Molecular & Genomic Pathology - Research

Dr. Chiose's research is focused on understanding the genetic mechanisms of head and neck cancer, particularly in salivary duct carcinoma and human papillomavirus-associated squamous cell carcinomas, and detection of copy number variation of cancer-associated genes by next generation sequencing techniques.

Dr. DeFrances' research is focused on unraveling the contribution of the PI3K pathway to normal liver physiology and hepatocarcinogenesis.

Dr. Locker’s research is funded by the NCI and the NIDDK and focused on the gene control mechanisms that promote liver cancer and cirrhosis.

Dr. Lucas' research laboratory is funded by the NIH and studies the mechanistic links between inflammatory signal transduction (NF-kB activation in particular) and the development of both vascular and neoplastic diseases.

Dr. Luo's lab is funded by the NIH and interested in identifying new tumor suppressor genes, oncogenes and tumor markers in prostate cancer and hepatocellular carcinoma using high throughput and comprehensive analyses.

Dr. Nikiforova's research interests involve genetics of thyroid and brain tumors and developing novel diagnostic laboratory tools based on next-generation sequencing and other genome-wide screenings.

Dr. Nikiforov's research is funded by the NIH and focused on understanding the genetic mechanisms of thyroid cancers and carcinogenesis induced by ionizing radiation.

Dr. Oltvai's research is focused on understanding the system level organization of cell metabolism in prokaryotic and mammalian cells.

Dr. Oury's research is focused on the mechanisms in which the receptor for advanced glycation endproducts promotes recruitment and activation of innate immune cells in asthma and pulmonary fibrosis.

Dr. Roy's research is focused on understanding mechanisms of urothelial carcinogenesis and metastasis using next generation sequencing and microarray technologies and development of biomedical informatics solutions for optimizing clinical laboratory operations and quality management.