Kenichi (Ken) Tamama, M.D., Ph.D.

709 Scaife
Department of Pathology
University of Pittsburgh
Pittsburgh, PA  15261

412-624-9366

tamamakj@upmc.edu

 

Education

Institution

Degree

Conferred

Field of study

Gunma University School of Medicine, Japan

M.D.

1995

Medicine

Gunma University Graduate School of Medical Sciences, Japan

Ph.D.

2001

Laboratory Medicine

University of Pittsburgh School of Medicine (Residency of Clinical Pathology)

N/A

2005

Laboratory Medicine

 

Honors and Rewards:

2007       ASIP Trainee Travel Award

2006       Paul E. Strandjord Young Investigator Award of Academy of Clinical Laboratory Physicians and Scientists

2006       CP Web Case Winner, Pathology Resident Program, University of Pittsburgh

2005       First place winner in Clinical Research at Retreat of Department of Pathology, University of Pittsburgh

2005       Paul E. Strandjord Young Investigator Award of Academy of Clinical Laboratory Physicians and Scientists

2005       CAP Foundation Scholar Fellowship, College of American Pathologist

2003       CP Web Case Winner, Pathology Resident Program, University of Pittsburgh

2003       Paul E. Strandjord Young Investigator Award of Academy of Clinical Laboratory Physicians and Scientists

2002       Fellowship of Japan-North America Medical Exchange Foundation

2001       Research Grant, Japanese Foundation of Cardiovascular Research

1994       Fellowship of Japan Medical Education Foundation for clinical clerkship in U.K.

 

Invited Lecture:

2006        gBone marrow derived mesenchymal stem cells: Ex vivo expansion and differentiation into vascular cellsh, 

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA (02/24/2006)

 

Editorial Position:

Ad Hoc reviewer   Wound Repair and Regeneration

 

Publications:

Peer-reviewed Articles:

 

Fan VH, Tamama K, Au A, Littrell R, Richardson LB, Wright JW, Wells A, Griffith LG.  Tethered EGF Provides a Survival Advantage to Mesenchymal Stem Cells.  Stem Cells. 2007 Jan; [Epub ahead of print]

 

Tamama K, Fan VH, Griffith LG, Blair HC, and Wells A  Epidermal growth factor receptor ligands as candidates for ex vivo expansion of bone marrow-derived mesenchymal stem cells.  Stem Cells. 2006 Mar;24(3):686-95

 

Tamama K, Tomura H, Sato K, Malchinkhuu E, Damirin A, Kimura T, Kuwabara A,.Murakami M, and Okajima, F   High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component.  Atherosclerosis. 2005 Jan;178(1):19-23.

 

Kimura T, Sato K, Malchinkhuu E, Tomura H, Tamama K, Kuwabara A, Murakami M,  and Okajima F   High-Density Lipoprotein Stimulates Endothelial Cell Migration and Survival Through Sphingosine 1-Phosphate and Its Receptors. Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1283-8.

Tamama K, Sumino H, Ichikawa S, Kanda T, Kotajima N, Fukumura Y, Kurabayashi M, and Murakami M     Hormone replacement therapy causes a decrease in hepatocyte growth factor in hypertensive women.  J Hypertens. 2003 Jun;21(6):1151-1156.

 

Tamama K, Kon J, Sato K, Tomura H, Kuwabara A, Kimura T, Kanda T, Ohta H, Ui M, Kobayashi I, and Okajima F    Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells. Biochemical Journal 2001 Jan 1; 353(Pt 1): 139-146.

 

Arai J, Tamama K, Ishiyama N, Kimura T, Kuwabara A, Kanda T, and Kobayashi I    Contemplation of age-adjusted standard values of lipid profiles in Japan. Journal of Medicine 2000; 31(5-6): 262-70

 

Nishino M, Kimura T, Kanda T, Kotajima N, Yoshida A, Kuwabara A, Tamama K, Fukumura Y, and Kobayashi I   Circulating interleukin-6 significantly correlates to thyroid hormone in acute myocardial infarction but not in chronic heart failure. Journal of Endocrinological Investigation 2000 Sep; 23(8): 509-14.

 

Tamama K, Yamato T, Yoshida M, Sakahira K, Suzuki T, Ishii T, Saito N, Ishiyama N, Kanda T, and Kobayashi I   A case of probable acute interstitial pneumonia with a dramatic response to pulse corticosteroid administration. Journal of Medicine 2000; 31(1-2): 77-89.

 

Kimura T, Watanabe T, Sato K, Kon J, Tomura H, Tamama K, Kuwabara A, Kanda T, Kobayashi I Ohta H, Ui M, and Okajima F    Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the receptors, Edg-1 and Edg-3. Biochemical Journal 2000 May 15; 348 Pt 1:71-6.

 

Kon J, Sato K, Watanabe T, Tomura H, Kuwabara A, Kimura T, Tamama K, Ishizuka T, Murata N, Kanda T, Kobayashi I, Ohta H, Ui M, and Okajima F    Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells. Journal of Biological Chemistry 1999 Aug 20; 274(34):23940-7.

 

Tamama K, Kanda T, Osada M, Nagai R, Suzuki T, and Kobayashi I    Detection of left ventricular enlargement by electrocariography. Journal of Medicine 1998; 29(3-4): 231-6.

 

Review article:

 

Tamama K and Okajima F Sphingosine 1-phosphate signaling in atherosclerosis and vascular biology.  Curr Opin Lipidol 2002 Oct;13(5):489-95.

 

Web case:

 

Tamama K, and Virji MA    A 12 year-old boy presented with substernal chest pain     Case 413 (Jan 2005); http://path.upmc.edu/cases/case413.html

 

Tamama K, Fung M, and Lopez-Plaza I    Severe Transfusion Reaction   Case 355 (July 2003); http://path.upmc.edu/cases/case355.html

 

Tamama K,  Harrison J, and Rao KN   A 38 year-old female with elevated tricyclic antidepressant levels    Case 329 (November 2002); http://path.upmc.edu/cases/case329.html