The following grants currently are active in the WellsLab.
The major goals of this project are to determine whether STATs, ERK, uPAR and HGF upregulated downstream of increased EGF receptor signaling promotes prostate tumor progression and how inhibition of of these signaling events prevents prostate tumor invasiveness.
Link to Pathology - tumor progression
Veteran Affairs Research and Development
The major goal of this project is to determine if rear de-adhesion mediated by calpains is important for tumor invasion.
The major goals of this project are to define how regulation of calpain activity serves as a critical switch in the fibroblast to change from the motile phenotype to the contractile phenotype, and how IP-10 modulates this.
Link to Cell Biology - biochemistry and biophysics
Link to Physiology - wound healing & organ morphogenesis
Link to Abstract
The major goals of this project are to determine whether the temporal and spatial organization of adhesion and growth factor receptors affect the signaling and cellular outcomes.
Link to Cell Biology - biochemistry and biophysics
Link to Physiology - wound healing & organ morphogenesis
Link to Abstract
The major goal of this project is to determine whether and by which specific intracellular signaling mechanism LHRH analogues exert a direct inhibitory effect on DU-145 human prostate carcinoma cell growth and tumor development.
The major goal of this project is to determine if intracellular contractility initiated by growth factor receptor or integrin signaling is important for tumor invasion.
The major goal of this supplement is to develop an organotypic liver model of tumor metastasis. Invasive and metastatic prostate cancer cell lines will be seeded into a bioreactor containing normal liver and properties of invasion into the parenchyma, growth, and survival will be assessed.