P Chen, H Xie, MC Sekar, K Gupta, A Wells (1994). Epidermal growth factor
receptor- mediated cell motility: Phospholipase C activity is required, but MAP
kinase activity is not sufficient for induced cell motility. Journal of Cell
Biology 127, 847-857.
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to Cell Biology - biochemistry and biophysics
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to Abstract
M Zhang, RK Singh, M-H Wang, A Wells, GP Siegal (1996). Epidermal growth
factor modulates cell attachment to hyaluronic acid by the cell surface
glycoprotein CD44. Clinical and Experimental Metastasis 14, 268-276.
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to Cell Biology - biochemistry and biophysics
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to Abstract
M Zhang, M-H Wang, RK Singh, A Wells, GP Siegal (1997). Epidermal growth
factor induces CD44 expression through a novel regulatory element in mouse
fibroblasts. Journal of Biological Chemistry 272, 14139-14146.
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to Cell Biology - biochemistry and biophysics
Link
to Abstract
P Chen, J Murphy-Ullrich, A Wells (1996). A role for gelsolin in actuating
EGF receptor-mediated cell motility. Journal of Cell Biology 134,
689-698.
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to Cell Biology - biochemistry and biophysics
Link
to Abstract
H Xie, MA Pallero, K Gupta, MF Ware, P Chang, W Witke, DJ Kwiatkowski, DA
Lauffenburger, J Murphy-Ullrich, A Wells (1998). EGF receptor regulation of
cell- substratum interactions: EGF-induced disassembly of focal adhesions does
not require the motility-associated PLCy signaling pathway. Journal of
Cell Science 111, 616-625.
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to Cell Biology - biochemistry and biophysics
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to Abstract
A Wells, K Gupta, P Chang, S Swindle, A Glading, H Shiraha
(1998). Epidermal growth factor receptor-mediated motility in
fibroblasts. Microscopy Research and Technique 43, 395-411.
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to Cell Biology - biochemistry and biophysics
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to Abstract
G Maheshwari, A Wells, LG Griffith, DA Lauffenburger
(1999). Crosstalk between EGF and fibronectin receptors affects fibroblast
migration and underlying biophysical processes. Biophysical Journal 76,
2814-2823.
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to Cell Biology - biochemistry and biophysics
Link
to Abstract
A Glading, P Chang, DA Lauffenburger, A Wells (2000). EGF receptor
activation of calpain is required for fibroblast motility and occurs via and
ERK/MAP kinase signaling pathway. Journal of Biological Chemistry 275,
2390-2398.
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to Cell Biology - biochemistry and biophysics
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to Abstract
U Marti, A Wells (2000). The nuclear accumulation of a variant
epidermal growth factor receptor (EGFR) lacking the transmembrane domain
requires co-expression of a full length EGFR. Molecular Cell Biology
Research Communications 3, 8-14.
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to Cell Biology - biochemistry and biophysics
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to Abstract
MA Barbieri, R Roberts, A Gumusboga, H Highfield, C
Alvarez-Dominguez, A Wells, PD Stahl (2000). Signal transduction and membrane
trafficking: activation of MAP kinase and endocytosis by the EGF receptor
requires Rab 5a. Journal of Cell Biology 151, 539-550.
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to Cell Biology - biochemistry and biophysics
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to Abstract
TB Deb, L Su, L Wong, E Bonvini, A Wells, M David, GR
Johnson (2001). EGF receptor kinase-independent signaling by EGF. Journal of
Biological Chemistry 276, 1554-15560.
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to Cell Biology - biochemistry and biophysics
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to Abstract
A Glading, F Uberall, SM Keyse, DA Lauffenburger, A Wells
(2001). Membrane proximal ERK signaling is required for M-calpain activation
downstream of EGF receptor signaling. Journal of Biological Chemistry 276,
23341-23348.
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to Cell Biology - biochemistry and biophysics
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to Abstract
H Xie, T Turner, M-H Wang, RK Singh, GP Siegal, A Wells (1995). Prostate
carcinoma cell, DU-145, invasiveness in vitro is modulated by EGF receptor
signaling. Clinical and Experimental Metastasis 13, 407-419.
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Pathology - tumor progression
Link
to Abstract
T Turner, P Chen, LJ Goodly, A Wells (1996). EGF receptor signaling enhances
in vivo invasiveness of DU-145 human prostate carcinoma cells. Clinical and
Experimental Metastasis 14, 409-418.
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Pathology - tumor progression
Link
to Abstract
WB Parker, SA King, PW Allan, LL Bennett, JA Secrist, JA Montgomery, KS
Gilbert, WR Waud, A Wells, GY Gillespie, EJ Sorscher (1997). In vivo gene
therapyof cancer using E. coli purine nucleoside phosphorylase. Human Gene
Therapy, 8 1637-1644.
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Pathology - tumor progression
Link
to Abstract
RW Hardy, NSMD Wickramasinghe, A Wells (1997). Fatty acids and breast cancer
cell proliferation. Advances in Experimental Medicine and Biology, 422,
57-69.
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Pathology - tumor progression
Link
to Abstract
T Turner, M Van Epps-Fung, J Kassis, A Wells (1997). Molecular inhibition of
PLCg signaling abrogates DU-145 prostate tumor cell invasion. Clinical Cancer
Research 3, 2275-2282.
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Pathology - tumor progression
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to Abstract
T Turner, W Roberts, G R Pettit, A Wells, A Kraft (1998). Treatment of human
prostate cancer with Dolastatin 10, a peptide isolated from a marine shell-less
mollusk. Prostate 34, 175-181.
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Pathology - tumor progression
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to Abstract
H Qin, JD Moellinger, A Wells, LJ Windsor, Y Sun, EN
Benveniste (1998). Transcriptional suppression of matrix metalloproteinase-2
gene expression in human astroglioma cells by TNF-a and
IFN-g. Journal of Immunology 161,
6664-6673.
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Pathology - tumor progression
Link
to Abstract
S Khoshyomn, PL Penar, J Rossi, A Bhushan, A Wells, TR
Tritton, DL Abamson (1999). Inhibition of PLC gamma-1 activation blocks
glioma cell motility and invasion of fetal rat brain aggregates. Neurosurgery
44, 568-577.
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Pathology - tumor progression
Link
to Abstract
JA Secrist, WB Parker, PW Allan, LL Bennett, WR Waud, JW
Truss, AT Fowler, JA Montgomery, SE Ealick, AH Wells, GY Gillespie, VKGadi, EJ
Sorscher (1999). Gene therapy of cancer: activation of nucleoside prodrugs
with E. coli purine nucleoside phosphorylase. Nucleosides and Nucleotides 18,
745-757.
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Pathology - tumor progression
Link
to Abstract
J Kassis, J Moellinger, H Lo, N Greenberg, H Kim, A Wells
(1999). A role for PLCg-mediated signaling in
tumor cell invasion. Clinical Cancer Research 5, 2251-2260.
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Pathology - tumor progression
Link
to Abstract
A Wells (2000). Tumor invasion: role of growth
factor-induced cell motility. Advances in Cancer Research 78,
31-101.
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Pathology - tumor progression
Link
to Abstract
J Kassis, DA Lauffenburger, T Turner, A Wells (2001).
Tumor invasion as dysregulated cell motility. Seminars in Cancer Biology 11,
105-119.
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Pathology - tumor progression
Link
to Abstract
A Wells (2000). The epidermal growth factor receptor ? a
new target in cancer therapy. Signal 1, 4-10.
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Pathology - tumor progression
Link
to Abstract
EJ Manos, M Kim, J Kassis, B Chang, A Wells, DA Jones
(2001). Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase
C-gamma regulated gene negatively associated with prostate tumor invasion.
Oncogene 20, 2781-2790.
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Pathology - tumor progression
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to Abstract
H Shiraha, A Glading, K Gupta, A Wells (1999).
Chemokine transmodulation of EGF Receptor signaling: IP-10 inhibits
motility by decreasing EGF-induced calpain activity. Journal of Cell
Biology 146, 243-253.
Back to
Physiology - wound healing and organ morphogenesis
Link
to Abstract
H Kim, T Turner, J Kassis, A Wells (1999). EGF
receptor signaling in prostate development. Histology and Histopathology
14, 1175-1182.
Back to
Physiology - wound healing and organ morphogenesis
Link
to Abstract
G Maheshwari, G Brown, DA Lauffenburger, A Wells, LG Griffith (2000).
Cell adhesion and motility depend on nanoscale RGD clustering. Journal of
Cell Science 113, 1677-1686.
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Physiology - wound healing and organ morphogenesis
Link
to Abstract
H Shiraha, K Gupta, KA Drabik, A Wells (2000). Preferential loss of
epidermal growth factor receptor results in reduced responsiveness in aging
dermal fibroblasts. Journal of Biological Chemistry 275,
19343-19351.
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Physiology - wound healing and organ morphogenesis
Link
to Abstract
A Wells, MF Ware, FD Allen, DA Lauffenburger (1999). Shapping up for
shipping out: PLC signaling of morphology changes in EGF-stimulated fibroblast
migration. Cell Motility and the Cytoskeleton 44, 227-233.
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Physiology - wound healing and organ morphogenesis
Link
to Abstract
CS Swindel, KT Tran, TD Johnson, P Banerjee, AM Mayes, LG
Griffith, A Wells (2001). Direct activation of the epidermal growth factor
receptor by EGF-like repeats of human tenascin-C. Journal of Cell Biology, in
press.
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Physiology - wound healing and organ morphogenesis
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to Abstract
DA Lauffenburger, A Wells (2001).
Getting a grip: new insights for cell adhesion and traction. Nature Cell Biology
3, E110-112.
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Physiology - wound healing and organ morphogenesis
Link
to Abstract
P Chen, H Xie, A Wells (1996). Mitogenic signaling from the EGF receptor is
attenuated by a phospholipase C-g/protein kinase C feedback mechanism. Molecular
Biology of the Cell 7, 871-881.
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Signaling and metabolic consequences
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to Abstract
M David, L Wong, R Flavell, SA Thompson, A Wells, AC Larner, GR Johnson
(1996).
STAT activation by EGF and amphiregulin: requirement for the EGF
receptor
kinase, but not for tyrosine phosphorylation sites or JAK1. Journal
of Biological
Chemistry 271, 9185-9188.
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Signaling and metabolic consequences
Link
to Abstract
C Reddy, A Wells, DA Lauffenburger (1996). Receptor-mediated effects on
ligand availability influence relative mitogenic potencies of epidermal growth
factor and transforming growth factor a. Journal of Cellular Physiology 166,
512-522.
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Signaling and metabolic consequences
Link
to Abstract
CC Reddy, SK Niyogi, A Wells, HS Wiley, DA Lauffenburger (1996).
Re-engineering epidermal growth factor for enhanced potency. Nature
Biotechnology 14, 1696-1699.
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Signaling and metabolic consequences
Link
to Abstract
CC Reddy, A Wells, DA Lauffenburger (1994). Proliferative response of
fibroblasts expressing internalization-deficient EGF receptors is altered via
differential EGF depletion effects. Biotechnology Progress 10,
377-384.
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Signaling and metabolic consequences
Link
to Abstract
R Hardy, KB Gupta, JM. McDonald, J Williford, A Wells (1995) EGF receptor
carboxy- terminal domains are required for EGF-induced glucose transport in
transgenic 3T3- L1 adipocytes. Endocrinology 136, 431-439.
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Signaling and metabolic consequences
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to Abstract
M Van Epps-Fung, K Gupta, J Williford, RW Hardy, A Wells (1996). Epidermal
growth factor induces glucose storage in transgenic 3T3-L1 adipocytes
overexpressing epidermal growth factor receptors. Diabetes 45,
1619-1625.
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Signaling and metabolic consequences
Link
to Abstract
M Van Epps-Fung, J Williford, A Wells, RW Hardy (1997). Fatty acid-induced
insulin resistance in adipocytes. Endocrinology, 138, 4338-4345.
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Signaling and metabolic consequences
Link
to Abstract
M Van Epps-Fung, K Gupta, R Hardy, A Wells (1997). A role for phospholipase C
activity in GLUT4-mediated glucose transport. Endocrinology, 138,
5170-5175.
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Signaling and metabolic consequences
Link
to Abstract
CC Reddy, A Wells, DA Lauffenburger (1998). Comparative mitogenic potencies
of EGF and TGFa depend on receptor limitation versus ligand-limitation. Medical
and Biological Engineering and Computation 36, 499-507.
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Signaling and metabolic consequences
Link
to Abstract
L Wong, TB Debs, A Wells, SA Thompson, GR Johnson (1999). A
differential requirement for the COOH-terminal region of the EGF receptor in
Amphiregulin and EGF mitogenic signaling. Journal of Biological Chemistry 274,
8900-8909.
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Signaling and metabolic consequences
Link
to Abstract
JM Haugh, A Wells, HS Wiley, DA Lauffenburger (1999). Effect of
epidermal growth factor receptor internalization on regulation of the
phospholipase C-g signaling pathway. Journal of
Biological Chemistry 274, 8958-8965.
Back to
Signaling and metabolic consequences
Link
to Abstract
A Wells (1999). Molecule in Focus: EGF receptor.
International Journal of Biochemistry and Cell Biology
31,637-643.
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Signaling and metabolic consequences
Link
to Abstract
JM Haugh, AC Huang, HS Wiley, A Wells, DA Lauffenburger (1999).
Participation of internalized epidermal growth factor receptors in the
activation of p21ras. Journal of Biological Chemistry 274,
34350-34360.
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Signaling and metabolic consequences
Link
to Abstract
JM Haugh, A Wells, DA Lauffenburger (2000). Mathematical
modeling of epidermal growth factor receptor signaling through the Phospholipase
C pathway: mechanistics insights and predictions for molecular interventions.
Biotechnology and Bioengineering 70, 225-238.
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Signaling and metabolic consequences
Link
to Abstract
RJ Botelho, M Teruel, R Dierckman, R Anderson, A Wells, JD
York, T Meyer, S Grinstein (2000). Localized changes in
phosphatidylinositol-4,5-bisphosphate metabolism during Fcg receptor-mediated
phagocytosis. Journal of Cell Biology 151, 1353-1367.
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Signaling and metabolic consequences
Link
to Abstract
A Wells (2001). The EGF receptor signaling system: a model
for growth factor receptor signaling. Hormone Signaling, in press.
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Signaling and metabolic consequences
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to Abstract