar, J Rossi, A Bhushan, A Wells, TR
Tritton, DL Abamson (1999). Inhibition of PLC gamma-1 activation blocks
glioma cell motility and invasion of fetal rat brain aggregates. Neurosurgery
44, 568-577.
Link
to Abstract
JA Secrist, WB Parker, PW Allan, LL Bennett, WR Waud, JW
Truss, AT Fowler, JA Montgomery, SE Ealick, AH Wells, GY Gillespie, VKGadi, EJ
Sorscher (1999). Gene therapy of cancer: activation of nucleoside prodrugs
with E. coli purine nucleoside phosphorylase. Nucleosides and Nucleotides 18,
745-757.
Link
to Abstract
J Kassis, J Moellinger, H Lo, N Greenberg, H Kim, A Wells
(1999). A role for PLCg-mediated signaling in
tumor cell invasion. Clinical Cancer Research 5, 2251-2260.
Link
to Abstract
A Wells (2000). Tumor invasion: role of growth
factor-induced cell motility Advances in Cancer Research 78,
31-101.
Link
to Abstract
J Kassis, DA Lauffenburger, T Turner, A Wells (2001).
Tumor invasion as dysregulated cell motility. Seminars in Cancer Biology 11,
105-119.
Link
to Abstract
A Wells (2000). The epidermal growth factor receptor ? a
new target in cancer therapy. Signal 1, 4-10.
EJ Manos, M Kim, J Kassis, B Chang, A Wells, DA Jones
(2001). Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase
C-gamma regulated gene negatively associated with prostate tumor invasion.
Oncogene 20, 2781-2790.
Link
to Abstract
Physiology - wound healing and organ morphogenesis
MF Ware, A Wells, DA Lauffenburger (1998). Epidermal growth factor increases fibroblast migration speed but decreases directional persistence in a substratum-dependent manner. Journal of Cell Science 111, 2423-2432.Link to Abstract
H Shiraha, A Glading, K Gupta, A Wells (1999).
Chemokine transmodulation of EGF Receptor signaling: IP-10 inhibits
motility by decreasing EGF-induced calpain activity. Journal of Cell
Biology 146, 243-253.
Link
to Abstract
H Kim, T Turner, J Kassis, A Wells (1999). EGF
receptor signaling in prostate development. Histology and Histopathology
14, 1175-1182.
Link
to Abstract
G Maheshwari, G Brown, DA Lauffenburger, A Wells, LG Griffith (2000).
Cell adhesion and motility depend on nanoscale RGD clustering. Journal of
Cell Science 113, 1677-1686.
Link
to Abstract
H Shiraha, K Gupta, KA Drabik, A Wells (2000). Preferential loss of
epidermal growth factor receptor results in reduced responsiveness in aging
dermal fibroblasts. Journal of Biological Chemistry 275,
19343-19351.
Link
to Abstract
A Wells, MF Ware, FD Allen, DA Lauffenburger (1999). Shapping up for
shipping out: PLC signaling of morphology changes in EGF-stimulated fibroblast
migration. Cell Motility and the Cytoskeleton 44, 227-233.
Link
to Abstract
CS Swindel, KT Tran, TD Johnson, P Banerjee, AM Mayes, LG Griffith, A Wells (2001). Direct activation of the epidermal growth factor receptor by EGF-like repeats of human tenascin-C. Journal of Cell Biology, in press.
DA Lauffenburger, A Wells (2001).
Getting a grip: new insights for cell adhesion and traction. Nature Cell Biology
3, E110-112.
Link
to Abstract
Signaling and metabolic consequences
DA Lauffenburger, L Chu, A French, F Oehrtman, C Reddy, B Will, A Wells, HS Wiley (1996). Engineering dynamics of growth factors and other therapeutic ligands. Biotechnology and Bioengineering 52, 61-80.Link to Abstract
P Chen, H Xie, A Wells (1996). Mitogenic signaling from the EGF receptor is
attenuated by a phospholipase C-g/protein kinase C feedback mechanism. Molecular
Biology of the Cell 7, 871-881.
Link
to Abstract
M David, L Wong, R Flavell, SA Thompson, A Wells, AC Larner, GR Johnson
(1996).
STAT activation by EGF and amphiregulin: requirement for the EGF
receptor
kinase, but not for tyrosine phosphorylation sites or JAK1. Journal
of Biological
Chemistry 271, 9185-9188.
Link
to Abstract
C Reddy, A Wells, DA Lauffenburger (1996). Receptor-mediated effects on
ligand availability influence relative mitogenic potencies of epidermal growth
factor and transforming growth factor a. Journal of Cellular Physiology 166,
512-522.
Link
to Abstract
CC Reddy, SK Niyogi, A Wells, HS Wiley, DA Lauffenburger (1996).
Re-engineering epidermal growth factor for enhanced potency. Nature
Biotechnology 14, 1696-1699.
Link
to Abstract
CC Reddy, A Wells, DA Lauffenburger (1994). Proliferative response of
fibroblasts expressing internalization-deficient EGF receptors is altered via
differential EGF depletion effects. Biotechnology Progress 10,
377-384.
Link
to Abstract
R Hardy, KB Gupta, JM. McDonald, J Williford, A Wells (1995) EGF receptor
carboxy- terminal domains are required for EGF-induced glucose transport in
transgenic 3T3- L1 adipocytes. Endocrinology 136, 431-439.
Link
to Abstract
M Van Epps-Fung, K Gupta, J Williford, RW Hardy, A Wells (1996). Epidermal
growth factor induces glucose storage in transgenic 3T3-L1 adipocytes
overexpressing epidermal growth factor receptors. Diabetes 45,
1619-1625.
Link
to Abstract
M Van Epps-Fung, J Williford, A Wells, RW Hardy (1997). Fatty acid-induced
insulin resistance in adipocytes. Endocrinology, 138, 4338-4345.
Link
to Abstract
M Van Epps-Fung, K Gupta, R Hardy, A Wells (1997). A role for phospholipase C
activity in GLUT4-mediated glucose transport. Endocrinology, 138,
5170-5175.
Link
to Abstract
CC Reddy, A Wells, DA Lauffenburger (1998). Comparative mitogenic potencies
of EGF and TGFa depend on receptor limitation versus ligand-limitation. Medical
and Biological Engineering and Computation 36, 499-507.
Link
to Abstract
L Wong, TB Debs, A Wells, SA Thompson, GR Johnson (1999). A
differential requirement for the COOH-terminal region of the EGF receptor in
Amphiregulin and EGF mitogenic signaling. Journal of Biological Chemistry 274,
8900-8909.
Link
to Abstract
JM Haugh, A Wells, HS Wiley, DA Lauffenburger (1999). Effect of
epidermal growth factor receptor internalization on regulation of the
phospholipase C-g signaling pathway. Journal of
Biological Chemistry 274, 8958-8965.
Link
to Abstract
A Wells (1999). Molecule in Focus: EGF receptor.
International Journal of Biochemistry and Cell Biology
31,637-643.
Link
to Abstract
JM Haugh, AC Huang, HS Wiley, A Wells, DA Lauffenburger (1999).
Participation of internalized epidermal growth factor receptors in the
activation of p21ras. Journal of Biological Chemistry 274,
34350-34360.
Link
to Abstract
JM Haugh, A Wells, DA Lauffenburger (2000). Mathematical
modeling of epidermal growth factor receptor signaling through the Phospholipase
C pathway: mechanistics insights and predictions for molecular interventions.
Biotechnology and Bioengineering 70, 225-238.
Link
to Abstract
RJ Botelho, M Teruel, R Dierckman, R Anderson, A Wells, JD
York, T Meyer, S Grinstein (2000). Localized changes in
phosphatidylinositol-4,5-bisphosphate metabolism during Fcg receptor-mediated
phagocytosis. Journal of Cell Biology 151, 1353-1367.
Link
to Abstract
A Wells (2001). The EGF receptor signaling system: a model for growth factor receptor signaling. Hormone Signaling, in press.