Wells' Lab - Sources of Support

The following grants currently are active in the Wells Lab.
  1. VA Merit Award (PI: Wells) 10/1/97 - 9/30/06
    Veterans Administration
    "Molecular Regulation of Prostate Cancer Progression"

    The major goals of this project are to determine whether STATs, ERK, uPAR and HGF upregulated downstream of increased EGF receptor signaling promotes prostate tumor progression and how inhibition of of these signaling events prevents prostate tumor invasiveness.

    Link to Pathology - tumor progression
    Veteran Affairs Research and Development

  2. Army Prostate Cancer Grant Program (PI: Wells) 8/1/01 - 7/31/04
    US Army Medical Research Command
    "Cell motility in tumor invasion"

    The major goal of this project is to determine if rear de-adhesion mediated by calpains is important for tumor invasion.

    Link to Abstract

  3. NIGMS (1R01GM/54739) (PI: Wells) 7/1/96 - 6/30/04
    NIGMS
    "Fibroblast cell function in wound healing"

    The major goals of this project are to define how regulation of calpain activity serves as a critical switch in the fibroblast to change from the motile phenotype to the contractile phenotype, and how IP-10 modulates this.

    Link to Cell Biology - biochemistry and biophysics
    Link to Physiology - wound healing & organ morphogenesis
    Link to Abstract

  4. NIGMS (PI: Griffith, MIT) 9/1/99 - 8/31/03
    NIH/NIGMS
    "Bioengineered surfaces for parsing cell signaling"

    The major goals of this project are to determine whether the temporal and spatial organization of adhesion and growth factor receptors affect the signaling and cellular outcomes.

    Link to Cell Biology - biochemistry and biophysics
    Link to Physiology - wound healing & organ morphogenesis
    Link to Abstract

  5. NIH/MBRS (PI: Turner) 5/1/97 - 5/31/05
    NIH/NIGMS
    "Mechanism of prostate cancer inhibition by LHRH analogues"

    The major goal of this project is to determine whether and by which specific intracellular signaling mechanism LHRH analogues exert a direct inhibitory effect on DU-145 human prostate carcinoma cell growth and tumor development.

    Link to Pathology - tumor progression
    Link to Abstract

  6. NCI (CA88865 (PI: Lauffenburger, MIT)) 9/20/01 - 8/31/04
    NIH/NCI
    "Cell motility in prostate tumor invasion"

    The major goal of this project is to determine if intracellular contractility initiated by growth factor receptor or integrin signaling is important for tumor invasion.

    Link to Abstract

  7. NCI (CA88865-02S1 (PI: Lauffenburger, MIT)) 9/20/02 - 8/31/04
    NIH/NCI
    "Cell motility in prostate tumor invasion"

    The major goal of this supplement is to develop an organotypic liver model of tumor metastasis. Invasive and metastatic prostate cancer cell lines will be seeded into a bioreactor containing normal liver and properties of invasion into the parenchyma, growth, and survival will be assessed.

    Link to Abstract